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Volumn 26, Issue 5, 2012, Pages 910-917

Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia

Author keywords

acute myeloid leukemia; in vivo imaging; Nutlin 3; p53; valproic acid

Indexed keywords

CD34 ANTIGEN; NUTLIN 3; PROTEIN P53; VALPROIC ACID;

EID: 84860750821     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.315     Document Type: Article
Times cited : (73)

References (38)
  • 1
    • 79952086942 scopus 로고    scopus 로고
    • Therapeutic advances in acute myeloid leukemia
    • Burnett A, Wetzler M, Lowenberg B. Therapeutic advances in acute myeloid leukemia. J Clin Oncol 2011; 29: 487-494.
    • (2011) J Clin Oncol , vol.29 , pp. 487-494
    • Burnett, A.1    Wetzler, M.2    Lowenberg, B.3
  • 2
    • 33751267902 scopus 로고    scopus 로고
    • Acute myeloid leukaemia
    • Estey E, Dohner H. Acute myeloid leukaemia. Lancet 2006; 368: 1894-1907.
    • (2006) Lancet , vol.368 , pp. 1894-1907
    • Estey, E.1    Dohner, H.2
  • 3
    • 55049114781 scopus 로고    scopus 로고
    • Current and emerging strategies for the management of acute myeloid leukemia in the elderly
    • Laubach J, Rao AV. Current and emerging strategies for the management of acute myeloid leukemia in the elderly. Oncologist 2008; 13: 1097-1108.
    • (2008) Oncologist , vol.13 , pp. 1097-1108
    • Laubach, J.1    Rao, A.V.2
  • 5
    • 0242624636 scopus 로고    scopus 로고
    • Epigenetic targets in hematopoietic malignancies
    • Claus R, Lubbert M. Epigenetic targets in hematopoietic malignancies. Oncogene 2003; 22: 6489-6496.
    • (2003) Oncogene , vol.22 , pp. 6489-6496
    • Claus, R.1    Lubbert, M.2
  • 6
  • 7
    • 27644568226 scopus 로고    scopus 로고
    • MDM2 antagonists induce p53-dependent apoptosis in AML: Implications for leukemia therapy
    • Kojima K, Konopleva M, Samudio IJ, Shikami M, Cabreira-Hansen M, McQueen T et al. MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood 2005; 106: 3150-3159.
    • (2005) Blood , vol.106 , pp. 3150-3159
    • Kojima, K.1    Konopleva, M.2    Samudio, I.J.3    Shikami, M.4    Cabreira-Hansen, M.5    McQueen, T.6
  • 8
    • 39049142019 scopus 로고    scopus 로고
    • Oral valproic acid for epilepsy-long-term experience in therapy and side effects
    • Gerstner T, Bell N, Konig S. Oral valproic acid for epilepsy-long-term experience in therapy and side effects. Expert Opin Pharmacother 2008; 9: 285-292.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 285-292
    • Gerstner, T.1    Bell, N.2    Konig, S.3
  • 9
    • 37249071337 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer treatment: A review of the clinical toxicity and the modulation of gene expression in cancer cell
    • Bruserud O, Stapnes C, Ersvaer E, Gjertsen BT, Ryningen A. Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cell. Curr Pharm Biotechnol 2007; 8: 388-400.
    • (2007) Curr Pharm Biotechnol , vol.8 , pp. 388-400
    • Bruserud, O.1    Stapnes, C.2    Ersvaer, E.3    Gjertsen, B.T.4    Ryningen, A.5
  • 10
    • 63349103376 scopus 로고    scopus 로고
    • A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated with the combination of valproic acid, theophylline and all-trans retinoic acid
    • Ryningen A, Stapnes C, Lassalle P, Corbascio M, Gjertsen BT, Bruserud O. A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated with the combination of valproic acid, theophylline and all-trans retinoic acid. Leuk Res 2009; 33: 779-787.
    • (2009) Leuk Res , vol.33 , pp. 779-787
    • Ryningen, A.1    Stapnes, C.2    Lassalle, P.3    Corbascio, M.4    Gjertsen, B.T.5    Bruserud, O.6
  • 11
    • 58849158362 scopus 로고    scopus 로고
    • Valproic acid and all-trans retinoic acid: Meta-analysis of a palliative treatment regimen in AML and MDS patients
    • Bellos F, Mahlknecht U. Valproic acid and all-trans retinoic acid: meta-analysis of a palliative treatment regimen in AML and MDS patients. Onkologie 2008; 31: 629-633.
    • (2008) Onkologie , vol.31 , pp. 629-633
    • Bellos, F.1    Mahlknecht, U.2
  • 12
    • 79751528245 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia
    • Quintas-Cardama A, Santos FP, Garcia-Manero G. Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia. Leukemia 2011; 25: 226-235.
    • (2011) Leukemia , vol.25 , pp. 226-235
    • Quintas-Cardama, A.1    Santos, F.P.2    Garcia-Manero, G.3
  • 13
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 2007; 26: 5541-5552.
    • (2007) Oncogene , vol.26 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 14
    • 52449116207 scopus 로고    scopus 로고
    • CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer
    • Chrisanthar R, Knappskog S, Lokkevik E, Anker G, Ostenstad B, Lundgren S et al. CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer. PLoS One 2008; 3: e3062.
    • (2008) PLoS One , vol.3
    • Chrisanthar, R.1    Knappskog, S.2    Lokkevik, E.3    Anker, G.4    Ostenstad, B.5    Lundgren, S.6
  • 15
    • 34249780126 scopus 로고    scopus 로고
    • Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells
    • Wergeland L, Sjoholt G, Haaland I, Hovland R, Bruserud O, Gjertsen BT. Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells. Mol Cancer 2007; 6: 33.
    • (2007) Mol Cancer , vol.6 , pp. 33
    • Wergeland, L.1    Sjoholt, G.2    Haaland, I.3    Hovland, R.4    Bruserud, O.5    Gjertsen, B.T.6
  • 16
    • 75649113906 scopus 로고    scopus 로고
    • Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
    • Bredholt T, Dimba EA, Hagland HR, Wergeland L, Skavland J, Fossan KO et al. Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Mol Cancer 2009; 8: 101.
    • (2009) Mol Cancer , vol.8 , pp. 101
    • Bredholt, T.1    Dimba, E.A.2    Hagland, H.R.3    Wergeland, L.4    Skavland, J.5    Fossan, K.O.6
  • 18
    • 76549129820 scopus 로고    scopus 로고
    • Drug combination studies and their synergy quantification using the Chou-Talalay method
    • Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 2010; 70: 440-446.
    • (2010) Cancer Res , vol.70 , pp. 440-446
    • Chou, T.C.1
  • 20
    • 0036201888 scopus 로고    scopus 로고
    • Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and-independent apoptotic signaling pathways
    • Kawagoe R, Kawagoe H, Sano K. Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and-independent apoptotic signaling pathways. Leuk Res 2002; 26: 495-502.
    • (2002) Leuk Res , vol.26 , pp. 495-502
    • Kawagoe, R.1    Kawagoe, H.2    Sano, K.3
  • 21
    • 34547663854 scopus 로고    scopus 로고
    • Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia
    • Bug G, Schwarz K, Schoch C, Kampfmann M, Henschler R, Hoelzer D et al. Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia. Haematologica 2007; 92: 542-545.
    • (2007) Haematologica , vol.92 , pp. 542-545
    • Bug, G.1    Schwarz, K.2    Schoch, C.3    Kampfmann, M.4    Henschler, R.5    Hoelzer, D.6
  • 22
    • 34547239148 scopus 로고    scopus 로고
    • In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: Time-domain autofluorescence decoupling, fluorophore quantification, and localization
    • McCormack E, Micklem DR, Pindard LE, Silden E, Gallant P, Belenkov A et al. In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: time-domain autofluorescence decoupling, fluorophore quantification, and localization. Mol Imaging 2007; 6: 193-204.
    • (2007) Mol Imaging , vol.6 , pp. 193-204
    • McCormack, E.1    Micklem, D.R.2    Pindard, L.E.3    Silden, E.4    Gallant, P.5    Belenkov, A.6
  • 23
    • 44849091255 scopus 로고    scopus 로고
    • Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
    • Kumamoto K, Spillare EA, Fujita K, Horikawa I, Yamashita T, Appella E et al. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res 2008; 68: 3193-3203.
    • (2008) Cancer Res , vol.68 , pp. 3193-3203
    • Kumamoto, K.1    Spillare, E.A.2    Fujita, K.3    Horikawa, I.4    Yamashita, T.5    Appella, E.6
  • 24
    • 0037184969 scopus 로고    scopus 로고
    • Acetylation of p53 inhibits its ubiquitination by Mdm2
    • Li M, Luo J, Brooks CL, Gu W. Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem 2002; 277: 50607-50611.
    • (2002) J Biol Chem , vol.277 , pp. 50607-50611
    • Li, M.1    Luo, J.2    Brooks, C.L.3    Gu, W.4
  • 25
    • 84856522761 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression
    • e-pub ahead of print 3 August 2010 doi:10.007/s10637-010-9510-7
    • Palani C, Beck J, Sonnemann J. Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression. Invest New Drugs 2010; e-pub ahead of print 3 August 2010; doi:10.007/s10637-010-9510-7.
    • (2010) Invest New Drugs
    • Palani, C.1    Beck, J.2    Sonnemann, J.3
  • 27
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death?
    • Baehrecke EH. Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 2005; 6: 505-510.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 28
    • 42349085572 scopus 로고    scopus 로고
    • MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2
    • Gu L, Zhu N, Findley HW, Zhou M. MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2. Leukemia 2008; 22: 730-739.
    • (2008) Leukemia , vol.22 , pp. 730-739
    • Gu, L.1    Zhu, N.2    Findley, H.W.3    Zhou, M.4
  • 29
    • 0037112901 scopus 로고    scopus 로고
    • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
    • Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E et al. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. Embo J 2002; 21: 6236-6245.
    • (2002) Embo J , vol.21 , pp. 6236-6245
    • Ito, A.1    Kawaguchi, Y.2    Lai, C.H.3    Kovacs, J.J.4    Higashimoto, Y.5    Appella, E.6
  • 30
    • 38949199337 scopus 로고    scopus 로고
    • HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function
    • Lau LM, Nugent JK, Zhao X, Irwin MS. HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function. Oncogene 2008; 27: 997-1003.
    • (2008) Oncogene , vol.27 , pp. 997-1003
    • Lau, L.M.1    Nugent, J.K.2    Zhao, X.3    Irwin, M.S.4
  • 31
    • 34249796391 scopus 로고    scopus 로고
    • Valproic acid inhibits adhesion of vincristine-and cisplatin-resistant neuroblastoma tumour cells to endothelium
    • Blaheta RA, Michaelis M, Natsheh I, Hasenberg C, Weich E, Relja B et al. Valproic acid inhibits adhesion of vincristine-and cisplatin-resistant neuroblastoma tumour cells to endothelium. Br J Cancer 2007; 96: 1699-1706.
    • (2007) Br J Cancer , vol.96 , pp. 1699-1706
    • Blaheta, R.A.1    Michaelis, M.2    Natsheh, I.3    Hasenberg, C.4    Weich, E.5    Relja, B.6
  • 32
    • 77955907917 scopus 로고    scopus 로고
    • Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia
    • Long J, Parkin B, Ouillette P, Bixby D, Shedden K, Erba H et al. Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia. Blood 2010; 116: 71-80.
    • (2010) Blood , vol.116 , pp. 71-80
    • Long, J.1    Parkin, B.2    Ouillette, P.3    Bixby, D.4    Shedden, K.5    Erba, H.6
  • 33
    • 33845256980 scopus 로고    scopus 로고
    • MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin
    • Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J Biol Chem 2006; 281: 33030-33035.
    • (2006) J Biol Chem , vol.281 , pp. 33030-33035
    • Hu, B.1    Gilkes, D.M.2    Farooqi, B.3    Sebti, S.M.4    Chen, J.5
  • 34
  • 35
    • 18644384085 scopus 로고    scopus 로고
    • Animal models of acute myelogenous leukaemia-development, application and future perspectives
    • McCormack E, Bruserud O, Gjertsen BT. Animal models of acute myelogenous leukaemia-development, application and future perspectives. Leukemia 2005; 19: 687-706.
    • (2005) Leukemia , vol.19 , pp. 687-706
    • McCormack, E.1    Bruserud, O.2    Gjertsen, B.T.3
  • 36
    • 31544436322 scopus 로고    scopus 로고
    • AML engraftment in the NOD/SCID assay reflects the outcome of AML: Implications for our understanding of the heterogeneity of AML
    • Pearce DJ, Taussig D, Zibara K, Smith LL, Ridler CM, Preudhomme C et al. AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood 2006; 107: 1166-1173.
    • (2006) Blood , vol.107 , pp. 1166-1173
    • Pearce, D.J.1    Taussig, D.2    Zibara, K.3    Smith, L.L.4    Ridler, C.M.5    Preudhomme, C.6
  • 37
    • 51649109186 scopus 로고    scopus 로고
    • Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains
    • Agliano A, Martin-Padura I, Mancuso P, Marighetti P, Rabascio C, Pruneri G et al. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 2008; 123: 2222-2227.
    • (2008) Int J Cancer , vol.123 , pp. 2222-2227
    • Agliano, A.1    Martin-Padura, I.2    Mancuso, P.3    Marighetti, P.4    Rabascio, C.5    Pruneri, G.6
  • 38
    • 35148842829 scopus 로고    scopus 로고
    • P53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo: New hope for treating aggressive viral lymphomas
    • Sarek G, Ojala PM. p53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo: new hope for treating aggressive viral lymphomas. Cell Cycle 2007; 6: 2205-2209.
    • (2007) Cell Cycle , vol.6 , pp. 2205-2209
    • Sarek, G.1    Ojala, P.M.2


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