Synthesis and discovery of autophagy inducers for A549 and H460 lung cancer cells, novel 1-(2′-hydroxy-3′-aroxypropyl)-3-aryl-1H-pyrazole-5-carbohydr azide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 3860-3864

  Fan, Chuan Dong ^a   Zhao, Bao Xiang ^a   Wei, Fang ^a   Zhang, Gai Hua ^a   Dong, Wen Liang ^b   Miao, Jun Ying ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

A549 cells; Autophagy; H460 cells; Pyrazole carbohydrazide

Indexed keywords

1 [3' (4' CHLOROPHENOXY) 2 HYDROXYPROPYL] 3 (4' CHLOROPHENYL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; PYRAZOLE DERIVATIVE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL DEATH; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LUNG CANCER;

APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; CULTURE MEDIA; DRUG DESIGN; ENDOTHELIUM, VASCULAR; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MODELS, CHEMICAL; PYRAZOLES; TIME FACTORS;

EID: 47349110358     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.058     Document Type: Article

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