Human low molecular weight neurofilament (NFL) mRNA interacts with a predicted p190RhoGEF homologue (RGNEF) in humans

Amyotrophic Lateral Sclerosis

Volumn 11, Issue 1-2, 2010, Pages 97-103

  Volkening, Kathryn ^a   Leystra Lantz, Cheryl ^a   Strong, Michael J ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

Amyotrophic lateral sclerosis; Intermediate filament; P190RhoGEF; Rho guanine nucleotide exchange factor (RGNEF); RNA binding protein

Indexed keywords

MESSENGER RNA; NEUROFILAMENT PROTEIN; PROTEIN P190RHOGEF; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BRAIN; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; NEUROFILAMENT; NEUROPATHOLOGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SPINAL CORD; TISSUE INTERACTION;

AMINO ACID SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CENTRAL NERVOUS SYSTEM; CLONING, MOLECULAR; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NEUROFILAMENT PROTEINS; RAS-GRF1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA STABILITY; RNA, MESSENGER;

EID: 77649317237     PISSN: 17482968     EISSN: 1471180X     Source Type: Journal    
DOI: 10.3109/17482960902995584     Document Type: Article

References (21)

1. Julien J-P. A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis. Biochem Cell Biol. 1995;73: 593-7.
2. Julien J-P. Neurofilament functions in health and disease. Curr Opin Neurol. 1999;9:554-60.
3. Meier J, Couillard-Després S, Jacomy H, Gravel C, Julien J-P. Extra neurofilament NF-L subunits rescue motor neuron disease caused by overexpression of the human NF-H gene in mice. J Neuropathol Exp Neurol. 1999;58:1099-110.
4. Beaulieu J-M, Jacomy H, Julien J-P. Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit. J Neurosci. 2000;20:5321-8.
5. Xao S, McLean J, Robertson J. Neuronal intermediate filaments and ALS: a new look at an old question. Biochim Biophys Acta. 2006;1762:1001-12.
6. Strong MJ, Kesavapany S, Pant HC. The pathobiology of amyotrophic lateral sclerosis: a proteinopathy? J Neuropathol Exp Neurol. 2005;64:649-64.
7. Bergeron C, Beric-Maskarel K, Muntasser S, Weyer L, Somerville M, Percy ME. Neurofilament light and polyadenylated mRNA levels are decreased in amyotrophic lateral sclerosis motor neurons. J Neuropathol Exp Neurol. 1994;53: 221-30.
8. Wong N, He BP, Strong MJ. Characterization of neuronal intermediate filament protein expression in cervical spinal motor neurons in sporadic amyotrophic lateral sclerosis (ALS). J Neuropathol Exp Neurol. 2000;59:972-82.
9. Menzies FM, Grierson AJ, Cookson MR, Heath PR, Tomkins J, Figlewicz DA, et al. Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis. J Neurochem. 2002;82: 1118-28.
10. Ge WW, Wen W, Strong WL, Leystra-Lantz C, Strong MJ. Mutant copper/zinc superoxide dismutase binds to and destabilizes human low molecular weight neurofilament mRNA. J Biol Chem. 2005;280:118-24.
11. Strong MJ, Volkening K, Hammond R, Yang W, Strong WL, Leystra-Lantz C, Shoesmith C. TDP-43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein Mol Cell Neurosci. 2007;35:320-7. (Pubitemid 46843567)
12. Ge WW, Volkening K, Leystra-Lantz C, Jaffe H, Strong MJ. 14-3-3 protein binds to the low molecular weight neurofilament (NFL) mRNA 3' UTR. Mol Cell Neurosci. 2007;34: 80-7.
13. Cañete-Soler R, Wu J, Zhai J, Shamim M, Schlaepfer WW. p190RhoGEF binds to a destabilizing element in the 3' untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript. J Biol Chem. 2001;276:32046-50.
14. Lin H, Zhai J, Schlaepfer WW. RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration. Human Molecular Genetics. 2005;14:3643-59.
15. Ohara O, Nagase T, Mitsui G, Kohga H, Kikuno R, Hiraoka S, et al. Characterization of the size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. DNA Res. 2002;9:47-57.
16. Cañete-Soler R, Schwartz ML, Hua Y, Schlaepfer WW. Stability determinants are localized to the 3'-untranslated region and 3'-coding region of the neurofilament light subunit mRNA using a tetracycline-inducible promoter. J Biol Chem. 1998;273:12650-4.
17. Li Y, Jiang Z, Chen H, Ma W-J. A modified quantitative EMSA and its application in the study of RNA-protein interactions. J Biochem Biophys Methods. 2004;60:85-96.
18. Thyagarajan A, Strong MJ, Szaro BG. Post-transcriptional regulation of neurofilaments in development and disease. Exp Cell Res. 2007;313:2088-97.
19. Stefanizzi I, Cañete-Soler R. Coregulation of light neurofilament mRNA by poly(A)-binding protein and aldolase C: implications for neurodegeneration. Brain Res. 2007;1139: 15-28.
20. Cañete-Soler R, Reddy KS, Tolan DR, Zhai J. Aldolases A and C are ribonucleolytic components of a neuronal complex that regulates the stability of the light-neurofilament mRNA. J Neurosci. 2005;25:4353-64.
21. Strong MJ, Leystra-Lantz C, Ge W. Intermediate filament steady state mRNA levels in amyotrophic lateral sclerosis (ALS). Biochem Biophys Res Comm. 2004;316:317-22.