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Volumn 280, Issue 1, 2012, Pages 76-84

CD4-CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation

Author keywords

CD8+ T cells; Double negative T cells (DN T cells); Interferon gamma (IFN ); Interleukin 2 (IL 2); Viral hepatitis

Indexed keywords

FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 2;

EID: 84871409561     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2012.11.010     Document Type: Article
Times cited : (7)

References (46)
  • 1
    • 1642410856 scopus 로고    scopus 로고
    • Virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
    • PubMed: 14996343
    • Lavanchy D., Hepatitis B. Virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J. Viral Hepat. 2004, 11:97-107. PubMed: 14996343.
    • (2004) J. Viral Hepat. , vol.11 , pp. 97-107
    • Lavanchy, D.1    Hepatitis, B.2
  • 3
    • 0023933449 scopus 로고
    • B. Hepatitis virus. The major etiology of hepatocellular carcinoma
    • PubMed: 2834034
    • Beasley R.P. B. Hepatitis virus. The major etiology of hepatocellular carcinoma. Cancer 1988, 61:1942-1956. PubMed: 2834034.
    • (1988) Cancer , vol.61 , pp. 1942-1956
    • Beasley, R.P.1
  • 4
    • 0141626825 scopus 로고    scopus 로고
    • Mechanisms of viral hepatitis induced liver injury
    • PubMed: 14527085
    • Yasunari N., Shuichi K. Mechanisms of viral hepatitis induced liver injury. Curr. Mol. Med. 2003, 3:537-544. PubMed: 14527085.
    • (2003) Curr. Mol. Med. , vol.3 , pp. 537-544
    • Yasunari, N.1    Shuichi, K.2
  • 5
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T Cells in autoimmmunity*
    • PubMed:10837065
    • Shevach E.M. Regulatory T Cells in autoimmmunity*. Annu. Rev. Immunol. 2000, 18:423-449. PubMed:10837065.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 6
    • 0035187182 scopus 로고    scopus 로고
    • Suppressor T cells - they're back and critical for regulation of autoimmunity!
    • PubMed:11722631
    • Chatenoud L., Salomon B., Bluestone J.A. Suppressor T cells - they're back and critical for regulation of autoimmunity!. Immunol. Rev. 2001, 182:149-163. PubMed:11722631.
    • (2001) Immunol. Rev. , vol.182 , pp. 149-163
    • Chatenoud, L.1    Salomon, B.2    Bluestone, J.A.3
  • 7
    • 0035191131 scopus 로고    scopus 로고
    • The role of CD4+ T-cell subsets in determining transplantation rejection or tolerance
    • PubMed: 11722632
    • Zelenika D., Adams E., Humm S., Lin C.Y., Waldmann H., Cobbold S.P. The role of CD4+ T-cell subsets in determining transplantation rejection or tolerance. Immunol. Rev. 2001, 182:164-179. PubMed: 11722632.
    • (2001) Immunol. Rev. , vol.182 , pp. 164-179
    • Zelenika, D.1    Adams, E.2    Humm, S.3    Lin, C.Y.4    Waldmann, H.5    Cobbold, S.P.6
  • 8
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+) CD4(+) regulatory cells that control intestinal inflammation
    • PubMed: 10899916
    • Read S., Malmstrom V., Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+) CD4(+) regulatory cells that control intestinal inflammation. J. Exp. Med. 2000, 192:295-302. PubMed: 10899916.
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 9
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+) CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • PubMed: 11812990
    • Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+) CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 2002, 3:135-142. PubMed: 11812990.
    • (2002) Nat. Immunol. , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 10
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • PubMed: 12658273
    • Bluestone J.A., Abbas A.K. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 2003, 3:253-257. PubMed: 12658273.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 11
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells
    • PubMed: 12612578
    • Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat. Immunol. 2003, 4:330-336. PubMed: 12612578.
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 12
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • PubMed: 12522256
    • Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061. PubMed: 12522256.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 13
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self
    • PubMed: 15785760
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 2005, 6:345-352. PubMed: 15785760.
    • (2005) Nat. Immunol. , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 14
    • 0035198718 scopus 로고    scopus 로고
    • Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes
    • PubMed: 11713466
    • Gonzalez A., Andre-Schmutz I., Carnaud C., Mathis D., Benoist C. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat. Immunol. 2001, 2:1117-1125. PubMed: 11713466.
    • (2001) Nat. Immunol. , vol.2 , pp. 1117-1125
    • Gonzalez, A.1    Andre-Schmutz, I.2    Carnaud, C.3    Mathis, D.4    Benoist, C.5
  • 15
    • 0034091286 scopus 로고    scopus 로고
    • [gamma][delta] cells: a right time and a right place for a conserved third way of protection
    • PubMed: 10837080
    • Hayday A.C. [gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 2000, 18:975-1026. PubMed: 10837080.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 975-1026
    • Hayday, A.C.1
  • 16
    • 56649112958 scopus 로고    scopus 로고
    • Characteristics of circulating T cell receptor gamma-delta T cells from individuals chronically infected with hepatitis B virus (HBV): an association between V(delta)2 subtype and chronic HBV infection
    • PubMed: 18954265
    • Chen M., Zhang D., Zhen W., Shi Q., Liu Y., Ling N., Peng M., Tang K., Hu P., Hu H., Ren H. Characteristics of circulating T cell receptor gamma-delta T cells from individuals chronically infected with hepatitis B virus (HBV): an association between V(delta)2 subtype and chronic HBV infection. J. Infect. Dis. 2008, 198:1643-1650. PubMed: 18954265.
    • (2008) J. Infect. Dis. , vol.198 , pp. 1643-1650
    • Chen, M.1    Zhang, D.2    Zhen, W.3    Shi, Q.4    Liu, Y.5    Ling, N.6    Peng, M.7    Tang, K.8    Hu, P.9    Hu, H.10    Ren, H.11
  • 17
    • 0033929005 scopus 로고    scopus 로고
    • Identification of a previously nknown antigen-specific regulatory T cell and its mechanism of suppression
    • PubMed: 0888927
    • Zhang Z.X., Yang L., Young K.J., DuTemple B., Zhang L. Identification of a previously nknown antigen-specific regulatory T cell and its mechanism of suppression. Nat. Med. 2000, 6:782-789. PubMed: 0888927.
    • (2000) Nat. Med. , vol.6 , pp. 782-789
    • Zhang, Z.X.1    Yang, L.2    Young, K.J.3    DuTemple, B.4    Zhang, L.5
  • 18
    • 0035575989 scopus 로고    scopus 로고
    • TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells
    • PubMed: 1714779
    • Priatel J.J., Utting O., Teh H.S. TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells. J. Immunol. 2001, 167:6188-6194. PubMed: 1714779.
    • (2001) J. Immunol. , vol.167 , pp. 6188-6194
    • Priatel, J.J.1    Utting, O.2    Teh, H.S.3
  • 19
    • 53149152263 scopus 로고    scopus 로고
    • Cutting edge: in vivo trogocytosis as a echanism of double negative regulatory T cell-mediated antigen specific suppression
    • PubMed: 18684915
    • Ford M.S., Young K.J., Gao J., Joe B., Zhang L. Cutting edge: in vivo trogocytosis as a echanism of double negative regulatory T cell-mediated antigen specific suppression. J. Immunol. 2008, 181:2271-2275. PubMed: 18684915.
    • (2008) J. Immunol. , vol.181 , pp. 2271-2275
    • Ford, M.S.1    Young, K.J.2    Gao, J.3    Joe, B.4    Zhang, L.5
  • 20
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • PubMed: 12522256
    • Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299(5609):1057-1061. PubMed: 12522256.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 21
    • 16244385911 scopus 로고    scopus 로고
    • Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    • PubMed: 15791617
    • Stoop J.N., van der Molen R.G., Baan C.C., van der Laan L.J., Kuipers E.J., Kusters J.G., Janssen H.L. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 2005, 41:771-778. PubMed: 15791617.
    • (2005) Hepatology , vol.41 , pp. 771-778
    • Stoop, J.N.1    van der Molen, R.G.2    Baan, C.C.3    van der Laan, L.J.4    Kuipers, E.J.5    Kusters, J.G.6    Janssen, H.L.7
  • 22
    • 33745323050 scopus 로고    scopus 로고
    • Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B
    • PubMed: 16785573
    • Xu D., Fu J., Jin L., Zhang H., Zhou C., Zou Z., Zhao J.M., Zhang B., Shi M., Ding X., Tang Z., Fu Y.X., Wang F.S. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J. Immunol. 2006, 177:739-747. PubMed: 16785573.
    • (2006) J. Immunol. , vol.177 , pp. 739-747
    • Xu, D.1    Fu, J.2    Jin, L.3    Zhang, H.4    Zhou, C.5    Zou, Z.6    Zhao, J.M.7    Zhang, B.8    Shi, M.9    Ding, X.10    Tang, Z.11    Fu, Y.X.12    Wang, F.S.13
  • 23
    • 7044247947 scopus 로고    scopus 로고
    • An immuno-modulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection
    • PubMed: 15486925
    • Cabrera R., Tu Z., Xu Y., Firpi R.J., Rosen H.R., Liu C., Nelson D.R. An immuno-modulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004, 40:1062-1071. PubMed: 15486925.
    • (2004) Hepatology , vol.40 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6    Nelson, D.R.7
  • 26
    • 33750814875 scopus 로고    scopus 로고
    • Double-negative T cells, activated by xenoantigen, lyse autologous B and T cells using a perforin/granzyme-dependent Fas-Fas ligand-independent pathway
    • PubMed: 17082607
    • Zhang Z.X., Ma Y., Wang H., He K.M., Garcia B., Madrenas J., Zhong R. Double-negative T cells, activated by xenoantigen, lyse autologous B and T cells using a perforin/granzyme-dependent Fas-Fas ligand-independent pathway. J. Immunol. 2006, 177:6920-6929. PubMed: 17082607.
    • (2006) J. Immunol. , vol.177 , pp. 6920-6929
    • Zhang, Z.X.1    Ma, Y.2    Wang, H.3    He, K.M.4    Garcia, B.5    Madrenas, J.6    Zhong, R.7
  • 27
    • 40549117001 scopus 로고    scopus 로고
    • Adoptive transfer of double negative T regulatory cells induces B-cell death in vivo and alters rejection pattern of rat-to-mouse heart transplantation
    • PubMed: 18333914
    • Ma Y., He K.M., Garcia B., Min W., Jevnikar A., Zhang Z.X. Adoptive transfer of double negative T regulatory cells induces B-cell death in vivo and alters rejection pattern of rat-to-mouse heart transplantation. Xenotransplantation 2008, 15:56-63. PubMed: 18333914.
    • (2008) Xenotransplantation , vol.15 , pp. 56-63
    • Ma, Y.1    He, K.M.2    Garcia, B.3    Min, W.4    Jevnikar, A.5    Zhang, Z.X.6
  • 28
  • 29
    • 77955354249 scopus 로고    scopus 로고
    • Double negative (CD3+ 4-8-) TCR alphabeta splenic cells from young NOD mice provide long-lasting protection against type 1 diabetes
    • PubMed: 20625402
    • Duncan B., Nazarov-Stoica C., Surls J., Kehl M., Bona C., Casares S., Brumeanu T.D. Double negative (CD3+ 4-8-) TCR alphabeta splenic cells from young NOD mice provide long-lasting protection against type 1 diabetes. PLoS One 2010, 5(7):e11427. PubMed: 20625402.
    • (2010) PLoS One , vol.5 , Issue.7
    • Duncan, B.1    Nazarov-Stoica, C.2    Surls, J.3    Kehl, M.4    Bona, C.5    Casares, S.6    Brumeanu, T.D.7
  • 31
    • 33750455823 scopus 로고    scopus 로고
    • Disparate immunoregulatory potentials for double-negative (CD4- CD8-) alpha beta and gamma delta T cells from human patients with cutaneous leishmaniasis
    • PubMed: 16923794
    • Antonelli L.R., Dutra W.O., Oliveira R.R., Torres K.C., Guimarães L.H., Bacellar O., Gollob K.J. Disparate immunoregulatory potentials for double-negative (CD4- CD8-) alpha beta and gamma delta T cells from human patients with cutaneous leishmaniasis. Infect. Immun. 2006, 74:6317-6323. PubMed: 16923794.
    • (2006) Infect. Immun. , vol.74 , pp. 6317-6323
    • Antonelli, L.R.1    Dutra, W.O.2    Oliveira, R.R.3    Torres, K.C.4    Guimarães, L.H.5    Bacellar, O.6    Gollob, K.J.7
  • 32
    • 0032055507 scopus 로고    scopus 로고
    • Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response
    • PubMed: 9531310
    • Ning Q., Brown D., Parodo J., Cattral M., Gorczynski R., Cole E., Fung L., Ding J.W., Liu M.F., Rotstein O., Phillips M.J., Levy G. Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response. J. Immunol. 1998, 160:3487-3493. PubMed: 9531310.
    • (1998) J. Immunol. , vol.160 , pp. 3487-3493
    • Ning, Q.1    Brown, D.2    Parodo, J.3    Cattral, M.4    Gorczynski, R.5    Cole, E.6    Fung, L.7    Ding, J.W.8    Liu, M.F.9    Rotstein, O.10    Phillips, M.J.11    Levy, G.12
  • 33
    • 0019813866 scopus 로고
    • Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
    • PubMed: 7308988
    • Knodell R.G., Ishak K.G., Black W.C., Chen T.S., Craig R., Kaplowitz N., Kiernan T.W., Wollman J. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981, 1:431-435. PubMed: 7308988.
    • (1981) Hepatology , vol.1 , pp. 431-435
    • Knodell, R.G.1    Ishak, K.G.2    Black, W.C.3    Chen, T.S.4    Craig, R.5    Kaplowitz, N.6    Kiernan, T.W.7    Wollman, J.8
  • 34
    • 4344560518 scopus 로고    scopus 로고
    • Cell culture and animal models of viral hepatitis Part I: hepatitis B.
    • PubMed:15224117
    • Guha C., Mohan S., Roy-Chowdhury N., Roy-Chowdhury J. Cell culture and animal models of viral hepatitis Part I: hepatitis B. Lab. Anim. (NY) 2004, 33(7):37-46. PubMed:15224117.
    • (2004) Lab. Anim. (NY) , vol.33 , Issue.7 , pp. 37-46
    • Guha, C.1    Mohan, S.2    Roy-Chowdhury, N.3    Roy-Chowdhury, J.4
  • 35
    • 15844390651 scopus 로고    scopus 로고
    • Cell culture models and animal models of viral hepatitis Part II: hepatitis C
    • PubMed:15685191
    • Guha C., Lee S.W., Chowdhury N.R., Chowdhury J.R. Cell culture models and animal models of viral hepatitis Part II: hepatitis C. Lab. Anim. (NY) 2005, 34(2):39-47. PubMed:15685191.
    • (2005) Lab. Anim. (NY) , vol.34 , Issue.2 , pp. 39-47
    • Guha, C.1    Lee, S.W.2    Chowdhury, N.R.3    Chowdhury, J.R.4
  • 38
    • 0031721786 scopus 로고    scopus 로고
    • Expression of the fgl2 and its protein product (prothrombinase) in tissues during murine hepatitis virus strain-3(MHV-3) infection
    • PubMed: 9782336
    • Ding J.W., Ning Q., Liu M.F., Lai A., Peltekian K., Fung L., Holloway C., Yeger H., Phillips M.J., Levy G.A. Expression of the fgl2 and its protein product (prothrombinase) in tissues during murine hepatitis virus strain-3(MHV-3) infection. Adv. Exp. Med. Biol. 1998, 440:609-618. PubMed: 9782336.
    • (1998) Adv. Exp. Med. Biol. , vol.440 , pp. 609-618
    • Ding, J.W.1    Ning, Q.2    Liu, M.F.3    Lai, A.4    Peltekian, K.5    Fung, L.6    Holloway, C.7    Yeger, H.8    Phillips, M.J.9    Levy, G.A.10
  • 39
    • 0033839077 scopus 로고    scopus 로고
    • Molecular and functional analysis of the human prothrombinase gene (HFGL2) and its role in viral hepatitis
    • PubMed: 10751347
    • Levy G.A., Liu M., Ding J., Yuwaraj S., Leibowitz J., Marsden P.A., Ning Q., Kovalinka A., Phillips M.J. Molecular and functional analysis of the human prothrombinase gene (HFGL2) and its role in viral hepatitis. Am. J. Pathol. 2000, 156:1217-1225. PubMed: 10751347.
    • (2000) Am. J. Pathol. , vol.156 , pp. 1217-1225
    • Levy, G.A.1    Liu, M.2    Ding, J.3    Yuwaraj, S.4    Leibowitz, J.5    Marsden, P.A.6    Ning, Q.7    Kovalinka, A.8    Phillips, M.J.9
  • 40
    • 33745645833 scopus 로고    scopus 로고
    • Novel mfgl2 antisense plasmid inhibits murine fgl2 expression and ameliorates murine hepatitis virus type 3-induced fulminant hepatitis in BALB/cJ mice
    • PubMed: 16776568
    • Zhu C., Sun Y., Luo X., Yan W., Xi D., Ning Q. Novel mfgl2 antisense plasmid inhibits murine fgl2 expression and ameliorates murine hepatitis virus type 3-induced fulminant hepatitis in BALB/cJ mice. Hum. Gene Ther. 2006, 17:589-600. PubMed: 16776568.
    • (2006) Hum. Gene Ther. , vol.17 , pp. 589-600
    • Zhu, C.1    Sun, Y.2    Luo, X.3    Yan, W.4    Xi, D.5    Ning, Q.6
  • 42
    • 0019521231 scopus 로고
    • Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice
    • PubMed:6270227
    • Levy G.A., Leibowitz J.L., Edgington T.S. Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice. J. Exp. Med. 1981, 154:1150-1163. PubMed:6270227.
    • (1981) J. Exp. Med. , vol.154 , pp. 1150-1163
    • Levy, G.A.1    Leibowitz, J.L.2    Edgington, T.S.3
  • 43
    • 34848827466 scopus 로고    scopus 로고
    • Regulatory T cells in viral hepatitis
    • PubMed:17828817
    • Eva B., Tobias B., Robert T. Regulatory T cells in viral hepatitis. World J. Gastroenterol. 2007, 13(36):4858-4864. PubMed:17828817.
    • (2007) World J. Gastroenterol. , vol.13 , Issue.36 , pp. 4858-4864
    • Eva, B.1    Tobias, B.2    Robert, T.3
  • 44
    • 79954431750 scopus 로고    scopus 로고
    • Characterization of the immunoregulatory function of human TCR-alphabeta+CD4- CD8- double-negative T cells
    • PubMed:21287552
    • Voelkl S., Gary R., Mackensen A. Characterization of the immunoregulatory function of human TCR-alphabeta+CD4- CD8- double-negative T cells. Eur. J. Immunol. 2011, 41:739-748. PubMed:21287552.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 739-748
    • Voelkl, S.1    Gary, R.2    Mackensen, A.3
  • 45
    • 0032076635 scopus 로고    scopus 로고
    • Potent and selective stimulation of memory-phenotype CD8+ T-cells in vivo by IL-15
    • PubMed: 9620680
    • Zhang X., Sun S., Hwang I., Tough D.F., Sprent J. Potent and selective stimulation of memory-phenotype CD8+ T-cells in vivo by IL-15. Immunity 1998, 8:591-599. PubMed: 9620680.
    • (1998) Immunity , vol.8 , pp. 591-599
    • Zhang, X.1    Sun, S.2    Hwang, I.3    Tough, D.F.4    Sprent, J.5


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