Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS)

Behavioural Brain Research

Volumn 213, Issue 1, 2010, Pages 82-87

  Knippenberg, Sarah ^a,b   Thau, Nadine ^a,b   Dengler, Reinhard ^a,b   Petri, Susanne ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

ALS; Behaviour; Footprint analyses; G93A; Gender; Rotarod; Survival

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIORAL RESEARCH; BODY WEIGHT; CONTROLLED STUDY; DISEASE COURSE; FOOT; GAIT; GENERAL CONDITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ROTAROD TEST; RUNNING; SYMPTOM; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; DISABILITY EVALUATION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; GAIT; HUMANS; MALE; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; NEUROPSYCHOLOGICAL TESTS; SEX FACTORS; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 77953360032     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.04.042     Document Type: Article

References (19)

1. Barneoud P., Lolivier J., Sanger D.J., Scatton B., Moser P. Quantitative motor assessment in FALS mice: a longitudinal study. Neuroreport 1997, 8:2861-2865.
2. Basso D.M., Beattie M.S., Bresnahan J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995, 12:1-21.
3. Bruijn L.I., Miller T.M., Cleveland D.W. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 2004, 27:723-749.
4. Choi C.I., Lee Y.D., Gwag B.J., Cho S.I., Kim S.S., Suh-Kim H. Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice. J Neurol Sci 2008, 268:40-47.
5. Dasari V.R., Spomar D.G., Gondi C.S., Sloffer C.A., Saving K.L., Gujrati M., et al. Axonal remyelination by cord blood stem cells after spinal cord injury. J Neurotrauma 2007, 24:391-410.
6. Dijkstra J.R., Meek M.F., Robinson P.H., Gramsbergen A. Methods to evaluate functional nerve recovery in adult rats: walking track analysis, video analysis and the withdrawal reflex. J Neurosci Methods 2000, 96:89-96.
7. Dobrowolny G., Giacinti C., Pelosi L., Nicoletti C., Winn N., Barberi L., et al. Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. J Cell Biol 2005, 168:193-199.
8. Dupuis L., Oudart H., Rene F., Gonzalez de Aguilar J.L., Loeffler J.P. Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model. Proc Natl Acad Sci USA 2004, 101:11159-11164.
9. Garbuzova-Davis S., Willing A.E., Milliken M., Saporta S., Zigova T., Cahill D.W., et al. Positive effect of transplantation of hNT neurons (NTera 2/D1 cell-line) in a model of familial amyotrophic lateral sclerosis. Exp Neurol 2002, 174:169-180.
10. Gurney M.E., Pu H., Chiu A.Y., Dal Canto M.C., Polchow C.Y., Alexander D.D., et al. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science 1994, 264:1772-1775.
11. Habisch H.J., Janowski M., Binder D., Kuzma-Kozakiewicz M., Widmann A., Habich A., et al. Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects. J Neural Transm 2007, 114:1395-1406.
12. Ikeda R., Kurokawa M.S., Chiba S., Yoshikawa H., Ide M., Tadokoro M., et al. Transplantation of neural cells derived from retinoic acid-treated cynomolgus monkey embryonic stem cells successfully improved motor function of hemiplegic mice with experimental brain injury. Neurobiol Dis 2005, 20:38-48.
13. Kirkinezos I.G., Hernandez D., Bradley W.G., Moraes C.T. Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis. Ann Neurol 2003, 53:804-807.
14. Klapdor K., Dulfer B.G., Hammann A., Van der Staay F.J. A low-cost method to analyse footprint patterns. J Neurosci Methods 1997, 75:49-54.
15. Ludolph A.C., Bendotti C., Blaugrund E., Chio A., Greensmith L., Loeffler J.P., et al. Guidelines for preclinical animal research in ALS/MND: a consensus meeting. Amyotroph Lateral Scler 2010, 11:38-45.
16. Ludolph A.C., Bendotti C., Blaugrund E., Hengerer B., Loffler J.P., Martin J., et al. Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop. Amyotroph Lateral Scler 2007, 8:217-223.
17. Pasinelli P., Brown R.H. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci 2006, 7:710-723.
18. Vercelli A., Mereuta O.M., Garbossa D., Muraca G., Mareschi K., Rustichelli D., et al. Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 2008, 31:395-405.
19. Weydt P., Hong S.Y., Kliot M., Moller T. Assessing disease onset and progression in the SOD1 mouse model of ALS. Neuroreport 2003, 14:1051-1054.