Decreased mRNA expression of PGC-1α and PGC-1αregulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS

Journal of Neuropathology and Experimental Neurology

Volumn 71, Issue 12, 2012, Pages 1064-1074

  Thau, Nadine ^a,b   Knippenberg, Sarah ^a   Körner, Sonja ^a   Rath, Klaus Jan ^a   Dengler, Reinhard ^a,b   Petri, Susanne ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Centre for Systems Neuroscience   (Germany)

Author keywords

Amyotrophic lateral sclerosis; Mitochondrial biogenesis; Mitochondrial dysfunction; Mitochondrial transcription factor A; Nuclear respiratory factor 1 2; Oxidative stress; Peroxisome proliferatorsYactivated receptor coactivator 1

Indexed keywords

CHOLINERGIC RECEPTOR; COPPER ZINC SUPEROXIDE DISMUTASE; GA BINDING PROTEIN; MESSENGER RNA; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

ADULT; AGED; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; MUSCLE TISSUE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SPINAL CORD;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HUMANS; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; NERVE TISSUE PROTEINS; NF-E2-RELATED FACTOR 1; NUCLEAR RESPIRATORY FACTORS; RNA, MESSENGER; SPINAL CORD; STATISTICS, NONPARAMETRIC; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS;

EID: 84870848609     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e318275df4b     Document Type: Article

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