Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis

Neurobiology of Aging

Volumn 34, Issue 1, 2013, Pages 248-262

  Droppelmann, Cristian A ^a   Keller, Brian A ^a   Campos Melo, Danae ^a   Volkening, Kathryn ^a,b   Strong, Michael J ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

Amyotrophic lateral sclerosis; NFL; P190RhoGEF; Protein aggregates; RGNEF; Rho guanine nucleotide exchange factor; RNA binding protein; RNA stability

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; NEUROFILAMENT PROTEIN; PROTEIN P62; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; TAR DNA BINDING PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING AFFINITY; CELL INCLUSION; CELL STRAIN HEK293; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; MOLECULAR PATHOLOGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA METABOLISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL LINE, TRANSFORMED; DNA-BINDING PROTEINS; FEMALE; GREEN FLUORESCENT PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMMUNOPRECIPITATION; INCLUSION BODIES; MALE; MICE; MIDDLE AGED; NEUROFILAMENT PROTEINS; PROTEIN BINDING; RNA STABILITY; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION; UBIQUITIN;

EID: 84868137686     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.06.021     Document Type: Article

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