Characteristics of circulating T cell receptor γδ T cells from individuals chronically infected with hepatitis B virus (HBV): An association between Vδ2 subtype and chronic HBV infection

Journal of Infectious Diseases

Volumn 198, Issue 11, 2008, Pages 1643-1650

  Chen, Min ^a   Zhang, Dazhi ^b   Zhen, Weiqun ^b   Shi, Qingfeng ^b   Liu, Yi ^b   Ling, Ning ^b   Peng, Mingli ^a   Tang, Kaifu ^a   Hu, Peng ^a   Hu, Aidong ^a   Ren, Hong ^a,b  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CYTOKINE; GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CELLULAR IMMUNITY; CHRONIC HEPATITIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; CYTOTOXICITY TEST; FEMALE; FLOW CYTOMETRY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNOCOMPETENT CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS CARRIER;

ADOLESCENT; ADULT; ANTIGENS, CD45; CARRIER STATE; FEMALE; HEPATITIS B, CHRONIC; HUMANS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 56649112958     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/593065     Document Type: Article

References (28)

1. Bertoletti A, Gehring AJ. The immune response during hepatitis B virus infection. J Gen Virol 2006;87:1439-49.
2. + T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 2003; 77:68-76.
3. Bocher WO, Galun E, Marcus H, et al. Reduced hepatitis B virus surface antigen specific Th1 helper cell frequency of chronic HBV carriers is associated with a failure to produce antigen specific antibodies in the trimera mouse. Hepatology 2000; 31:480-7.
4. Hui CK, Lau GK. Immune system and hepatitis B virus infection. J Clin Virol 2005; 34:S44-8.
5. Akbar SM, Horiike N, Onji M, et al. Dendritic cells and chronic hepatitis virus carriers. Intervirology 2001; 44:199-208.
6. Chen M, Li YG, Zhang DZ, et al. Therapeutic effect of autologous dendritic cell vaccine on patients with chronic hepatitis B: a clinical study. World J Gastroenterol 2005; 11:1806-8.
7. Baron JL, Gardiner L, Nishimura S, et al. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 2002; 16:583-94.
8. Bertolino P, Klimpel G, Lemon SM. Hepatic inflammation and immunity: a summary of a conference on the function of the immune system within the liver. Hepatology 2000; 31:1374-8.
9. Pennington DJ, Silva-Santos B, Hayday AC. γδT cell development: having the strength to get there. Curr Opin Immunol 2005; 17:108-15.
10. Girardi M. Immunosurveillance and immunoregulation by γδ T cells. J Invest Dermatol 2006; 126:25-31.
11. Brandes M, Willimann K, Moser B. Professional antigen-presentation function by human gammadelta T cells. Science 2005; 309:264-8.
12. Poccia F, Agrati C, Martini F, et al. Antiviral reactivities of γδT cells. Microbes Infect 2005; 7:518-28.
13. Agrati C, D'Offizi G, Narciso P, et al. Vdelta1 T lymphocytes expressing a Th1 phenotype are the major gammadelta T cell subset infiltrating the liver of HCV-infected persons. Mol Med 2001; 7:11-9.
14. Agrati C, Alonzi T, De Santis R, et al. Activation of Vgamma9Vdelta2 T cells by non-peptidic antigens induces the inhibition of subgenomic HCV replication. Int Immunol 2006; 18:11-8.
15. Tseng CT, Miskovsky E, Houghton M, et al. Characterization of liver T-cell receptor gamma delta T cells obtained from individuals chronically infected with hepatitis C virus (HCV): evidence for these T cells playing a role in the liver pathology associated with HCV infections. Hepatology 2001; 33:1312-20.
16. Chen M, Peng ML, Shi QF, et al. Establishing a LO2 cell model with whole HBV gene transfection and analyzing its expressions of HLA-A, B, C and MICA/B [in Chinese]. Zhonghua Gan Zang Bing Za Zhi 2007; 15:417-21.
17. Born WK, Reardon CL, O'Brien RL. The function of γδT cells in innate immunity: current opinion in immunology 2006; 18:31-38.
18. Poccia F, Agrati C, Martini F, et al. Vgamma9Vdelta2 T cell-mediated non-cytolytic antiviral mechanisms and their potential for cell-based therapy. Immunol Lett 2005; 100:14-20.
19. Rossol R, Dobmeyer JM, Dobmeyer TS, et al. Increase in Vdelta1 + gammadelta T cells in the peripheral blood and bone marrow as a selective feature of HIV-1 but not other virus infections. Br J Haematol 1998; 100:728-34.
20. Chen ZW, Letvin NL. Vγ2Vγ2+ T cells and anti-microbial immune responses. Microbes Infect 2003; 5:491-98.
21. Holtmeier W, Kabelitz D. Gammadelta T cells link innate and adaptive immune responses. Chem Immunol Allergy 2005; 86:151-83.
22. Berndt A, Pieper J, Methner U. Circulating gamma delta T cells in response to Salmonella enterica serovar enteritidis exposure in chickens. Infect Immun 2006; 74:3967-78.
23. Jonasson R, Andersson M, Rasback T, et al. Immunological alterations during the clinical and recovery phases of experimental swine dysentery. J Med Microbiol 2006; 55:845-55.
24. Kabelitz D, Wesch D, He W. Perspectives of gammadelta T cells in tumor immunology. Cancer Res 2007; 67:5-8.
25. Bocher WO, Galun E, Marcus H, et al. Reduced hepatitis B virus surface antigen specific Th1 helper cell frequency of chronic HBV carriers is associated with a failure to produce antigen specific antibodies in the trimera mouse. Hepatology 2000; 31:480-7.
26. Regauer S, Beham-Schmid C. Detailed analysis of the T-cell lymphocytic infiltrate in penile lichen sclerosus: an immunohistochemical and molecular investigation. Histopathology 2006; 48:730-5.
27. Inagaki-Ohara K, Chinen T, Matsuzaki G, et al. Mucosal T cells bearing TCR gammadelta play a protective role in intestinal inflammation. J Immunol 2004; 173:1390-8.
28. Andrew EM, Newton DJ, Dalton JE, et al. Delineation of the function of a major gammadelta T cell subset during infection. J Immunol 2005; 175:1741-50.