Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency

Experimental Diabetes Research

Volumn 2012, Issue , 2012, Pages

  Kose, Hiroyuki ^a,b   Yamada, Takahisa ^c   Matsumoto, Kozo ^b,d  

^a INTERNATIONAL CHRISTIAN UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

^d KYOTO SANGYO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DIABETES MELLITUS; DISEASE MODEL; DISEASE SEVERITY; GENE; LEPTIN DEFICIENCY; NIDD2 OF GENE; NONHUMAN; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RAT; ANIMAL; BLOOD; BODY WEIGHT; CONGENIC STRAIN; CROSS BREEDING; FISCHER 344 RAT; GENETIC PREDISPOSITION; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TRANSGENIC RAT;

BIOLOGICAL MARKER; CHOLESTEROL; FATTY ACID; INSULIN; LEPTIN RECEPTOR; TRIACYLGLYCEROL;

ADIPOSITY; ANIMALS; ANIMALS, CONGENIC; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; CROSSES, GENETIC; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FATTY ACIDS, NONESTERIFIED; GENETIC PREDISPOSITION TO DISEASE; INSULIN; MUTATION; OBESITY; PHENOTYPE; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED F344; RATS, INBRED OLETF; RATS, TRANSGENIC; RECEPTORS, LEPTIN; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

MLCS; MLOWN;

EID: 84871432061     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2012/858121     Document Type: Article

References (32)

1. World Health Organization (WHO), Strategy on Diet, Physical Activity, and Health 2000
2. Zimmet P., Alberti K. G. M. M., Shaw J., Global and societal implications of the diabetes epidemic. Nature 2001 414 6865 782 787 2-s2.0-0035856920 10.1038/414782a (Pubitemid 34000780)
3. Orahilly S., Human genetics illuminates the paths to metabolic disease. Nature 2009 462 7271 307 314 2-s2.0-70450193472 10.1038/nature08532
4. Altshuler D., Daly M. J., Lander E. S., Genetic mapping in human disease. Science 2008 322 5903 881 888 2-s2.0-55449120805 10.1126/science.1156409
5. Saxena R., Voight B. F., Lyssenko V., Burtt N. P., De Bakker P. I. W., Chen H., Roix J. J., Kathiresan S., Hirschhorn J. N., Daly M. J., Hughes T. E., Groop L., Altshuler D., Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007 316 5829 1331 1336 2-s2.0-34249888775 10.1126/science.1142358 (Pubitemid 46871653)
6. Zeggini E., Weedon M. N., Lindgren C. M., Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007 316 5829 1336 1341 10.1126/science.1142364 (Pubitemid 46871654)
7. Scott L. J., Mohlke K. L., Bonnycastle L. L., Willer C. J., Li Y., Duren W. L., Erdos M. R., Stringham H. M., Chines P. S., Jackson A. U., Prokunina-Olsson L., Ding C. J., Swift A. J., Narisu, Hu T., Pruim R., Xiao R., Li X. Y., Conneely K. N., Riebow N. L., Sprau A. G., Tong M., White P. P., Hetrick K. N., Barnhart M. W., Bark C. W., Goldstein J. L., Watkins L., Xiang F., Saramies J., Buchanan T. A., Watanabe R. M., Valle T. T., Kinnunen L., Abecasis G. R., Pugh E. W., Doheny K. F., Bergman R. N., Tuomilehto J., Collins F. S., Boehnke M., A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants. Science 2007 316 5829 1341 1345 2-s2.0-34249885875 10.1126/science.1142382 (Pubitemid 46871655)
8. Aitman T. J., Critser J. K., Cuppen E., Progress and prospects in rat genetics: a community view. Nature Genetics 2008 40 5 516 522 10.1038/ng.147 (Pubitemid 351601225)
9. Chen D., Wang M. W., Development and application of rodent models for type 2 diabetes. Diabetes, Obesity and Metabolism 2005 7 4 307 317 2-s2.0-21444439423 10.1111/j.1463-1326.2004.00392.x (Pubitemid 40916572)
10. Islam M. S., Loots D. T., Experimental rodent models of type 2 diabetes: a review. Methods and Findings in Experimental and Clinical Pharmacology 2009 31 4 249 261 2-s2.0-69849084908 10.1358/mf.2009.31.4.1373958
11. Kawano K., Hirashima T., Mori S., Kurosumi M., Saitoh Y., A new rat strain with non-insulin-dependent diabetes mellitus, 'OLETF'. Rat News Letter 1991 25 24 26
12. Watanabe T. K., Okuno S., Oga K., Mizoguchi-Miyakita A., Tsuji A., Yamasaki Y., Hishigaki H., Kanemoto N., Takagi T., Takahashi E. I., Irie Y., Nakamura Y., Tanigami A., Genetic dissection of 'OLETF,' a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF. Genomics 1999 58 3 233 239 2-s2.0-0033564275 10.1006/geno.1999.5789 (Pubitemid 29300305)
13. Moralejo D. H., Wei S., Wei K., Weksler-Zangen S., Koike G., Jacob H. J., Hirashima T., Kawano K., Sugiura K., Sasaki Y., Ogino T., Yamada T., Matsumoto K., Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long-Evans Tokushima Fatty rat. Proceedings of the Association of American Physicians 1998 110 6 545 558 2-s2.0-18344405434 (Pubitemid 28516130)
14. Kose H., Moralejo D. H., Ogino T., Mizuno A., Yamada T., Matsumoto K., Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Mammalian Genome 2002 13 10 558 562 2-s2.0-0036800834 10.1007/s00335-002-2199-y (Pubitemid 35217507)
15. Fukumura T., Kose H., Takeda C., Kurita Y., Ochiai K., Yamada T., Matsumoto K., Genetic interaction between hyperglycemic QTLs is manifested under a high calorie diet in OLETF-derived congenic rats. Experimental Animals 2011 60 2 125 132 2-s2.0-79955404291 10.1538/expanim.60.125
16. Akhi M., Kose H., Matsumoto K., Fine mapping of the hyperglycemic and obesity QTL by congenic strains suggests multiple loci on rat chromosome 14. Journal of Medical Investigation 2005 52 1-2 109 113 2-s2.0-15544366464 10.2152/jmi.52.109
17. Kose H., Bando Y., Izumi K., Yamada T., Matsumoto K., Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat. Mammalian Genome 2007 18 8 609 615 2-s2.0-34848911901 10.1007/s00335-007-9031-7 (Pubitemid 47497921)
18. Phillips M. S., Liu Q., Hammond H. A., Dugan V., Hey P. J., Caskey C. J., Hess J. F., Leptin receptor missense mutation in the fatty Zucker rat. Nature Genetics 1996 13 1 18 19 2-s2.0-0030137757
19. Markel P., Shu P., Ebeling C., Carlson G. A., Nagle D. L., Smutko J. S., Moore K. J., Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nature Genetics 1997 17 3 280 284 2-s2.0-0030659604 10.1038/ng1197-280 (Pubitemid 27475989)
20. Iida M., Murakami T., Ishida K., Mizuno A., Kuwajima M., Shima K., Substitution at codon 269 (glutamine → proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochemical and Biophysical Research Communications 1996 224 2 597 604 2-s2.0-0030590070 10.1006/bbrc.1996.1070 (Pubitemid 26268230)
21. Ogino T., Wei S., Wei K., Moralejo D. H., Kose H., Mizuno A., Shima K., Sasaki Y., Yamada T., Matsumoto K., Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF. Genomics 2000 70 1 19 25 2-s2.0-0034672505 10.1006/geno.2000.6349
22. Zucker L. M., Zucker T. F., Fatty, a new mutation in the rat. Journal of Heredity 1961 52 6 275 278 2-s2.0-77957216320
23. Clee S. M., Nadler S. T., Attie A. D., Genetic and genomic studies of the BTBR ob/ob mouse model of type 2 diabetes. American Journal of Therapeutics 2005 12 6 491 498 2-s2.0-28044456923 10.1097/01.mjt.0000178781.89789.25 (Pubitemid 41689749)
24. Stoehr J. P., Nadler S. T., Schueler K. L., Rabaglia M. E., Yandell B. S., Metz S. A., Attie A. D., Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci. Diabetes 2000 49 11 1946 1954 2-s2.0-0033761365
25. Peterson R. G., Shaw W. N., Neel M.-A., Little L. A., Eichberg J., Zucker diabetic fatty rat as a model for non-insulin-dependent diabetes mellitus. ILAR News 1990 32 3 16 19
26. fa associated with variability in insulin production and susceptibility to NIDDM. Genomics 1997 41 3 332 344 2-s2.0-0031128599 10.1006/geno.1997.4672 (Pubitemid 27194784)
27. Scherneck S., Nestler M., Vogel H., Blüher M., Block M. D., Diaz M. B., Herzig S., Schulz N., Teichert M., Tischer S., Al-Hasani H., Kluge R., Schürmann A., Joost H. G., Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. PLoS Genetics 2009 5 7 2-s2.0-68249127301 10.1371/journal.pgen.1000541 e1000541
28. Bhatnagar S., Oler A. T., Rabaglia M. E., Positional cloning of a type 2 diabetes quantitative trait locus, tomosyn-2, a negative regulator of insulin secretion. PLoS Genetics 2011 7 10 e1002323
29. Dokmanovic-Chouinard M., Chung W. K., Chevre J. C., Watson E., Yonan J., Wiegand B., Bromberg Y., Wakae N., Wright C. V., Overton J., Ghosh S., Sathe G. M., Ammala C. E., Brown K. K., Ito R., LeDuc C., Solomon K., Fischer S. G., Leibel R. L., Positional cloning of "Lisch-like" a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genetics 2008 4 7 2-s2.0-48249083457 10.1371/journal.pgen.1000137 e1000137
30. Clee S. M., Yandell B. S., Schueler K. M., Rabaglia M. E., Richards O. C., Raines S. M., Kabara E. A., Klass D. M., Mui E. T. K., Stapleton D. S., Gray-Keller M. P., Young M. B., Stoehr J. P., Lan H., Boronenkov I., Raess P. W., Flowers M. T., Attie A. D., Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nature Genetics 2006 38 6 688 693 2-s2.0-33745260655 10.1038/ng1796 (Pubitemid 43927312)
31. Kawano K., Hirashima T., Mori S., Saitoh Y., Kurosumi M., Natori T., Spontaneous long-term hyperglycemic rat with diabetic complications: Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 1992 41 11 1422 1428 2-s2.0-0026722931
32. Deng A. Y., Genetic basis of polygenic hypertension. Human Molecular Genetics 2007 16 R195 R202 2-s2.0-38449108593 10.1093/hmg/ddm126