Structural and functional characterization of the kindlin-1 pleckstrin homology domain

Journal of Biological Chemistry

Volumn 287, Issue 52, 2012, Pages 43246-43261

  Yates, Luke A ^a   Lumb, Craig N ^b   Brahme, Nina N ^c   Zalyte, Ruta ^a   Bird, Louise E ^a,d   De Colibus, Luigi ^a   Owens, Raymond J ^a,d   Calderwood, David A ^c   Sansom, Mark S P ^b   Gilbert, Robert J C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d RUTHERFORD APPLETON LABORATORY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASMIC TAIL; FUNCTIONAL CHARACTERIZATION; INOSITOL PHOSPHATE; INTEGRIN ACTIVATION; INTEGRINS; MOLECULAR DOCKING; MOLECULAR DYNAMICS SIMULATIONS; MONOPHOSPHATES; PHOSPHATE BINDING; PHOSPHOINOSITIDE BINDING; PHYSIOLOGICAL LIGANDS; PLECKSTRIN HOMOLOGY DOMAINS; POTENTIAL LIGAND; PROTEIN FAMILY; SALT BRIDGES; SITE DIRECTED MUTAGENESIS; STRUCTURAL COMPARISON; SUBDOMAIN; X RAY CRYSTAL STRUCTURES;

LIGANDS; MOLECULAR DYNAMICS; PHOSPHORYLATION; PLASMONS; SUGARS; SURFACE PLASMON RESONANCE;

ALCOHOLS;

BINDING PROTEIN; INOSITOL PHOSPHATE; INTEGRIN; KINDLIN 1 PROTEIN; KINDLIN 2 PROTEIN; KINDLIN 3 PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PLECKSTRIN; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SEQUENCE ALIGNMENT; SIMULATION; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; MICE; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS; PHOSPHATES; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871578671     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.422089     Document Type: Article

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