Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression

Journal of Neuroscience

Volumn 27, Issue 30, 2007, Pages 7929-7938

  Lu, Liang ^a,d   Zheng, Lei ^a   Viera, Liliana ^e   Suswam, Esther ^a   Li, Yanyan ^a,d   Li, Xuelin ^a,d   Estévez, Alvaro G ^e,f   King, Peter H ^a,b,c,d,g  

^a The University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d BIRMINGHAM VA MEDICAL CENTER   (United States)

^e Department of Obstetrics Gynecology   (United States)

^f WEILL CORNELL MEDICAL COLLEGE   (United States)

^g NONE   (United States)

Author keywords

3 untranslated region; AU rich element; HuR translocation; Motor neurons; Posttranscriptional gene regulation; RNA binding proteins

Indexed keywords

ADENOSINE PHOSPHATE; COPPER ZINC SUPEROXIDE DISMUTASE; HUR PROTEIN; LUCIFERASE; MESSENGER RNA; MUTANT PROTEIN; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; URIDINE PHOSPHATE; VASCULOTROPIN;

3' UNTRANSLATED REGION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DOWN REGULATION; EXPERIMENTAL MODEL; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR PROBE; MOTONEURON; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; RNA STABILITY; TRANSGENIC MOUSE;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DOWN-REGULATION; MICE; MICE, TRANSGENIC; RNA, MESSENGER; SUPEROXIDE DISMUTASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34547476995     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1877-07.2007     Document Type: Article

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