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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 143-146

Inhibition of the human deacylase Sirtuin 5 by the indole GW5074

(3) Suenkel, Benjamin a Fischer, Frank a Steegborn, Clemens a

a UNIVERSITY OF BAYREUTH (Germany)

Author keywords

Deacetylase; Desuccinylase; Inhibitor; Sirt5; Sirtuin; Substrate specific inhibition

Indexed keywords

3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; EX 527; HISTONE DEACETYLASE INHIBITOR; HR 73; PEPTIDE; PROTEIN SERINE THREONINE KINASE INHIBITOR; SALERMIDE; SIRTINOL; SIRTUIN 5; SIRTUIN INHIBITOR; SRT 1720; SURAMIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEACETYLATION; DESUCCINYLATION; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; IC 50;

HUMANS; INDOLES; PHENOLS; PROTEIN BINDING; SIRTUINS; SUBSTRATE SPECIFICITY;

EID: 84871017552 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.10.136 Document Type: Article

Times cited : (46)

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