Astaxanthin protects against MPP+-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis

BMC Neuroscience

Volumn 13, Issue 1, 2012, Pages

  Ye, Qinyong ^a   Huang, Bixia ^a   Zhang, Xiaodong ^a   Zhu, Yuangui ^a   Chen, Xiaochun ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Astaxanthin; HO 1; MPP+; NOX2; Parkinson's disease; PC12 cells

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ASTAXANTHIN; HEME OXYGENASE 1; HEMIN; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL ISOLATION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; IMMUNOFLUORESCENCE MICROSCOPY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

1-METHYL-4-PHENYLPYRIDINIUM; ANTIOXIDANTS; CATECHOLAMINES; CELL SURVIVAL; DOPAMINE AGONISTS; DRUG INTERACTIONS; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HEMIN; IMIDAZOLINES; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PC12 CELLS; REACTIVE OXYGEN SPECIES; XANTHOPHYLLS;

EID: 84871590215     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-13-156     Document Type: Article

References (40)

1. Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443:787-795. 10.1038/nature05292, 17051205.
2. Olanow CW. Oxidation reactions in Parkinson's disease. Neurology 1990, 40:suppl 32-suppl 37. discussion37-39.
3. Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, Albanese A, Nussbaum R, González-Maldonado R, Deller T, Salvi S, Cortelli P, Gilks WP, Latchman DS, Harvey RJ, Dallapiccola B, Auburger G, Wood NW. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004, 304:1158-1160. 10.1126/science.1096284, 15087508.
4. Lohr JB, Browning JA. Free radical involvement in neuropsychiatric illnesses. Psychopharmacol Bull 1995, 31:159-165.
5. Stadtman ER. Role of oxidant species in aging. Curr Med Chem 2004, 11:1105-1112. 10.2174/0929867043365341, 15134509.
6. Seegal RF, Brosch K, Bush B, Ritz M, Shain W. Effects of Aroclor 1254 on dopamine and norepinephrine concentrations in pheochromocytoma (PC-12)cells. Neurotoxicology 1989, 10:757-764.
7. Li XL, Cheng WD, Li J, Guo XL, Guo CJ, Meng XH, Sun SG, Wang LX. Protective effect of estrogen on apoptosis in a cell culturemodel of Parkinson's disease. Clin Invest Med 2008, 31:E258-E264.
8. Chiba K, Trevor A, Castagnoli N. Metabolism of the neurotoxic tertiary amine,MPTP, by brainmonoamine oxidase. Biochem Biophys Res Commun 1984, 120:574-578. 10.1016/0006-291X(84)91293-2, 6428396.
9. Wang XJ, Zhang S, Yan ZQ, Zhao YX, Zhou HX, Wang Y, Lu GQ, Zhang JD. Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK. Free Radic Biol Med 2011, 50:1094-1106. 10.1016/j.freeradbiomed.2011.01.032, 21295135.
10. Sorce S, Krause K-H. NOX Enzymes in the Central Nervous System: From Signaling to Disease. Antioxid Redox signaling 2009, 11:2481-2504.
11. Le WD, Xie WJ, Appel SH. Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury. J Neurosci Res 1999, 56:652-658. 10.1002/(SICI)1097-4547(19990615)56:6<652::AID-JNR11>3.0.CO;2-5, 10374820.
12. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997, 37:517-554. 10.1146/annurev.pharmtox.37.1.517, 9131263.
13. Bae JW, Kim MJ, Jang CG, Lee SY. Protective effects of heme oxygenase-1 against MPP(+)-induced cytotoxicity in PC-12 cells. Neurol Sci 2010, 31:307-313. 10.1007/s10072-010-0216-6, 20127499.
14. Hwang YP, Jeong HG. The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress. FEBS Lett 2008, 582:2655-2662. 10.1016/j.febslet.2008.06.045, 18593583.
15. Cheng SE, Lee IT, Lin CC, Kou YR, Yang CM. Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src/NADPH oxidase/MAPK/Nrf2 signaling pathway. Free Radic Biol Med 2010, 48:1410-1422. 10.1016/j.freeradbiomed.2010.02.026, 20188821.
16. Minelli A, Conte C, Grottelli S, Bellezza I, Emiliani C, Bolaños JP. Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling. J Neurochem 2009, 111:956-966. 10.1111/j.1471-4159.2009.06376.x, 19735445.
17. Dae-Hee L, Yong J, Lee1, Ki Han K. Neuroprotective effects of Astaxanthin in Oxygen-Glucose deprivation in SH-SY5Y cells and global cerebral ischemia in rat. J Clin Biochem Nutr 2010, 47:121-129. 10.3164/jcbn.10-29, 2935152, 20838567.
18. Liu X, Shibata T, Hisaka S, Osawa T. Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism. Brain Res 2009, 1254:18-27.
19. Chang CH, Chen CY, Chiou JY, Peng RY, Peng CH. Astaxanthine secured apoptotic death of PC12 cells induced by beta-amyloid peptide 25-35: its molecular action targets. J Med Food 2010, 13:548-556. 10.1089/jmf.2009.1291, 20521980.
20. Naguib YM. Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem 2000, 48:1150-1154. 10.1021/jf991106k, 10775364.
21. Holland PM, Abramson RD, Watson R, Gelfand DH. Detection of specific polymerase chain reaction product by utilizing the 5′--3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc Natl Acad Sci USA 1991, 88:7276-7280. 10.1073/pnas.88.16.7276, 52277, 1871133.
22. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(2-Delta Delta C(T)) Method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
23. Wang H-Q, Sun X-B, Yu-Xia X, Zhao H, Zhu Q-Y, Zhu C-Q. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain research 2010, 1360:159-167.
24. Harrigan TJ, Abdullaev IF, Jourd'heuil D, Mongin AA. Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels:the role of NADPH oxidases. J Neurochem 2008, 106:2449-2462. 10.1111/j.1471-4159.2008.05553.x, 2574595, 18624925.
25. Zawada WM, Banninger GP, Thornton J, Marriott B, Cantu D, Rachubinski AL, Das M, Griffin WS, Jones SM. Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade. J Neuroinflammation 2011, 8:129. 10.1186/1742-2094-8-129, 3198931, 21975039.
26. Taillé C, El-Benna J, Lanone S, Dang MC, Ogier-Denis E, Aubier M, Boczkowski J. Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability. J Biol Chem 2004, 279:28681-28688. 10.1074/jbc.M310661200, 15123630.
27. Datla SR, Dusting GJ, Mori TA, Taylor CJ, Croft KD, Fan J. Induction of Heme Oxygenase-1 In Vivo Suppresses NADPH Oxidase-Derived Oxidative Stress. Hypertension 2007, 50:636-642. 10.1161/HYPERTENSIONAHA.107.092296, 17679649.
28. Worou ME, Belmokhtar K, Bonnet P, Vourc'h P, Machet MC, Khamis G, Eder V. Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling. Cardiovasc Res 2011, 91:320-329. 10.1093/cvr/cvr072, 21406596.
29. Li MH, Cha YN, Surh YJ. Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related factor 2 in PC12 cells. Free Radic Biol Med 2006, 41:1079-1091. 10.1016/j.freeradbiomed.2006.06.010, 16962933.
30. Samoylenko A, Dimova EY, Horbach T, Teplyuk N, Immenschuh S, Kietzmann T. Opposite expression of the antioxidant heme oxygenase-1 in primary cells and tumor cells: regulation by interaction of USF-2 and Fra-1. Antioxid. Redox Signal 2008, 10:1163-1174. 10.1089/ars.2007.1968, 18331200.
31. Burton NC, Kensler TW, Guilarte TR. In vivo modulation of the parkinsonian phenotype by Nrf2. Neurotoxicology 2006, 27:1094-1100. 10.1016/j.neuro.2006.07.019, 16959318.
32. Biswas S, Chida AS, Rahman I. Redox modification of protein-thiols:emerging roles in cell signaling. Biochem Pharmacol 2006, 71:551-564. 10.1016/j.bcp.2005.10.044, 16337153.
33. Li JM, Gall NP, Grieve DJ, Chen M, Shah AM. Activation of NADPH oxidase during progression of cardiac hypertrophy to failure. Hypertension 2002, 40:477-484. 10.1161/01.HYP.0000032031.30374.32, 12364350.
34. Di Monte D, Sandy MS, Ekström G, Smith MT. Comparative studies on the mechanisms of paraquat and 1-methyl-4-phenylpyridine (MPP+) cytotoxicity. Biochem Biophys Res Commun 1986, 137:303-309. 10.1016/0006-291X(86)91210-6, 3487318.
35. Liu X, Osawa T. Astaxanthin protects neuronal cells against oxidative damage and is a potent candidate for brain food. Forum Nutr 2009, 61:129-135.
36. Tripathi DN, Jena GB. Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: Role of Nrf2, p53, p38 and phase-II enzymes. Mutation Research 2010, 696:69-80. 10.1016/j.mrgentox.2009.12.014, 20038455.
37. Curek GD, Cort A, Yucel G, Demir N, Ozturk S, Elpek GO, Savas B, Aslan M. Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion. Toxicology 2010, 267:147-153. 10.1016/j.tox.2009.11.003, 19900500.
38. Chan KC, Mong MC, Yin MC. Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells. J Food Sci 2009, 74:H225-H231. 10.1111/j.1750-3841.2009.01274.x, 19895474.
39. Shen H, Kuo CC, Chou J, Delvolve A, Jackson SN, Post J, Woods AS, Hoffer BJ, Wang Y, Harvey BK. Astaxanthin reduces ischemic brain injury in adult rats. FASEB J 2009, 23:1958-1968. 10.1096/fj.08-123281, 2698661, 19218497.
40. Park JS, Chyun JH, Kim YK, Line LL, Chew BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond) 2010, 7:2-10.