Inhibitors of the NAD+-dependent protein desuccinylase and demalonylase sirt5

ACS Medicinal Chemistry Letters

Volumn 3, Issue 12, 2012, Pages 1050-1053

  Maurer, Benjamin ^a   Rumpf, Tobias ^a   Scharfe, Michael ^b   Stolfa, Diana A ^a   Schmitt, Martin L ^a   He, Wenjuan ^c   Verdin, Eric ^c   Sippl, Wolfgang ^a,b   Jung, Manfred ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

Author keywords

AMC assay; desuccinylation; Sirt5; sirtinol; sirtuin

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CAMBINOL; DEMALONYLASE INHIBITOR; DESUCCINYLASE INHIBITOR; ENZYME INHIBITOR; EX 527; HR 103; HYDROLASE; LYSINE; NICOTINAMIDE; SIRTINOL; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 5; SURAMIN; THIOBARBITURIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CELL COMPARTMENTALIZATION; DEGENERATIVE DISEASE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME SUBSTRATE; GENE CONTROL; HUMAN; IC 50; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL;

EID: 84871253229     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml3002709     Document Type: Article

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