Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 19, 2010, Pages 8633-8638

  Tyedmers, Jens ^a,b   Treusch, Sebastian ^a,c   Dong, Jijun ^a   McCaffery, J Michael ^d   Bevis, Brooke ^a,c   Lindquist, Susan ^a,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Asymmetric damage distribution; Fiber fragmentation; IPOD (Insoluble Protein Deposit); Prion inheritance; Yeast prion

Indexed keywords

AMYLOID; GREEN FLUORESCENT PROTEIN; PRION PROTEIN; TRANSLATION TERMINATION FACTOR; TRANSLATION TERMINATION FACTOR SUP35; UNCLASSIFIED DRUG;

ARTICLE; CELL DIVISION; FRAGMENTATION REACTION; MEIOSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE;

AMYLOID; GREEN FLUORESCENT PROTEINS; MICROSCOPY; MODELS, BIOLOGICAL; PEPTIDE TERMINATION FACTORS; PHENOTYPE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION; SOLUBILITY; TIME FACTORS;

EID: 77952711519     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003895107     Document Type: Article

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