In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug

International Journal of Cancer

Volumn 67, Issue 3, 1996, Pages 386-392

  Blagosklonny, Mikhail V ^a   El Deiry, Wafik S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; MITOMYCIN C; PROTEIN P53; VINCRISTINE;

ADENOVIRUS; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG DNA BINDING; DRUG POTENTIATION; DRUG RESISTANCE; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; GENE MUTATION; GENE THERAPY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOVIRIDAE; ADENOVIRUS INFECTIONS, HUMAN; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DRUG RESISTANCE, MULTIPLE; EVALUATION STUDIES; GENES, P53; GLIOBLASTOMA; HUMANS; LUNG NEOPLASMS; NEOPLASMS; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029832231     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960729)67:3<386::AID-IJC13>3.0.CO;2-6     Document Type: Article

References (34)

1. BLAGOSKLONNY, M.V., TORETSKY, J. and NECKERS, L.M., Geldanamycin selectively destabilizes and conformationally alters mutated p53. Oncogene, 11, 933-939 (1995).
2. CAJOT, J.F., ANDERSON, M.J., LEHMAN, T.A., SHAPIRO, H., BRIGGS, A.A. and STANBRIDGE, E.J., Growth suppression mediated by transfection of p53 in Hut292DM human lung cancer cells expressing endogenous wild-type p53 protein. Cancer Res., 52, 6956-6960 (1992).
3. CHANG, M.W., BARR, E., SELTZER, J., JIANG, Y.-Q., NABEL, G.J., NABEL, E.G., PARMACEK, M.S. and LEIDEN, J.M., Cytostatic gene therapy for vascular proliferative disorders with constitutively active form of the retinoblastoma gene product. Science, 267, 518-522 (1995).
4. CHEN, S.H., SHINE, H.D., GOODMAN, J.C., GROSSMAN, R.G. and WOO, S.L., Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. nat. Acad. Sci. (Wash.), 91, 3054-3057 (1994).
5. CROSS, S.M., SANCHEZ, C.A., MORGAN, C.A., SCHIMKE, M.K., RAMEL, S., IDZERDA, R.L., RASKIND, W.H. and REID, B.J., A p53-dependent mouse spindle checkpoint. Science, 267, 1353-1356 (1995).
6. DARZYNKIEWICZ, Z., Li, X. and GONG, J., Assays of cell viability: discrimination of cells dying by apoptosis. Methods Cell Biol., 41, 15-38 (1994).
7. DONEHOWER, L.A., HARVEY, M., SLAGLE, B.L., MCARTHUR, M.L., MONTGOMERY, C.A.J., BUTEL, J.S. and BRADLEY, A., Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature (Lond.), 356, 215-221 (1992).
8. 1 arrest and apoptosis. Cancer Res., 54, 1169-1174 (1994).
9. EL-DEIRY, W.S., TOKINO, T., VELCULESCU, V.E., LEVY, D.B., PARSONS, R., TRENT, J.M., LIN, D., MERCER, W.E., KINZLER, K.W. and VOGELSTEIN, B., WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-325 (1993).
10. FAN, S., EL-DEIRY, W.S., BAE, I., FREEMAN, J., JONDLE, D., BHATIA, K., FORNACE, JR., A.J., MAGRATH, J., KOHN, K.W. and O'CONNOR, P.M., p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res., 54, 5824-5830 (1994).
11. FUJIWARA, T., GRIMM, E.A., MUKHOPADHYAY, T., ZHANG, W.W., OWEN-SCHAUB, L.B. and ROTH, J.A., Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res., 54, 2287-2291 (1994).
12. GREENBLATT, M.S., BENNETT, W.P., HOLLSTEIN, M. and HARRIS, C.C., Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54, 4855-4878 (1994).
13. GUDAS, J.M., NGUYEN, H., KLEIN, R.C., KATAYOSE, D., SETH, P. and COWAN, K.H., Differential expression of multiple MDM2 messenger RNAs and proteins in normal and tumorigenic breast epithelial cells. Clin. Cancer Res., 1, 71-80 (1995).
14. HARTWELL, L.H. and KASTAN, M.B., Cell cycle control and cancer. Science, 266, 1821-1828 (1994).
15. JIN, X., NGUYEN, D., ZHANG, W.-W., KYRITSIS, A.P. and ROTH, J.A., Cell cycle arrest and inhibition of tumor cell proliferation by the p16/INK4 gene mediated by an adenovirus vector. Cancer Res., 55, 3250-3253 (1995).
16. KATAYOSE, D., GUDAS, J., NGUYEN, H., SRIVASTAVA, S., COWAN, K.H. and SETH, P., Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells. Clin. Cancer Res., 1, 889-897 (1995).
17. KNOWLES, M.R. and 13 OTHERS, A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N. Engl. J. Med., 333, 823-831 (1995).
18. KOZARSKY, K.F. and WILSON, J.M., Gene therapy: adenovirus vectors. Curr. Opin. Genet. Dev., 3, 499-503 (1993).
19. LAI, G.-M., CHEN, Y.-N., MICKLEY, L.A., FOJO, A.T. and BATES, S.E., P-glycoprotein expression and schedule dependence of Adriamycin cytotoxicity in human colon carcinoma cell lines. Int. J. Cancer, 49, 696-703 (1991).
20. LIU, T.J., EL-NAGGAR, A.K., MCDONNELL, T.J., STECK, K.D., WANG, M., TAYLOR, D.L. and CLAYMAN, G.L., Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res., 55, 3117-3122 (1995).
21. MALKIN, D., LI, F.P., STRONG, L.C., FRAUMENI, J.J.F., NELSON, C.E., KIM, D.H., KASSEL, J., GRYKA, M.A., BISCHOFF, F.Z., TAINSKY, M.A. and FRIEND, S.H., Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science, 250, 1233-1238 (1990).
22. MERCER, W.E., SHIELDS, M.T., AMIN, M., SAUVE, G.J., APPELLA, E., ROMANO, J.W. and ULLRICH, S.J., Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses wild-type p53. Proc. nat. Acad. Sci. (Wash.), 87, 6166-6170 (1990).
23. MITANI, K., WAKAMIYA, M. and CASKEY, C.T., Long-term expression of retroviral-transduced adenosine deaminase in human primitive hematopoietic progenitors. Hum. Gene Ther., 4, 9-16 (1993).
24. NECKERS, L., WHITESELL, L., ROSOLEN, A. and GESELOWITZ, D.A., Antisense inhibition of oncogene expression. Crit. Rev. Oncology, 3, 175-231 (1992).
25. O'MALLEY, B.W. JR., CHEN, S.H., SCHWARTZ, M.R. and WOO, S.L., Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model. Cancer Res., 55, 1080-1085 (1995).
26. ROSENBERG, S.A. and 11 OTHERS, The development of gene therapy for the treatment of cancer. Ann Surg., 218, 455-463 (1993).
27. SMYTHE, W.R., HWANG, H.C., ELSHAMI, A.A., AMIN, K.M., ALBELDA, S.M. and KAISER, L.R., Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy. J. Thoracic Cardiovasc. Surg., 109, 626-631 (1995).
28. VAN MEIR, E.G., POLVERINI, P.J., CHAZIN, V.R., HUANG, H.-J.S., DE TRIBOLET, N. and CAVENEE, W.K., Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nature (Genet.), 8, 171-176 (1994).
29. VELCULESCU, V.E. and EL-DEIRY, W.S., Biological and clinical importance of the p53 tumor suppressor gene. Clin. Chem. (1996) in press.
30. WILLS, K.N. and 12 OTHERS, Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Hum Gene Ther., 5, 1079-1088 (1994).
31. WU, J.K., CANO, W.G., MEYLAERTS, S.A., QI, P., VRIONIS, F. and CHERINGTON, V., Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery, 35, 1094-1102 (1994).
32. YANG, C., CIRIELLI, C., CAPOGROSSI, M.C. and PASSANITI, A., Adeno-virus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of prostatic tumor cells. Cancer Res., 55, 4210-4213 (1995).
33. ZHANG, W.W. and ROTH, J.A., Anti-oncogene and tumor suppressor gene therapy - examples from a lung cancer animal model. In Vivo, 8, 755-769 (1994).
34. ZHANG, Y., YU, p., XIA, W. and HUNG, M.-C, HER-2/neu-targeting cancer therapy via adenovirus-mediated E1A delivery in an animal model Oncogene, 10, 1947-1954 (1995).