Aromatic Core Extension in the Series of N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands: Increased Telomere Damage, Antitumor Activity, and Strong Selectivity for Neoplastic over Healthy Cells

ChemMedChem

Volumn 7, Issue 12, 2012, Pages 2144-2154

  Franceschin, Marco ^a   Rizzo, Angela ^b   Casagrande, Valentina ^a   Salvati, Erica ^b   Alvino, Antonello ^a   Altieri, Alessandro ^a   Ciammaichella, Alina ^a   Iachettini, Sara ^b   Leonetti, Carlo ^b   Ortaggi, Giancarlo ^a   Porru, Manuela ^b   Bianco, Armandodoriano ^a   Biroccio, Annamaria ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Antitumor agents; Biological activity; Cancer; DNA damage; G quadruplexes

Indexed keywords

ANTINEOPLASTIC AGENT; GUANINE QUADRUPLEX; N,N' BIS[2 (1 PIPERIDINO) ETHYL] 1 (1 PIPERIDINYL) 6 [2 (1 PIPERIDINO) ETHYL]BENZO[GHI]PERYLENE 3,4:9,10 TETRACARBOXYLIC DIIMIDE; N,N' BIS[2 (1 PIPERIDINO) ETHYL] 1 (1 PIPERIDINYL) 7 [3 (1 PIPERIDINO)BUTINYL]PERYLENE 3,4:9,10 TETRACARBOXYLIC DIIMIDE; N,N' BIS[2 (1 PIPERIDINO)ETHYL] 1 (1 PIPERIDINYL) 6 [2 (1 PIPERIDINO)ETHYL]BENZO[GHI]PERYLENE 3,4:9,10 TETRACARBOXYLIC DIIMIDE; N,N' BIS[2 (1 PIPERIDINO)ETHYL] 1 (1 PIPERIDINYL) 7 BROMOPERYLENE 3,4:9,10 TETRACARBOXYLIC DIIMIDE; PERYLENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHROMOSOME DAMAGE; DNA DAMAGE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TELOMERE; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; G-QUADRUPLEXES; HUMANS; NEOPLASMS; PERYLENE; POLYCYCLIC COMPOUNDS; TELOMERE;

EID: 84870275680     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200348     Document Type: Article

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