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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5374-5377

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents

(6) Lv, Peng Cheng a Li, Dong Dong a Li, Qing Shan a Lu, Xiang a Xiao, Zhu Ping a Zhu, Hai Liang a

a NANJING UNIVERSITY (China)

Author keywords

Anticancer; EGFR TK; Inhibitors; Molecular docking; Thiazolyl pyrazoline derivatives

Indexed keywords

4 (4 CHLOROPHENYL) 2 [3 (3,4 DIMETHYLPHENYL) 5 4 TOLYL 4,5 DIHYDRO 1H PYRAZOL 1 YL]THIAZOLE; ANTINEOPLASTIC AGENT; ERLOTINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; THIAZOLYLPYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZOLES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 80051931734 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.07.010 Document Type: Article

Times cited : (142)

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