Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells

Journal of Food Science

Volumn 74, Issue 7, 2009, Pages

  Chan, Kung Chi ^a   Mong, Mei Chin ^b   Yin, Mei Chin ^c  

^a PROVIDENCE UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Anti inflammatory; Antioxidative; Astaxanthin; Canthaxanthin; Membrane stability; Neurodegeneration; Neuroprotection; PC12 cells

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ASTAXANTHIN; CANTHAXANTHIN; CASPASE 3; CYTOKINE; HYDROGEN PEROXIDE; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENT; XANTHOPHYLL;

ANIMAL; ARTICLE; CELL MEMBRANE; CELL STRAIN; CELL SURVIVAL; DEGENERATIVE DISEASE; DNA FRAGMENTATION; DOSE RESPONSE; DRUG EFFECT; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL; OXIDATIVE STRESS; PHYSIOLOGY; RAT; SECRETION;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CANTHAXANTHIN; CASPASE 3; CELL MEMBRANE; CELL SURVIVAL; CYTOKINES; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NERVE GROWTH FACTOR; NEURODEGENERATIVE DISEASES; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; RATS; SODIUM-POTASSIUM-EXCHANGING ATPASE; XANTHOPHYLLS;

EID: 69749118947     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2009.01274.x     Document Type: Article

References (31)

1. Andersen LP, Holck S, Kupcinskas L, Kiudelis G, Jonaitis L, Janciauskas D, Permin H, Wadström T. 2007. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. FEMS Immunol Med Microbiol 50 : 244 248.
2. Beal MF. 2003. Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann N Y Acad Sci 991 : 120 131.
3. Carpenter KL, Van Der Veen C, Hird R, Dennis IF, Ding T, Mitchinson MJ. 1997. The carotenoids beta-carotene, canthaxanthin and zeaxanthin inhibit macrophage-mediated LDL oxidation. FEBS Lett 401 : 262 266.
4. Chapman S, Kadar T, Gilat E. 2006. Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain. Neurotoxicology 27 : 277 283.
5. Coyle JT, Puttfarcken P. 1993. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262 : 689 695.
6. Ferger B, Leng A, Mura A, Hengerer B, Feldon J. 2004. Genetic ablation of tumor necrosis factor-alpha (TNF-alpha) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum. J Neurochem 89 : 822 833.
7. Fu W, Luo H, Parthasarathy S, Mattson MP. 1998. Catecholamines potentiate amyloid β-peptide neurotoxicity: involvement of oxidative stress, mitochondrial dysfunction, and perturbed calcium homeostasis. Neurobiol Dis 5 : 229 243.
8. Greene LA, Tischler AS. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73 : 2424 2428.
9. Hald A, Lotharius J. 2005. Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Exp Neurol 193 : 279 290.
10. Hébert G, Arsaut J, Dantzer R, Demotes-Mainard J. 2003. Time-course of the expression of inflammatory cytokines and matrix metalloproteinases in the striatum and mesencephalon of mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a dopaminergic neurotoxin. Neurosci Lett 349 : 191 195.
11. Hussein G, Sankawa U, Goto H, Matsumoto K, Watanabe H. 2006. Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod 69 : 443 449.
12. Ikeda Y, Tsuji S, Satoh A, Ishikura M, Shirasawa T, Shimizu T. 2008. Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cell. J Neurochem 107 : 1730 1740.
13. Jiang B, Liu JH, Bao YM, An LJ. 2004. Catalpol inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Toxicon 43 : 53 9.
14. Kang JO, Kim SJ, Kim H. 2001. Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl4-treated rats. Methods Find Exp Clin Pharmacol 23 : 79 84.
15. Lee SJ, Bai SK, Lee KS, Namkoong S, Na HJ, Ha KS, Han JA, Yim SV, Chang K, Kwon YG, Lee SK, Kim YM. 2003. Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation. Mol Cells 16 : 97 105.
16. Lipman T, Tabakman R, Lazarovici P. 2006. Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the nerve growth factor-differentiated model of pheochromocytoma PC12 cell. Eur J Pharmacol 549 : 50 7.
17. Liu X, Shibata T, Hisaka S, Osawa T. 2009. Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism. Brain Res 1254 : 18 27.
18. Lowry OH, Rosebrough NJ, Farr AL. 1951. Protein determination with the Folin phenol reagent. J Biol Chem 193 : 265 275.
19. Matsura T, Kai M, Fujii Y, Ito H, Yamada K. 1999. Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation. Free Radic Res 30 : 73 83.
20. Mecocci P, MacGarvey U, Beal MF. 1994. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36 : 747 751.
21. +-ATPase. J Membr Biol 156 : 63 71.
22. Nagatsu T, Mogi M, Ichinose H, Togari A. 2000. Changes in cytokines and neurotrophins in Parkinson's disease. J Neural Trans 60 : 277 279.
23. Pashkow FJ, Watumull DG, Campbell CL. 2008. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Am J Cardiol 101 : 58 68.
24. Pettmann B, Henderson CE. 1998. Neuronal cell death. Neuron 20 : 633 647.
25. Rausch DM, Dickens G, Doll S, Fujita K, Koizumi S, Rudkin BB, Tocco M, Eiden LE, Guroff G. 1989. Differentiation of PC12 cells with v-src: comparison with nerve growth factor. J Neurosci Res 24 : 49 58. (Pubitemid 19262385)
26. Richardson JR, Caudle WM, Wang M, Dean ED, Pennell KD, Miller GW. 2006. Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease. FASEB J 20 : 1695 1697.
27. Singh U, Devaraj S, Jialal I. 2005. Vitamin E, oxidative stress, and inflammation. Ann Rev Nutr 25 : 151 174.
28. 2+-ATPase activities in rat brain synaptosomes. J Physiol Pharmacol 55 : 457 465.
29. Tukov FF, Rimoldi JM, Matthews JC. 2004. Characterization of the role of glutathione in repin-induced mitochondrial dysfunction, oxidative stress and dopaminergic neurotoxicity in rat pheochromocytoma (PC12) cell. Neurotoxicology 25 : 989 999.
30. +-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. J Cell Sci 116 : 2099 2110.
31. Whitton PS. 2007. Inflammation as a causative factor in the aetiology of Parkinson's disease. Br J Pharmacol 150 : 963 976.