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European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 1-9

Microwave-assisted synthesis of pyrimido[4,5-b][1,6]naphthyridin-4(3H)-ones with potential antitumor activity

(6) Insuasty, Braulio a Becerra, Diana a Quiroga, Jairo a Abonia, Rodrigo a Nogueras, Manuel b Cobo, Justo b

a UNIVERSIDAD DEL VALLE (Colombia)

b UNIVERSITY OF JAÉN (Spain)

Author keywords

Antitumor activity; Catalyst free conditions; Microwave irradiation; p Chloranil; Pyrimido 4,5 b 1,6 naphthyridine

Indexed keywords

7 ETHYL 9 (4 METHOXYBENZYLIDENE) 5 (4 METHOXYPHENYL) 2 (METHYLTHIO) 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B][1,6]NAPHTHYRIDIN 4(3H,5H,10H)ONE; 7 ETHYL 9 (4 METHYLBENZYLIDENE) 2 (METHYLTHIO) 5 (4 TOLYL) 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B][1,6]NAPHTHYRIDIN; 7 METHYL 2 (METHYLTHIO) 9 (4 NITROBENZYLIDENE) 5 (4 NITROPHENYL) 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B][1,6]NAPHTHYRIDIN 4(3H,5H,10H)ONE; 9 (4 BROMOBENZYLIDENE) 5 (4 BROMOPHENYL) 7 METHYL 2 (METHYLTHIO) 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B][1,6]NAPHTHYRIDIN 4(3H,5H,10H)ONE; 9 (4 CHLOROBENZYLIDENE) 5 (4 CHLOROPHENYL) 7 METHYL 2 (METHYLTHIO) 6,7,8,9 TETRAHYDROPYRIMIDOL[4,5 B]NAPTHYRIDIN 4(3H,5H,10H)ONE; ANTINEOPLASTIC AGENT; NAPHTHYRIDINE DERIVATIVE; PYRIMIDO[4,5 B][1,6]NAPHTHYRIDIN 4(3H) ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROWAVE IRRADIATION; OXIDATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROWAVES; MOLECULAR STRUCTURE; NAPHTHYRIDINES; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871558347 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2012.11.037 Document Type: Article

Times cited : (47)

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