Efficient microwave-assisted synthesis and antitumor activity of novel 4,4′-methylenebis[2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols]

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2436-2440

  Insuasty, Braulio ^a   García, Angélica ^a   Quiroga, Jairo ^a   Abonia, Rodrigo ^a   Ortiz, Alejandro ^a   Nogueras, Manuel ^b   Cobo, Justo ^b  

^a UNIVERSIDAD DEL VALLE   (Colombia)

^b UNIVERSITY OF JAÉN   (Spain)

Author keywords

3,3 Methylenebis(6 hydroxy 3,1 phenylene) bis(1 arylprop 2 en 1 ones); Antitumor activity; Bis diarylpyrazolines; Hydrazine hydrate; Microwave irradiation

Indexed keywords

3,3' [METHYLENEBIS(6 HYDROXY 3,1 PHENYLENE)]BIS(1 ARYL PROP 2 EN 1 ONE); 4,4' METHYLENEBIS 2 (3 (1,3 BENZODIOXOL 5 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL)PHENOL; 4,4' METHYLENEBIS 2 (3 (4 BROMOPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL)PHENOL; 4,4' METHYLENEBIS 2 (3 (4 CHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL)PHENOL; 4,4' METHYLENEBIS 2 (3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL)PHENOL; 4,4' METHYLENEBIS 2 (3 (4 METHYLPHENYL) 4,5 DIHYDRO 1H PYRAZOL5 YL)PHENOL; 4,4' METHYLENEBIS[2 (3 ARYL 4,5 DIHYDRO 1H PYRAZOL 5 YL)PHENOLS; ACETIC ACID; HYDRAZINE; METHYLENEBIS 2 (3 (4 BROMOPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL) 4,1 PHENYLENE DIACETATE; METHYLENEBIS 2 (3 (4 CHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL) 4,1 PHENYLENE DIACETATE; METHYLENEBIS 2 (3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL) 4,1 PHENYLENE DIACETATE; METHYLENEBIS 2 (3 (4 METHYLPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL) 4,1 PHENYLENE DIACETATE; METHYLENEBIS 2 (3 ARYL 4,5 DIHYDRO 1H PYRAZOL 5 YL) 4,1 PHENYLENE DIACETATE; METHYLENEBIS 2 [3 (1,3 BENZODIOXOL 5 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 4,1 PHENYLENE DIACETATE; PYRAZOLINE DERIVATIVE; SALICYLALDEHYDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CARBON NUCLEAR MAGNETIC RESONANCE; COLON CANCER; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; KIDNEY CANCER; LEUKEMIA CELL; LUNG NON SMALL CELL CANCER; MELANOMA; MICROWAVE IRRADIATION; OVARY CANCER; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROWAVES; MOLECULAR STRUCTURE; PHENOLS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955637701     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.028     Document Type: Article

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