Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Gupta, Karishma ^a   Thakur, Vijay S ^a,c   Bhaskaran, Natarajan ^a,c   Nawab, Akbar ^a,c,d   Babcook, Melissa A ^a,b,c   Jackson, Mark W ^a   Gupta, Sanjay ^a,b,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 8; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; FAS ASSOCIATED DEATH DOMAIN PROTEIN; GUANOSINE TRIPHOSPHATE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE H3; POLYPHENOL; PROTEIN BAD; PROTEIN BAX; PROTEIN C JUN; PROTEIN P21; PROTEIN P53; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR; TRICHOSTATIN A;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CHROMATIN; CONTROLLED STUDY; DOSE RESPONSE; DOWNSTREAM PROCESSING; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MECHANICS; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; TEA; UPREGULATION;

ACETYLATION; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CAMPTOTHECIN; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DRUG SCREENING ASSAYS, ANTITUMOR; GENE KNOCKDOWN TECHNIQUES; HISTONE DEACETYLASES; HISTONES; HUMANS; MALE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PHOSPHOSERINE; POLYPHENOLS; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION; TEA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84871438152     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052572     Document Type: Article

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