An autopsy case of SOD1-related ALS with TDP-43 positive inclusions

Neurology

Volumn 77, Issue 22, 2011, Pages 1993-1995

  Okamoto, Y ^a   Ihara, M ^a   Urushitani, M ^b   Yamashita, H ^a   Kondo, T ^a   Tanigaki, A ^a   Oono, M ^a,b   Kawamata, J ^c   Ikemoto, A ^a   Kawamoto, Y ^a   Takahashi, R ^a   Ito, H ^a  

^a KYOTO UNIVERSITY   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GENOMIC DNA; MYELIN; TAR DNA BINDING PROTEIN;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPSY; BRAIN STEM; CASE REPORT; DNA DETERMINATION; DNA EXTRACTION; EXON; HUMAN; HUMAN TISSUE; HYPOGLOSSAL NUCLEUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEWY BODY; MALE; MEDULLA OBLONGATA; MISSENSE MUTATION; MOTONEURON; MUSCLE WEAKNESS; NEUROLOGIC EXAMINATION; PRIORITY JOURNAL; RESPIRATORY FAILURE;

EID: 80055026924     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31823a0cfc     Document Type: Article

References (7)

1. Neumann M, Sampathu DM, Kwong LK, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006;314:130-133. (Pubitemid 44547757)
2. Tan CF, Eguchi H, Tagawa A, et al. TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. Acta Neuropathol 2007;113:535-542. (Pubitemid 46672599)
3. Cudkowicz ME, McKenna-Yasek D, Sapp PE, et al. Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Ann Neurol 1997;41:210-221. (Pubitemid 27082102)
4. Urushitani M, Ezzi SA, Julien JP. Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 2007;104:2495-2500. (Pubitemid 46391424)
5. Gros-Louis F, Soucy G, Lariviere R, Julien JP. Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS. J Neurochem 2010;113:1188-1199.
6. Sumi H, Kato S, Mochimaru Y, Fujimura H, Etoh M, Sakoda S. Nuclear TAR DNA binding protein 43 expression in spinal cord neurons correlates with the clinical course in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 2009;68:37-47.
7. Bosco DA, Morfini G, Karabacak NM, et al. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci 2010; 13:1396-1403.