Synthesis of bioactive polyheterocyclic ring systems as 5α-reductase inhibitors

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 4838-4844

  Abdel Hafez, Naglaa A ^a   Farghaly, Thoraya A ^b   Al Omar, Mohamed A ^c   Abdalla, Mohamed M ^d  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d MAPCO Pharmaceuticals Ltd   (Egypt)

Author keywords

5 Reductase inhibitors; Hydrazonoyl halides; Piperidone; Polyheterocycles

Indexed keywords

2 (3,4 DIMETHOXYPHENYLMETHYLENE) THIAZOLO[3',2':1,2]PYRIMIDO[4,5 B][1,6]NAPHTHYRIDINE 3,5 DIONE; 3 ACETYL 1 PHENYL 5 (4 METHYLPHENYL) 9 (4 METHYLPHENYLMETHYLENE) 7 ETHYL 5H 6,7,8,9 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRIDO[4,3 D]PYRIMIDINE; 3 ACETYL 1 PHENYL 6 (4 METHYLPHENYL) 10 (4 METHYLPHENYLMETHYLENE) 8 ETHYL 7,9 DIHYDRO[1,2,4]TRIAZOLO[4',3':1,2]PYRIMIDO[4,5 B][1,6] NAPHTHYRIDINE 5 ONE; 3 ACETYL 7 ETHYL 1 (4 CHLOROPHENYL) 5 (4 METHYLPHENYL) 9 (4 METHYLPHENYLMETHYLENE) 5H 6,7,8,9 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRIDO[4,3 D] PYRIMIDINE; 3 ETHOXYCARBOMYL 7 ETHYL 1 (4 CHLOROPHENYL) 9 (4 METHYLPHENYLMETHYLENE) 5H 6,7,8,9 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRIDO[4,3 D]PYRIMIDINE; 3 ETHOXYCARBONYL 1 PHENYL 6 (4 METHYLPHENYL) 10 (4 METHYLPHENYL METHYLENE) 8 ETHYL 7,9 DIHYDRO[1,2,4]TRIAZOLO[4',3':1,2]PYRIMIDO[4,5 B][1,6] NAPHTHYRIDINE 5 ONE; 3 ETHOXYCARBONYL 7 ETHYL 1 (4 METHYLPHENYL) 5 (4 METHYLPHENYL) 9 (4 METHYLPHENYLMETHYLENE) 5H 6,7,8,9 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRIDO[4,3 D] PYRIMIDINE; 3 ETHOXYCARBONYL 7 ETHYL 1 PHENYL 5 (4 METHYLPHENYL) 9 (4 METHYLPHENYLMETHYLENE) 5H 6,7,8,9 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRIDO[4,3 D]PYRIMIDINE; 3 PHENYLCARBAMOYL 1 (4 CHLOROPHENYL) 6 (4 METHYLPHENYL) 10 (4 METHYLPHENYL METHYLENE) 8 ETHYL 7,9 DIHYDRO[1,2,4]TRIAZOLO[4',3':1,2]PYRIMIDO[4,5 B][1,6] NAPHTHYRIDINE 5 ONE; 6 ETHYL 8 (4 METHYLPHENYLMETHYLENE) 2 (METHYLTHIO) 4 (4 METHYPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE; 6 ETHYL 8 (4 METHYLPHENYLMETHYLENE) 4 (4 METHYLPHENYL) 3,4,5,6,7,8 HEXAHYDROPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 7 ETHYL 3 PHENYLCARBAMOYL 1 (4 CHLOROPHENYL) 5 (4 METHYLPHENYL) 9 (4 METHYLPHENYLMETHYLENE) 5H 6,7,8,9 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRIDO[4,3 D] PYRIMIDINE; 7 ETHYL 3 PHENYLCARBAMOYL 1 (4 METHYLPHENYL) 5 (4 METHYLPHENYL) 9 (4 METHYLPHENYLMETHYLENE) 5H 6,7,8,9 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRIDO[4,3 D] PYRIMIDINE; 7 ETHYL 3 PHENYLCARBAMOYL 1 PHENYL 5 (4 METHYLPHENYL) 9 (4 METHYLPHENYLMETHYLENE) 5H 6,7,8,9 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRIDO[4,3 D] PYRIMIDINE; 7 ETHYL 9 (4 METHYLPHENYLMETHYLENE) 5 (4 METHYLPHENYL) 2 HYDRAZINO 2,3,6,7,8,9 HEXAHYDRO PYRIMIDO[4,5 B][1,6]NAPHTHYRIDINE (4H) ONE; 7 ETHYL 9 (4 METHYLPHENYLMETHYLENE) 5 (4 METHYLPHENYL) 2 THIOXO 2,3,6,7,8,9 HEXAHYDRO PYRIMIDO[4,5 B][1,6]NAPHTHYRIDINE (4H) ONE; ANASTROZOLE; BROMOACETIC ACID; HYDRALAZINE; STEROID 5ALPHA REDUCTASE INHIBITOR; THIAZOLO[3',2':1,2]PYRIMIDO[4,5 B][1,6]NAPHTHYRIDINE 3,5 DIONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; LD 50; MALE; NONHUMAN; RAT; SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 5-ALPHA REDUCTASE INHIBITORS; ANIMALS; CRYSTALLOGRAPHY, X-RAY; HETEROCYCLIC COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, INFRARED;

EID: 77957843092     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.07.053     Document Type: Article

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