Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation

Journal of Biological Chemistry

Volumn 286, Issue 50, 2011, Pages 43334-43342

  Liu, Jianmin ^a   Fukuda, Koichi ^a   Xu, Zhen ^a   Ma, Yan Qing ^a   Hirbawi, Jamila ^a   Mao, Xian ^b   Wu, Chuanyue ^c   Plow, Edward F ^a   Qin, Jun ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Cleveland Center for Structural and Membrane Biology   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; HEAD GROUPS; INTEGRIN ACTIVATION; INTEGRIN RECEPTORS; INTEGRINS; KEY REGULATORS; NMR STRUCTURES; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; PHOSPHOINOSITIDE BINDING; PHOSPHOINOSITIDES; PLECKSTRIN HOMOLOGY DOMAINS; STRUCTURAL BASIS; WILD TYPES;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPIDS; SUGARS;

CHEMICAL ACTIVATION;

ALPHA2BBETA3 INTEGRIN; INOSITOL 1,3,4,5 TETRAKISPHOSPHATE; INTEGRIN; KINDLIN 2; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PLECKSTRIN; TALIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; MEMBRANE BINDING; MUTANT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; WILD TYPE;

MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; NEOPLASM PROTEINS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLINOSITOLS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 83355174039     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.295352     Document Type: Article

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