Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis

Journal of Neurochemistry

Volumn 82, Issue 5, 2002, Pages 1118-1128

  Menzies, Fiona M ^a,c   Grierson, Andrew J ^b   Cookson, Mark R ^b   Heath, Paul R ^b   Tomkins, Janine ^b   Figlewicz, Denise A ^b   Ince, Paul G ^a   Shaw, Pamela J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF ROCHESTER   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Amyotrophic lateral sclerosis; Gene expression; Neurofilaments; SOD1

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; MESSENGER RNA;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; MOTONEURON; MOUSE; NEUROFILAMENT; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUMANS; INCLUSION BODIES; MICE; MICE, TRANSGENIC; MOTOR NEURONS; NEUROFILAMENT PROTEINS; RNA, MESSENGER; SPINAL CORD; SUPEROXIDE DISMUTASE; TRANSFECTION;

ANIMALIA; MUS MUSCULUS;

EID: 0036723914     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01045.x     Document Type: Article

References (47)

1. Glutamate slows axonal transport of neurofilaments in transfected neurons
2. Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis
3. Neurofilament light and polyadenylated mRNA levels are decreased in amyotrophic lateral sclerosis motor neurons
4. Phosphorylation of neurofilament heavy-chain side-arms by stress-activated protein kinase-1b/Jun N-terminal kinase-3
5. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
6. Similar poly (C)-sensitive RNA-binding complexes regulate the stability of the heavy and light neurofilament mRNAs
7. Characterization of ribonucleoprotein complexes and their binding sites on the neurofilament light subunit mRNA
8. Stability determinants are localized to the 3′-untranslated region and 3′-coding region of the neurofilament light subunit mRNA using a tetracycline-inducible promoter
9. Mutation in neurofilament transgene implicates RNA processing in the pathogenesis of neurodegenerative disease
10. p190RhoGEF binds to a destabilizing element in the 3′ untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript
11. Proximal axonal enlargement in motor neuron disease
12. Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons
13. From Charcot to SODI: Mechanisms of selective motor neuron death in ALS
14. Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: Role of poly (ADP-ribose) polymerase
15. Distribution and levels of insulin-like growth factor (IGF-I and IGF-II) and insulin receptor binding sites in the spinal cords of amyotrophic lateral sclerosis (ALS) patients
16. Ciliary neurotrophic factor receptor expression in spinal cord and motor cortex in amyotrophic lateral sclerosis
17. Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis
18. Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis
19. Glutamine synthetase activity and expression are not affected by the development of motor neuronopathy in the G93A SOD-1/ALS mouse
20. Effects of neurotrophic factors and cell substrates on the differentiation of a sympathoadrenal progenitor cell line
21. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
22. Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis
23. Amyotrophic lateral sclerosis associated with genetic abnormalities in the gene encoding Cu/Zn superoxide dismutase: Molecular pathology of five new cases, and comparison with previous reports and 73 sporadic cases of ALS
24. Phosphorylated high molecular weight neurofilament protein in the peripheral motor, sensory and sympathetic neuronal perikarya: System-dependent normal variations and changes in amyotrophic lateral sclerosis and multiple system atrophy
25. Cytoskeletal abnormalities in amyotrophic lateral sclerosis: Beneficial or detrimental effects?
26. Cloning and developmental expression of the murine neurofilament gene family
27. Activation of mitogen-activated protein kinases (Erk1 and Erk2) cascade results in phosphorylation of NF-M tail domains in transfected NIH 3T3 cells
28. Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells
29. Mitochondrial dysfunction in a cell culture model of amyotrophic lateral sclerosis
30. Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis
31. Deregulation of Cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions
32. Neutrophin switching in spinal motoneurons of amyotrophic lateral sclerosis
33. Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord
34. Axonal atrophy in aging is associated with a decline in neurofilament gene expression
35. Biochemical and immunological analyses of cytoskeletal domains of neurons
36. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
37. SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis
38. Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle
39. Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls
40. Deletion of 3′-untranslated region alters the level of mRNA expression of a neurofilament light subunit transgene
41. Neurofilament metabolism in sporadic amyotrophic lateral sclerosis
42. Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS)
43. Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M
44. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons
45. Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant
46. Characterization of neuronal intermediate filament protein expression in cervical spinal motor neurons in sporadic amyotrophic lateral sclerosis (ALS)
47. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria