Co-aggregation of RNA binding proteins in ALS spinal motor neurons: Evidence of a common pathogenic mechanism

Acta Neuropathologica

Volumn 124, Issue 5, 2012, Pages 733-747

  Keller, Brian A ^a,b   Volkening, Kathryn ^a,b   Droppelmann, Cristian A ^b   Ang, Lee Cyn ^a   Rademakers, Rosa ^c   Strong, Michael J ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c MAYO CLINIC   (United States)

Author keywords

Amyotrophic lateral sclerosis; C9orf72; RGNEF; RNA binding proteins; Superoxide dismutase; Ubiquitination

Indexed keywords

ANTIBODY; C9ORF72 PROTEIN; FUSED IN SARCOMA PROTEIN; OPTINEURIN; PERIPHERIN; PHOSHORYLATED HIGH MOLECULAR WEIGHT NEUROFILAMENT; PROTEIN P62; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; RNA BINDING PROTEIN; SOD1 PROTEIN; TAR DNA BINDING PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CELL INCLUSION; COLORIMETRY; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MICROSCOPY; NEURONAL CYTOPLASMIC INCLUSION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SPINAL CORD MOTONEURON;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMYOTROPHIC LATERAL SCLEROSIS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMMUNOPRECIPITATION; INTERMEDIATE FILAMENT PROTEINS; MALE; MEMBRANE GLYCOPROTEINS; MICROSCOPY, CONFOCAL; MOTOR NEURONS; MUTATION; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; ORGANIC CHEMICALS; PROTEINS; RNA-BINDING PROTEIN FUS; RNA-BINDING PROTEINS; SPINAL CORD; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR TFIIIA;

EID: 84870994113     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-1035-z     Document Type: Article

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