Astaxanthine secured apoptotic death of PC12 cells induced by β-amyloid peptide 25-35: Its molecular action targets

Journal of Medicinal Food

Volumn 13, Issue 3, 2010, Pages 548-556

  Chang, Chi Huang ^a   Chen, Chung Yin ^b   Chiou, Jueen Ya ^a   Peng, Robert Y ^a,c   Peng, Chiung Huei ^a  

^a HUNGKUANG UNIVERSITY   (Taiwan)

^b Division of Cardiology   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bax; calcium homeostasis; caspase; interleukin 1 ; nuclear factor B; p38 mitogen activated protein kinase; reactive oxygen species; tumor necrosis factor

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; ASTAXANTHIN; BIOLOGICAL MARKER; CALCIUM ION; CASPASE 3; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL SURVIVAL; PC12 CELLS; PEPTIDE FRAGMENTS; RATS; XANTHOPHYLLS;

CRUSTACEA;

EID: 77953756431     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2009.1291     Document Type: Article

References (36)

1. Chyau CC, ed.: The Super Antioxidant-Astaxanthine and Its Bioactivity. Yuan-Qi Chaii Book Co., Taichung, Taiwan, 2007.
2. Guerin M, Huntley ME, Olaizola M: Haematococcus astaxanthine: applications for human health and nutrition. Trends Biotechnol 2003;21:210-216.
3. Liu X, Osawa T: Cis-astaxanthine and especially 9-cis astaxanthine exhibits a higher antioxidant activity in vitro compared to the all-trans isomer. Biochem Biophys Res Commun 2007;357: 187-193.
4. Kontush A, Berndt C, Weber W, Akopyan V, Arlt S, Schippling S, Beisiegel U: Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma. Free Radic Biol Med 2001;30: 119-128.
5. Koudinov AR, Berezov TT: Alzheimers amyloid-beta (Ab) is an essential synaptic protein, not neurotoxic junk. Acta Neurobiol Exp 2004;64:71-79.
6. Kowall N, McKee A, Yankner B, Beal M: In vivo neurotoxicity of beta-amyloid [b (1-40)] and the b (25-35) fragment. Neurobiol Aging 1992;13:537-542.
7. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG: Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003;300:486-489.
8. Alzheimers Disease Education & Referral Center, National Institute on Aging: Beta-Amyloid and Its Damaging Effects on Neurons. www.nia.nih.gov= Alzheimers=Publications= ADProgress2005-2006=Part2=beta-amyloid.htm.htm (accessed February 16, 2010).
9. Holscher C, Gengler S, Gault VA, Harriott P, Mallot HA: Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning. Eur J Pharmacol 2007;561:85-90.
10. Meng H, Li C, Feng L, Cheng B, Wu F, Wang X, Li Z, Liu S: Effects of ginkgolide B on 6-OHDA-induced apoptosis and calcium over load in cultured PC12. Int J Dev Neurosci 2007;25: 509-514.
11. Rosenstock TR, Carvalho AC, Jurkiewicz A, Frussa-Filho R, Smaili SS: Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid. J Neurochem 2004;88:1220-1228.
12. Lee SY, Ha TY, Son DJ, Kim SR, Hong JT: Effect of sesaminol glucosides on b-amyloid-induced PC-12 cell death through antioxidant mechanisms. Neurosci Res 2005;52:330-341.
13. Ishige K, Schubert D, Sagara Y: Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 2001;30:433-446.
14. Nunomura A, Moreira PI, Lee HG, Zhu X, Castellani RJ, Smith MA, Perry G: Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neurol Disord Drug Targets 2007;6:411-423.
15. Salinska E, Danysz W, Lazarewicz JW: The role of excitotoxicity in neurodegeneration. Folia Neuropathol 2005;43: 322-339.
16. Hynd MR, Scott HL, Dodd PR: Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimers disease. Neurochem Int 2004;45:583-595.
17. Etcheberrigaray R, Ito E, Kim CS, Alkon DL: Soluble betaamyloid induction of Alzheimers phenotype for human fibroblast K channels. Science 1994;264:276-279.
18. 2+ exchanger in excitotoxicity. Cell 2005;120:275-285.
19. Song YS, Park HJ, Kim SY, Lee SH, Yoo HS, Lee HS, Lee MK, Oh KW, Kang SK, Lee SE, Hong JT: Protective role of Bcl-2 on beta-amyloid-induced cell death of differentiated PC12 cells: reduction of NF-kappaB and p38 MAP kinase activation. Neurosci Res 2004;49:69-80.
20. Shen Y, He P, Zhong Z, Mcallister C, Lindholm K: Distinct destructive signal pathways of neuronal death in Alzheimers disease. Trends Mol Med 2006;12:574-579.
21. Eckert A, Hauptmann S, Scherping I, Virginie RV, Müller-Spahn FF, Götz J, Mü ller WE: Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegen Dis 2008;5:157-159.
22. Yan SD, Chen X, Fu J, Chen M, Zhu HJ, Rober A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM: RAGE and amyloid-b peptide neurotoxicity in Alzheimers disease. Nature 1996;383:685-691.
23. Guan ZZ, Miao H, Tian JY, Unger C, Nordberg A, Zhang X: Suppressed expression of nicotinic acetylcholine receptors by nanomolar beta-amyloid peptides in PC12 cells. J Neural Transm 2001;108:1417-1433. (Pubitemid 34020446)
24. Lambert MP, Barlow AK, Chromy BA, Edwards C, Fred R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL: Diffusible nonfirillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 1998;95: 6448-6453.
25. Abe K, Hisatomi R, Misawa M: Amyloid b-peptide specially promotes phosphorylation and nuclear translocation of the extracellular signal-regulated kinase in cultured rat cortical astrocytes. J Pharmacol Sci 2003;93:272-278. (Pubitemid 37521348)
26. Dineley KT, Westerman M, Bui D, Bell K, Ashe KH, Sweatt JD: b-Amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptor: in vitro and in vivo mechanisms related to Alzheimers disease. J Neurosci 2001;21:4125-4133.
27. Mattson MP: Pathways towards and away from Alzheimers disease. Nature 2004;430:631-639.
28. Nassif M, Hoppe J, Santin K, Prozza R, Zamin LL, Simão F, Horn AP, Salbego C: b-Amyloid peptides toxicity in organotypic hippocampal slice culture involves Akt=PKB, GSK-3b, and PTEN. Neurochem Int 2007;50:229-235.
29. 2+ homeostasis and cell death. J Neurosci 1995;15:6239-6249.
30. Vaisid T, Kosower NS, Elkind E, Barnoy S: Amyloid-b peptide toxicity in differentiated PC12 cells: calpain-calpastatin, caspase, and membrane damage. J Neurosci Res 2008;86:2314-2325.
31. Jang JH, Surh YJ: b-Amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NFkappaB signaling pathway. Free Radic Biol Med 2005;38:1604-1613.
32. Malek S, Chen Y, Huxford T, Ghosh G: IkBb, but not IkBa functions as a classical cytoplasmic inhibitor of NFkB nuclear localization sequences in resting cells. J Biol Chem 2001;276: 45225-45235.
33. Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G: X-ray crystal structure of an IkBb-NFkB p65 homodimer complex. J Biol Chem 2003;278:23094-23100.
34. Ikonomovic MD, Mizukami K, Warde D, Sheffield R, Hamilton R, Wenthold RJ, Armstrong DM: Distribution of glutamate receptor subunit NMDAR1 in the hippocampus of normal elderly and patients with Alzheimers disease. Exp Neurol 1999;160: 194-204.
35. Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW: DNA repair, genome stability, and aging. Cell 2005;120: 497-512.
36. Lan L, Nakajima S, Oohata Y, Takao M, Okano S, Masutani M, Wilson SH, Yasui A: In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proc Natl Acad Sci USA 2004;101:13738-13743.