Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat

Mammalian Genome

Volumn 18, Issue 8, 2007, Pages 609-615

  Kose, Hiroyuki ^a   Bando, Yoshimi ^a   Izumi, Keisuke ^a   Yamada, Takahisa ^b   Matsumoto, Kozo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN;

ALLELE; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONGENIC STRAIN; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; GENE LOCUS; GENETIC EPISTASIS; GENETIC STRAIN; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HORMONE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; QUANTITATIVE TRAIT LOCUS; RAT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD GLUCOSE; CHROMOSOME MAPPING; DIABETES MELLITUS, EXPERIMENTAL; EPISTASIS, GENETIC; FEMALE; HYPERGLYCEMIA; ISLETS OF LANGERHANS; MALE; PANCREATITIS; PHENOTYPE; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED F344; RATS, INBRED OLETF;

RATTUS;

EID: 34848911901     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-007-9031-7     Document Type: Article

References (38)

1. Akhi M, Kose H, Matsumoto K (2005) Fine mapping of the hyperglycemic and obesity QTL by congenic strains suggests multiple loci on rat chromosome 14. J Med Invest 52:109-113
2. An P, Freedman BI, Hanis CL, Chen YD, Weder AB, et al. (2005) Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes 54:909-914
3. Araki E, Lipes MA, Patti ME, Bruning JC, Haag B 3rd, et al. (1994) Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-190
4. Bruning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, et al. (1998) A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 2:559-569
5. Cordell HJ (2002) Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet 11:2463-2468
6. Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, et al. (2006) The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab 4:291-302
7. Donath MY, Storling J, Maedler K, Mandrup-Poulsen T (2003) Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 81:455-470
8. Frankel WN, Schork NJ (1996) Who's afraid of epistasis? Nat Genet 14:371-373
9. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, et al. (1996) Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A 93:6231-6235
10. Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, et al. (1998) Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care 21:518-524
11. Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM (1994) Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A 91:4854-4858
12. Huan JN, Li J, Han Y, Chen K, Wu N, et al. (2003) Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. J Biol Chem 278:45638-45650
13. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ (1997) Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389:374-377
14. Katz EB, Stenbit AE, Hatton K, De Pinho R, Charron MJ (1995) Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 377:151-155
15. Kawano K, Hirashima T, Mori S, Kurosumi M, Saitoh Y (1991) A new rat strain with non-insulin-dependent diabetes mellitus, "OLETF." Rat News Lett 25:24-26
16. Kose H, Moralejo DH, Ogino T, Mizuno A, Yamada T, et al. (2002) Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Mamm Genome 13:558-562
17. Luo TH, Zhao Y, Li G, Yuan WT, Zhao JJ, et al. (2001) A genome-wide search for type II diabetes susceptibility genes in Chinese Hans. Diabetologia 44:501-506
18. Monti J, Plehn R, Schulz H, Ganten D, Kreutz R, et al. (2003) Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. Hum Mol Genet 12:435-439
19. Moore JH (2003) The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered 56:73-82
20. Moralejo DH, Wei S, Wei K, Weksler-Zangen S, Koike G, et al. (1998) Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long- Evans Tokushima Fatty rat. Proc Assoc Am Physicians 110:545-558
21. Nonogaki K, Fuller GM, Fuentes NL, Moser AH, Staprans I, et al. (1995) Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinology 136:2143-2149
22. Ogino T, Wei S, Wei K, Moralejo DH, Kose H, et al. (2000) Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF. Genomics 70:19-25
23. Okauchi N, Mizuno A, Yoshimoto S, Zhu M, Sano T, et al. (1995) Is caloric restriction effective in preventing diabetes mellitus in the Otsuka Long Evans Tokushima fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Diabetes Res Clin Pract 27:97-106
24. Oliver F, Christians JK, Liu X, Rhind S, Verma V, et al. (2005) Regulatory variation at glypican-3 underlies a major growth QTL in mice. PLoS Biol 3:e135
25. Perreault M, Marette A (2001) Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7:1138-1143
26. Pietropaolo M, Barinas-Mitchell E, Pietropaolo SL, Kuller LH, Trucco M, et al. (2000) Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes. Diabetes 49:32-38
27. Rapp JP, Garrett MR, Deng AY (1998) Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10. J Clin Invest 101:1591-1595
28. Reifsnyder PC, Churchill G, Leiter EH (2000) Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10:1568-1578
29. Saltiel AR (2001) New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104:517-529
30. Shima K, Shi K, Mizuno A, Sano T, Ishida K, et al. (1996) Exercise training has a long-lasting effect on prevention of non-insulin-dependent diabetes mellitus in Otsuka-Long-Evans-Tokushima Fatty rats. Metabolism 45:475-480
31. Skinner JA, Saltiel AR (2001) Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1. Biochem J 356:257-267
32. Syed MA, Barinas-Mitchell E, Pietropaolo SL, Zhang YJ, Henderson TS, et al. (2002) Is type 2 diabetes a chronic inflammatory/autoimmune disease? Diabetes Nutr Metab 15:68-83
33. Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, et al. (1994) Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372:182-186
34. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, et al. (2002) Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418:426-430
35. Wei S, Wei K, Moralejo DH, Ogino T, Koike G, et al. (1999) Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Mamm Genome 10:249-258
36. Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, et al. (2001) A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet 69:553-569
37. Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
38. Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782-787