Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 314-319

  Lv, Peng Cheng ^a   Zhou, Chang Fang ^a   Chen, Jin ^a   Liu, Peng Gang ^a   Wang, Kai Rui ^a   Mao, Wen Jun ^a   Li, Huan Qiu ^a   Yang, Ying ^a   Xiong, Jing ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Anticancer; EGFR; HER 2; Inhibitors; SAR; Thiazolidinone derivatives

Indexed keywords

2 (2 CYCLOBUTYLIDENEHYDRAZINYL)THIAZOL 4(5H) ONE; 2 (2 CYCLOHEPTYLIDENEHYDRAZINYL)THIAZOL 4(5H) ONE; 2 (2 CYCLOHEXYLIDENEHYDRAZINYL)THIAZOL 4(5H) ONE; 2 (2 CYCLOOCTYLIDENEHYDRAZINYL)THIAZOL 4(5H) ONE; 2 (2 CYCLOPENTYLIDENEHYDRAZINYL)THIAZOL 4(5H) ONE; 2 [2 (3 BROMOBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (3 CHLOROBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (3 FLUOROBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (3 HYDROXYBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (3 METHOXYBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (3 METHYLBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (3 NITROBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (3,5 DIBROMO 2 HYDROXYBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (3,5 DICHLORO 2 HYDROXYBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (4 BROMOBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (4 CHLOROBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (4 FLUOROBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (4 HYDROXYBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (4 METHOXYBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (4 METHYLBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (4 NITROBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (5 BROMO 2 HYDROXYBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (5 CHLORO 2 HYDROXYBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; 2 [2 (5 FLUORO 2 HYDROXYBENZYLIDENE)HYDRAZINYL]THIAZOL 4(5H) ONE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; SIMULATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; NEOPLASMS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 72049095834     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.051     Document Type: Article

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