-
2
-
-
3042798442
-
The increased prevalence of allergy and the hygiene hypothesis: Missing immune deviation, reduced immune suppression, or both?
-
Romagnani, S. The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology, 2004, 112, 352-363.
-
(2004)
Immunology
, vol.112
, pp. 352-363
-
-
Romagnani, S.1
-
3
-
-
31344461659
-
Innate immune recognition of viral infection
-
Kawai, T.; Akira, S. Innate immune recognition of viral infection. Nat. Immunol., 2006, 7, 131-137.
-
(2006)
Nat. Immunol
, vol.7
, pp. 131-137
-
-
Kawai, T.1
Akira, S.2
-
4
-
-
0037136585
-
Environmental exposure to endotoxin and its relation to asthma in school-age children
-
Allergy and Endotoxin Study Team
-
Braun-Fahrlander, C.; Riedler, J.; Herz, U.; Eder, W.; Waser, M.; Grize, L.; Maisch, S.; Carr, D.; Gerlach, F.; Bufe, A.; Lauener, R. P.; Schierl, R.; Renz, H.; Nowak, D.; von Mutius, E.; Allergy and Endotoxin Study Team. Environmental exposure to endotoxin and its relation to asthma in school-age children. N. Engl. J. Med., 2002, 347, 869-877.
-
(2002)
N. Engl. J. Med
, vol.347
, pp. 869-877
-
-
Braun-Fahrlander, C.1
Riedler, J.2
Herz, U.3
Eder, W.4
Waser, M.5
Grize, L.6
Maisch, S.7
Carr, D.8
Gerlach, F.9
Bufe, A.10
Lauener, R.P.11
Schierl, R.12
Renz, H.13
Nowak, D.14
von Mutius, E.15
-
5
-
-
77951196379
-
Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
-
Cherfils-Vicini, J.; Platonova, S.; Gillard, M.; Laurans, L.; Validire, P.; Caliandro, R.; Magdeleinat, P.; Mami-Chouaib, F.; Dieu-Nosjean, M. C.; Fridman, W. H.; Damotte, D.; Sautes-Fridman, C.; Cremer, I. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J. Clin. Invest., 2010, 120, 1285-1297.
-
(2010)
J. Clin. Invest
, vol.120
, pp. 1285-1297
-
-
Cherfils-Vicini, J.1
Platonova, S.2
Gillard, M.3
Laurans, L.4
Validire, P.5
Caliandro, R.6
Magdeleinat, P.7
Mami-Chouaib, F.8
Dieu-Nosjean, M.C.9
Fridman, W.H.10
Damotte, D.11
Sautes-Fridman, C.12
Cremer, I.13
-
6
-
-
78650921978
-
Toll-like receptor 7 activation reduces the contractile response of airway smooth muscle
-
Ekman, A. K.; Adner, M.; Cardell, L. O. Toll-like receptor 7 activation reduces the contractile response of airway smooth muscle. Eur. J. Pharmacol., 2011, 652, 145-151.
-
(2011)
Eur. J. Pharmacol
, vol.652
, pp. 145-151
-
-
Ekman, A.K.1
Adner, M.2
Cardell, L.O.3
-
7
-
-
12444341806
-
Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8
-
Gorden, K. B.; Gorski, K. S.; Gibson, S. J.; Kedl, R. M.; Kieper, W. C.; Qiu, X.; Tomai, M. A.; Alkan, S. S.; Vasilakos, J. P. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J. Immunol., 2005, 174, 1259-1268.
-
(2005)
J. Immunol
, vol.174
, pp. 1259-1268
-
-
Gorden, K.B.1
Gorski, K.S.2
Gibson, S.J.3
Kedl, R.M.4
Kieper, W.C.5
Qiu, X.6
Tomai, M.A.7
Alkan, S.S.8
Vasilakos, J.P.9
-
8
-
-
22544473593
-
TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production
-
Hart, O. M.; Athie-Morales, V.; O'Connor, G. M.; Gardiner, C. M. TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J. Immunol., 2005, 175, 1636-1642.
-
(2005)
J. Immunol
, vol.175
, pp. 1636-1642
-
-
Hart, O.M.1
Athie-Morales, V.2
O'Connor, G.M.3
Gardiner, C.M.4
-
9
-
-
0141958218
-
Expression and function of Toll-like receptors in eosinophils: Activation by Toll-like receptor 7 ligand
-
Nagase, H.; Okugawa, S.; Ota, Y.; Yamaguchi, M.; Tomizawa, H.; Matsushima, K.; Ohta, K.; Yamamoto, K.; Hirai, K. Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand. J. Immunol., 2003, 171, 3977-3982.
-
(2003)
J. Immunol
, vol.171
, pp. 3977-3982
-
-
Nagase, H.1
Okugawa, S.2
Ota, Y.3
Yamaguchi, M.4
Tomizawa, H.5
Matsushima, K.6
Ohta, K.7
Yamamoto, K.8
Hirai, K.9
-
10
-
-
22544450733
-
Direct stimulation of human T cells via TLR5 and TLR7/8: Flagellin and R-848 up-regulate proliferation and IFNgamma production by memory CD4+ T cells
-
Caron, G.; Duluc, D.; Fremaux, I.; Jeannin, P.; David, C.; Gascan, H.; Delneste, Y. Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFNgamma production by memory CD4+ T cells. J. Immunol., 2005, 175, 1551-1557.
-
(2005)
J. Immunol
, vol.175
, pp. 1551-1557
-
-
Caron, G.1
Duluc, D.2
Fremaux, I.3
Jeannin, P.4
David, C.5
Gascan, H.6
Delneste, Y.7
-
11
-
-
1542317550
-
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
-
Diebold, S. S.; Kaisho, T.; Hemmi, H.; Akira, S.; Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science, 2004, 303, 1529-1531.
-
(2004)
Science
, vol.303
, pp. 1529-1531
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis e Sousa, C.5
-
12
-
-
1842631428
-
Recognition of singlestranded RNA viruses by Toll-like receptor 7
-
Lund, J. M.; Alexopoulou, L.; Sato, A.; Karow, M.; Adams, N. C.; Gale, N. W.; Iwasaki, A.; Flavell, R. A. Recognition of singlestranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. U. S. A., 2004, 101, 5598-5603.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A
, vol.101
, pp. 5598-5603
-
-
Lund, J.M.1
Alexopoulou, L.2
Sato, A.3
Karow, M.4
Adams, N.C.5
Gale, N.W.6
Iwasaki, A.7
Flavell, R.A.8
-
13
-
-
0032556660
-
Respiratory tract viral infections in inner-city asthmatic adults
-
Atmar, R. L.; Guy, E.; Guntupalli, K. K.; Zimmerman, J. L.; Bandi, V. D.; Baxter, B. D.; Greenberg, S. B. Respiratory tract viral infections in inner-city asthmatic adults. Arch. Intern. Med., 1998, 158, 2453-2459.
-
(1998)
Arch. Intern. Med
, vol.158
, pp. 2453-2459
-
-
Atmar, R.L.1
Guy, E.2
Guntupalli, K.K.3
Zimmerman, J.L.4
Bandi, V.D.5
Baxter, B.D.6
Greenberg, S.B.7
-
14
-
-
0028990124
-
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
-
Johnston, S. L.; Pattemore, P. K.; Sanderson, G.; Smith, S.; Lampe, F.; Josephs, L.; Symington, P.; O'Toole, S.; Myint, S. H.; Tyrrell, D. A. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ, 1995, 310, 1225-1229.
-
(1995)
BMJ
, vol.310
, pp. 1225-1229
-
-
Johnston, S.L.1
Pattemore, P.K.2
Sanderson, G.3
Smith, S.4
Lampe, F.5
Josephs, L.6
Symington, P.7
O'Toole, S.8
Myint, S.H.9
Tyrrell, D.A.10
-
15
-
-
0034521180
-
Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection
-
Gern, J. E.; Vrtis, R.; Grindle, K. A.; Swenson, C.; Busse, W. W. Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection. Am. J. Respir. Crit. Care Med., 2000, 162, 2226-2231.
-
(2000)
Am. J. Respir. Crit. Care Med
, vol.162
, pp. 2226-2231
-
-
Gern, J.E.1
Vrtis, R.2
Grindle, K.A.3
Swenson, C.4
Busse, W.W.5
-
16
-
-
51649109114
-
Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production
-
Message, S. D.; Laza-Stanca, V.; Mallia, P.; Parker, H. L.; Zhu, J.; Kebadze, T.; Contoli, M.; Sanderson, G.; Kon, O. M.; Papi, A.; Jeffery, P. K.; Stanciu, L. A.; Johnston, S. L. Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 13562-13567.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A
, vol.105
, pp. 13562-13567
-
-
Message, S.D.1
Laza-Stanca, V.2
Mallia, P.3
Parker, H.L.4
Zhu, J.5
Kebadze, T.6
Contoli, M.7
Sanderson, G.8
Kon, O.M.9
Papi, A.10
Jeffery, P.K.11
Stanciu, L.A.12
Johnston, S.L.13
-
17
-
-
79955387771
-
A tryptophan-rich motif in the human parainfluenza virus type 2 V protein is critical for the blockade of toll-like receptor 7 (TLR7)- and TLR9- dependent signaling
-
Kitagawa, Y.; Yamaguchi, M.; Zhou, M.; Komatsu, T.; Nishio, M.; Sugiyama, T.; Takeuchi, K.; Itoh, M.; Gotoh, B. A tryptophan-rich motif in the human parainfluenza virus type 2 V protein is critical for the blockade of toll-like receptor 7 (TLR7)- and TLR9- dependent signaling. J. Virol., 2011, 85, 4606-4611.
-
(2011)
J. Virol
, vol.85
, pp. 4606-4611
-
-
Kitagawa, Y.1
Yamaguchi, M.2
Zhou, M.3
Komatsu, T.4
Nishio, M.5
Sugiyama, T.6
Takeuchi, K.7
Itoh, M.8
Gotoh, B.9
-
18
-
-
57149098273
-
Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders
-
Moller-Larsen, S.; Nyegaard, M.; Haagerup, A.; Vestbo, J.; Kruse, T. A.; Borglum, A. D. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax, 2008, 63, 1064-1069.
-
(2008)
Thorax
, vol.63
, pp. 1064-1069
-
-
Moller-Larsen, S.1
Nyegaard, M.2
Haagerup, A.3
Vestbo, J.4
Kruse, T.A.5
Borglum, A.D.6
-
19
-
-
75149113310
-
Toll-like receptor 7 function is reduced in adolescents with asthma
-
Roponen, M.; Yerkovich, S. T.; Hollams, E.; Sly, P. D.; Holt, P. G.; Upham, J. W. Toll-like receptor 7 function is reduced in adolescents with asthma. Eur. Respir. J., 2010, 35, 64-71.
-
(2010)
Eur. Respir. J
, vol.35
, pp. 64-71
-
-
Roponen, M.1
Yerkovich, S.T.2
Hollams, E.3
Sly, P.D.4
Holt, P.G.5
Upham, J.W.6
-
20
-
-
81755165915
-
The pharmacogenetics and pharmacogenomics of asthma therapy
-
Tse, S. M.; Tantisira, K.; Weiss, S. T. The pharmacogenetics and pharmacogenomics of asthma therapy. Pharmacogenomics J., 2011, 11, 383-392.
-
(2011)
Pharmacogenomics J
, vol.11
, pp. 383-392
-
-
Tse, S.M.1
Tantisira, K.2
Weiss, S.T.3
-
21
-
-
77957768543
-
Tiotropium bromide step-up therapy for adults with uncontrolled asthma
-
National Heart, Lung, and Blood Institute Asthma Clinical Research Network
-
Peters, S. P.; Kunselman, S. J.; Icitovic, N.; Moore, W. C.; Pascual, R.; Ameredes, B. T.; Boushey, H. A.; Calhoun, W. J.; Castro, M.; Cherniack, R. M.; Craig, T.; Denlinger, L.; Engle, L. L.; DiMango, E. A.; Fahy, J. V.; Israel, E.; Jarjour, N.; Kazani, S. D.; Kraft, M.; Lazarus, S. C.; Lemanske, R. F., Jr; Lugogo, N.; Martin, R. J.; Meyers, D. A.; Ramsdell, J.; Sorkness, C. A.; Sutherland, E. R.; Szefler, S. J.; Wasserman, S. I.; Walter, M. J.; Wechsler, M. E.; Chinchilli, V. M.; Bleecker, E. R.; National Heart, Lung, and Blood Institute Asthma Clinical Research Network. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N. Engl. J. Med., 2010, 363, 1715-1726.
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 1715-1726
-
-
Peters, S.P.1
Kunselman, S.J.2
Icitovic, N.3
Moore, W.C.4
Pascual, R.5
Ameredes, B.T.6
Boushey, H.A.7
Calhoun, W.J.8
Castro, M.9
Cherniack, R.M.10
Craig, T.11
Denlinger, L.12
Engle, L.L.13
Dimango, E.A.14
Fahy, J.V.15
Israel, E.16
Jarjour, N.17
Kazani, S.D.18
Kraft, M.19
Lazarus, S.C.20
Lemanske Jr., R.F.21
Lugogo, N.22
Martin, R.J.23
Meyers, D.A.24
Ramsdell, J.25
Sorkness, C.A.26
Sutherland, E.R.27
Szefler, S.J.28
Wasserman, S.I.29
Walter, M.J.30
Wechsler, M.E.31
Chinchilli, V.M.32
Bleecker, E.R.33
more..
-
24
-
-
77958098728
-
-
American Lung Association, Accessed March 7, 2012
-
American Lung Association: Asthma in Adults Fact Sheet. http://www.lung.org/lung-disease/asthma/resources/facts-andfigures/asthma-in-adults.html [Accessed March 7, 2012].
-
Asthma In Adults Fact Sheet
-
-
-
25
-
-
34347399259
-
Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies
-
Pockros, P. J.; Guyader, D.; Patton, H.; Tong, M. J.; Wright, T.; McHutchison, J. G.; Meng, T. C. Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. J. Hepatol., 2007, 47, 174-182.
-
(2007)
J. Hepatol
, vol.47
, pp. 174-182
-
-
Pockros, P.J.1
Guyader, D.2
Patton, H.3
Tong, M.J.4
Wright, T.5
McHutchison, J.G.6
Meng, T.C.7
-
26
-
-
37249041922
-
First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer
-
Dudek, A. Z.; Yunis, C.; Harrison, L. I.; Kumar, S.; Hawkinson, R.; Cooley, S.; Vasilakos, J. P.; Gorski, K. S.; Miller, J. S. First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer. Clin. Cancer Res., 2007, 13, 7119-7125.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 7119-7125
-
-
Dudek, A.Z.1
Yunis, C.2
Harrison, L.I.3
Kumar, S.4
Hawkinson, R.5
Cooley, S.6
Vasilakos, J.P.7
Gorski, K.S.8
Miller, J.S.9
-
27
-
-
58249094472
-
Influence of toll-like receptor ligands on the dendritic cell-T cell interactions: Therapeutic options for allergic diseases
-
Bullens, D. M. A.; Ceuppens J. L. Influence of toll-like receptor ligands on the dendritic cell-T cell interactions: therapeutic options for allergic diseases. Inflamm. Allergy Drug Targets, 2008, 7, 211-216.
-
(2008)
Inflamm. Allergy Drug Targets
, vol.7
, pp. 211-216
-
-
Bullens, D.M.A.1
Ceuppens, J.L.2
-
28
-
-
38349088595
-
TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders
-
Karlsson, L.; Sun, S.; Rao, N. L.; Venable, J.; Thurmond, R. TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm. Allergy Drug Targets, 2007, 6, 223-235.
-
(2007)
Inflamm. Allergy Drug Targets
, vol.6
, pp. 223-235
-
-
Karlsson, L.1
Sun, S.2
Rao, N.L.3
Venable, J.4
Thurmond, R.5
-
29
-
-
0036008014
-
Small antiviral compounds activate immune cells via the TLR7 MyD88- dependent signaling pathway
-
Hemmi, H.; Kaisho, T.; Takeuchi, O.; Sato, S.; Sanjo, H.; Hoshino, K.; Horiuchi, T.; Tomizawa, H.; Takeda, K.; Akira, S. Small antiviral compounds activate immune cells via the TLR7 MyD88- dependent signaling pathway. Nat. Immunol., 2002, 3, 196-200.
-
(2002)
Nat. Immunol
, vol.3
, pp. 196-200
-
-
Hemmi, H.1
Kaisho, T.2
Takeuchi, O.3
Sato, S.4
Sanjo, H.5
Hoshino, K.6
Horiuchi, T.7
Tomizawa, H.8
Takeda, K.9
Akira, S.10
-
30
-
-
0038651180
-
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
-
Lee, J.; Chuang, T. H.; Redecke, V.; She, L.; Pitha, P. M.; Carson, D. A.; Raz, E.; Cottam, H. B. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. U. S. A., 2003, 100, 6646-6651.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A
, vol.100
, pp. 6646-6651
-
-
Lee, J.1
Chuang, T.H.2
Redecke, V.3
She, L.4
Pitha, P.M.5
Carson, D.A.6
Raz, E.7
Cottam, H.B.8
-
31
-
-
12444283331
-
Synthesis and structure-activity relationships of 2-substituted-8- hydroxyadenine derivatives as orally available interferon inducers without emetic side effects
-
Isobe, Y.; Tobe, M.; Ogita, H.; Kurimoto, A.; Ogino, T.; Kawakami, H.; Takaku, H.; Sajiki, H.; Hirota, K.; Hayashi, H. Synthesis and structure-activity relationships of 2-substituted-8- hydroxyadenine derivatives as orally available interferon inducers without emetic side effects. Bioorg. Med. Chem., 2003, 11, 3641-3647.
-
(2003)
Bioorg. Med. Chem
, vol.11
, pp. 3641-3647
-
-
Isobe, Y.1
Tobe, M.2
Ogita, H.3
Kurimoto, A.4
Ogino, T.5
Kawakami, H.6
Takaku, H.7
Sajiki, H.8
Hirota, K.9
Hayashi, H.10
-
33
-
-
0031912740
-
Airway Inflammation In Mild Intermittent and In Persistent Asthma
-
Vignola, A. M.; Chanez, P.; Campbell, A. M.; Souques, F.; Lebel, B.; Enander, I.; Bousquet, J. Airway inflammation in mild intermittent and in persistent asthma. Am. J. Respir. Crit. Care Med., 1998, 157, 403-409.
-
(1998)
Am. J. Respir. Crit. Care Med
, vol.157
, pp. 403-409
-
-
Vignola, A.M.1
Chanez, P.2
Campbell, A.M.3
Souques, F.4
Lebel, B.5
Enander, I.6
Bousquet, J.7
-
34
-
-
84859904767
-
Upping the antedrug: Is a novel anti-inflammatory Toll-like receptor 7 agonist also a bronchodilator?
-
Kaufman, E. H.; Jacoby, D. B. Upping the antedrug: is a novel anti-inflammatory Toll-like receptor 7 agonist also a bronchodilator? Br. J. Pharmacol., 2012, 166, 569-572.
-
(2012)
Br. J. Pharmacol
, vol.166
, pp. 569-572
-
-
Kaufman, E.H.1
Jacoby, D.B.2
-
35
-
-
33646824868
-
Treatment of allergic airway inflammation and hyperresponsiveness by imiquimod modulating transcription factors T-bet and GATA-3
-
Bian, T.; Yin, K. S.; Jin, S. X.; Zhang, X. L.; Zhou, J. Y.; Ma, X. Q.; Hu, J. J.; De, W. Treatment of allergic airway inflammation and hyperresponsiveness by imiquimod modulating transcription factors T-bet and GATA-3. Chin. Med. J. (Engl), 2006, 119, 640-648.
-
(2006)
Chin. Med. J. (Engl)
, vol.119
, pp. 640-648
-
-
Bian, T.1
Yin, K.S.2
Jin, S.X.3
Zhang, X.L.4
Zhou, J.Y.5
Ma, X.Q.6
Hu, J.J.7
De, W.8
-
36
-
-
33645526656
-
Imiquimod attenuates airway inflammation and decreases the expression of thymus and activation regulated chemokine in allergic asthmatic mice
-
Jin, S. X.; Yin, K. S.; Bian, T.; Sun, P. L. Imiquimod attenuates airway inflammation and decreases the expression of thymus and activation regulated chemokine in allergic asthmatic mice. Chin. Med. J. (Engl), 2006, 119, 412-416.
-
(2006)
Chin. Med. J. (Engl)
, vol.119
, pp. 412-416
-
-
Jin, S.X.1
Yin, K.S.2
Bian, T.3
Sun, P.L.4
-
37
-
-
58549116357
-
Imiquimod, a toll-like receptor 7 ligand, inhibits airway remodelling in a murine model of chronic asthma
-
Du, Q.; Zhou, L. F.; Chen, Z.; Gu, X. Y.; Huang, M.; Yin, K. S. Imiquimod, a toll-like receptor 7 ligand, inhibits airway remodelling in a murine model of chronic asthma. Clin. Exp. Pharmacol. Physiol., 2009, 36, 43-48.
-
(2009)
Clin. Exp. Pharmacol. Physiol
, vol.36
, pp. 43-48
-
-
Du, Q.1
Zhou, L.F.2
Chen, Z.3
Gu, X.Y.4
Huang, M.5
Yin, K.S.6
-
38
-
-
79952154326
-
TLR3 and TLR7 Modulate IgE Production In Antigen Induced Pulmonary Inflammation Via Influencing IL-4 Expression In Immune Organs
-
Meng, L.; He, X.; Zhu, W.; Yang, X.; Jiang, C.; Sun, Q. M. B.; Zhang, S.; Xue, Q.; Xie, X.; Lu, S. TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs. PLoS One, 2011, 6, e17252.
-
(2011)
PLoS One
, vol.6
-
-
Meng, L.1
He, X.2
Zhu, W.3
Yang, X.4
Jiang, C.5
Sun, Q.M.B.6
Zhang, S.7
Xue, Q.8
Xie, X.9
Lu, S.10
-
39
-
-
4143062435
-
Resiquimod, a new immune response modifier from the family of imidazoquinolinamines, inhibits allergen-induced Th2 responses, airway inflammation and airway hyper-reactivity in mice
-
Quarcoo, D.; Weixler, S.; Joachim, R. A.; Stock, P.; Kallinich, T.; Ahrens, B.; Hamelmann, E. Resiquimod, a new immune response modifier from the family of imidazoquinolinamines, inhibits allergen-induced Th2 responses, airway inflammation and airway hyper-reactivity in mice. Clin. Exp. Allergy, 2004, 34, 1314-1320.
-
(2004)
Clin. Exp. Allergy
, vol.34
, pp. 1314-1320
-
-
Quarcoo, D.1
Weixler, S.2
Joachim, R.A.3
Stock, P.4
Kallinich, T.5
Ahrens, B.6
Hamelmann, E.7
-
40
-
-
33646569666
-
TLR7 ligand prevents allergeninduced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway
-
Moisan, J.; Camateros, P.; Thuraisingam, T.; Marion, D.; Koohsari, H.; Martin, P.; Boghdady, M. L.; Ding, A.; Gaestel, M.; Guiot, M. C.; Martin, J. G.; Radzioch, D. TLR7 ligand prevents allergeninduced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway. Am. J. Physiol. Lung Cell. Mol. Physiol., 2006, 290, L987-95.
-
(2006)
Am. J. Physiol. Lung Cell. Mol. Physiol
, vol.290
, pp. 987-995
-
-
Moisan, J.1
Camateros, P.2
Thuraisingam, T.3
Marion, D.4
Koohsari, H.5
Martin, P.6
Boghdady, M.L.7
Ding, A.8
Gaestel, M.9
Guiot, M.C.10
Martin, J.G.11
Radzioch, D.12
-
41
-
-
34250161593
-
Chronic asthma-induced airway remodeling is prevented by toll-like receptor-7/8 ligand S28463
-
Camateros, P.; Tamaoka, M.; Hassan, M.; Marino, R.; Moisan, J.; Marion, D.; Guiot, M. C.; Martin, J. G.; Radzioch, D. Chronic asthma-induced airway remodeling is prevented by toll-like receptor-7/8 ligand S28463. Am. J. Respir. Crit. Care Med., 2007, 175, 1241-1249.
-
(2007)
Am. J. Respir. Crit. Care Med
, vol.175
, pp. 1241-1249
-
-
Camateros, P.1
Tamaoka, M.2
Hassan, M.3
Marino, R.4
Moisan, J.5
Marion, D.6
Guiot, M.C.7
Martin, J.G.8
Radzioch, D.9
-
42
-
-
34250197818
-
Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10
-
Sel, S.; Wegmann, M.; Sel, S.; Bauer, S.; Garn, H.; Alber, G.; Renz, H. Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10. J. Immunol., 2007, 178, 7805-7813.
-
(2007)
J. Immunol
, vol.178
, pp. 7805-7813
-
-
Sel, S.1
Wegmann, M.2
Sel, S.3
Bauer, S.4
Garn, H.5
Alber, G.6
Renz, H.7
-
43
-
-
68849090307
-
Modulation of the allergic asthma transcriptome following resiquimod treatment
-
Camateros, P.; Kanagaratham, C.; Henri, J.; Sladek, R.; Hudson, T. J.; Radzioch, D. Modulation of the allergic asthma transcriptome following resiquimod treatment. Physiol. Genomics, 2009, 38, 303-318.
-
(2009)
Physiol. Genomics
, vol.38
, pp. 303-318
-
-
Camateros, P.1
Kanagaratham, C.2
Henri, J.3
Sladek, R.4
Hudson, T.J.5
Radzioch, D.6
-
44
-
-
77955369313
-
Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice
-
Aumeunier, A.; Grela, F.; Ramadan, A.; Pham Van, L.; Bardel, E.; Gomez Alcala, A.; Jeannin, P.; Akira, S.; Bach, J. F.; Thieblemont, N. Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice. PLoS One, 2010, 5, e11484.
-
(2010)
PLoS One
, vol.5
-
-
Aumeunier, A.1
Grela, F.2
Ramadan, A.3
van Pham, L.4
Bardel, E.5
Gomez Alcala, A.6
Jeannin, P.7
Akira, S.8
Bach, J.F.9
Thieblemont, N.10
-
45
-
-
77954754177
-
Toll-like receptor 7- triggered immune response in the lung mediates acute and longlasting suppression of experimental asthma
-
Xirakia, C.; Koltsida, O.; Stavropoulos, A.; Thanassopoulou, A.; Aidinis, V.; Sideras, P.; Andreakos, E. Toll-like receptor 7- triggered immune response in the lung mediates acute and longlasting suppression of experimental asthma. Am. J. Respir. Crit. Care Med., 2010, 181, 1207-1216.
-
(2010)
Am. J. Respir. Crit. Care Med
, vol.181
, pp. 1207-1216
-
-
Xirakia, C.1
Koltsida, O.2
Stavropoulos, A.3
Thanassopoulou, A.4
Aidinis, V.5
Sideras, P.6
Andreakos, E.7
-
46
-
-
79951956167
-
TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways
-
Duechs, M. J.; Hahn, C.; Benediktus, E.; Werner-Klein, M.; Braun, A.; Hoymann, H. G.; Gantner, F.; Erb, K. J. TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways. Pulm. Pharmacol. Ther., 2011, 24, 203-214.
-
(2011)
Pulm. Pharmacol. Ther
, vol.24
, pp. 203-214
-
-
Duechs, M.J.1
Hahn, C.2
Benediktus, E.3
Werner-Klein, M.4
Braun, A.5
Hoymann, H.G.6
Gantner, F.7
Erb, K.J.8
-
47
-
-
79251554653
-
The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma
-
Grela, F.; Aumeunier, A.; Bardel, E.; Van, L. P.; Bourgeois, E.; Vanoirbeek, J.; Leite-de-Moraes, M.; Schneider, E.; Dy, M.; Herbelin, A.; Thieblemont, N. The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma. J. Immunol., 2011, 186, 284-290.
-
(2011)
J. Immunol
, vol.186
, pp. 284-290
-
-
Grela, F.1
Aumeunier, A.2
Bardel, E.3
Van, L.P.4
Bourgeois, E.5
Vanoirbeek, J.6
Leite-de-Moraes, M.7
Schneider, E.8
Dy, M.9
Herbelin, A.10
Thieblemont, N.11
-
48
-
-
79955011126
-
Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice
-
Marino, R.; Thuraisingam, T.; Camateros, P.; Kanagaratham, C.; Xu, Y. Z.; Henri, J.; Yang, J.; He, G.; Ding, A.; Radzioch, D. Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice. J. Immunol., 2011, 186, 4433-4442.
-
(2011)
J. Immunol
, vol.186
, pp. 4433-4442
-
-
Marino, R.1
Thuraisingam, T.2
Camateros, P.3
Kanagaratham, C.4
Xu, Y.Z.5
Henri, J.6
Yang, J.7
He, G.8
Ding, A.9
Radzioch, D.10
-
49
-
-
79959718812
-
Treatment with the TLR7 agonist R848 induces regulatory T-cell-mediated suppression of established asthma symptoms
-
Van, L. P.; Bardel, E.; Gregoire, S.; Vanoirbeek, J.; Schneider, E.; Dy, M.; Thieblemont, N. Treatment with the TLR7 agonist R848 induces regulatory T-cell-mediated suppression of established asthma symptoms. Eur. J. Immunol., 2011, 41, 1992-1999.
-
(2011)
Eur. J. Immunol
, vol.41
, pp. 1992-1999
-
-
Van, L.P.1
Bardel, E.2
Gregoire, S.3
Vanoirbeek, J.4
Schneider, E.5
Dy, M.6
Thieblemont, N.7
-
50
-
-
84859313808
-
Biological characterisation of a novel class of toll-like receptor 7 (TLR7) agonists designed to have reduced systemic activity
-
Biffen, M.; Matsui, H.; Edwards, S.; Leishman, A. J.; Eiho, K.; Holness, E.; Satterthwaite, G.; Doyle, I.; Wada, H.; Fraser, N. J.; Hawkins, S. L.; Aoki, M.; Tomizawa, H.; Benjamin, A. D.; Takaku, H.; McInally, T.; Murray, C. M. Biological characterisation of a novel class of toll-like receptor 7 (TLR7) agonists designed to have reduced systemic activity. Br. J. Pharmacol., 2012, 166, 573-586.
-
(2012)
Br. J. Pharmacol
, vol.166
, pp. 573-586
-
-
Biffen, M.1
Matsui, H.2
Edwards, S.3
Leishman, A.J.4
Eiho, K.5
Holness, E.6
Satterthwaite, G.7
Doyle, I.8
Wada, H.9
Fraser, N.J.10
Hawkins, S.L.11
Aoki, M.12
Tomizawa, H.13
Benjamin, A.D.14
Takaku, H.15
McInally, T.16
Murray, C.M.17
-
51
-
-
60549100776
-
Modified adenine (9-benzyl- 2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7
-
Vultaggio, A.; Nencini, F.; Fitch, P. M.; Fili, L.; Maggi, L.; Fanti, P.; deVries, A.; Beccastrini, E.; Palandri, F.; Manuelli, C.; Bani, D.; Giudizi, M. G.; Guarna, A.; Annunziato, F.; Romagnani, S.; Maggi, E.; Howie, S. E.; Parronchi, P. Modified adenine (9-benzyl- 2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7. J. Immunol., 2009, 182, 880-889.
-
(2009)
J. Immunol
, vol.182
, pp. 880-889
-
-
Vultaggio, A.1
Nencini, F.2
Fitch, P.M.3
Fili, L.4
Maggi, L.5
Fanti, P.6
Devries, A.7
Beccastrini, E.8
Palandri, F.9
Manuelli, C.10
Bani, D.11
Giudizi, M.G.12
Guarna, A.13
Annunziato, F.14
Romagnani, S.15
Maggi, E.16
Howie, S.E.17
Parronchi, P.18
-
52
-
-
79954996142
-
The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines
-
Vultaggio, A.; Nencini, F.; Pratesi, S.; Maggi, L.; Guarna, A.; Annunziato, F.; Romagnani, S.; Parronchi, P.; Maggi, E. The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines. J. Immunol., 2011, 186, 4707-4715.
-
(2011)
J. Immunol
, vol.186
, pp. 4707-4715
-
-
Vultaggio, A.1
Nencini, F.2
Pratesi, S.3
Maggi, L.4
Guarna, A.5
Annunziato, F.6
Romagnani, S.7
Parronchi, P.8
Maggi, E.9
-
53
-
-
33846181945
-
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats
-
Hammerbeck, D. M.; Burleson, G. R.; Schuller, C. J.; Vasilakos, J. P.; Tomai, M.; Egging, E.; Cochran, F. R.; Woulfe, S.; Miller, R. L. Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Antiviral Res., 2007, 73, 1-11.
-
(2007)
Antiviral Res
, vol.73
, pp. 1-11
-
-
Hammerbeck, D.M.1
Burleson, G.R.2
Schuller, C.J.3
Vasilakos, J.P.4
Tomai, M.5
Egging, E.6
Cochran, F.R.7
Woulfe, S.8
Miller, R.L.9
-
54
-
-
0036088492
-
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
-
Jurk, M.; Heil, F.; Vollmer, J.; Schetter, C.; Krieg, A. M.; Wagner, H.; Lipford, G.; Bauer, S. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol., 2002, 3, 499.
-
(2002)
Nat. Immunol
, vol.3
, pp. 499
-
-
Jurk, M.1
Heil, F.2
Vollmer, J.3
Schetter, C.4
Krieg, A.M.5
Wagner, H.6
Lipford, G.7
Bauer, S.8
-
55
-
-
33750823681
-
Cutting edge: Activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides
-
Gorden, K. K.; Qiu, X. X.; Binsfeld, C. C.; Vasilakos, J. P.; Alkan, S. S. Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides. J. Immunol., 2006, 177, 6584-6587.
-
(2006)
J. Immunol
, vol.177
, pp. 6584-6587
-
-
Gorden, K.K.1
Qiu, X.X.2
Binsfeld, C.C.3
Vasilakos, J.P.4
Alkan, S.S.5
-
56
-
-
21844476225
-
Alpha-Galactosylceramide, a ligand of natural killer T cells, inhibits allergic airway inflammation
-
Matsuda, H.; Suda, T.; Sato, J.; Nagata, T.; Koide, Y.; Chida, K.; Nakamura, H. Alpha-Galactosylceramide, a ligand of natural killer T cells, inhibits allergic airway inflammation. Am. J. Respir. Cell Mol. Biol., 2005, 33, 22-31.
-
(2005)
Am. J. Respir. Cell Mol. Biol
, vol.33
, pp. 22-31
-
-
Matsuda, H.1
Suda, T.2
Sato, J.3
Nagata, T.4
Koide, Y.5
Chida, K.6
Nakamura, H.7
-
57
-
-
27644586260
-
Alpha-galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice: Role of IFN-gamma
-
Hachem, P.; Lisbonne, M.; Michel, M. L.; Diem, S.; Roongapinun, S.; Lefort, J.; Marchal, G.; Herbelin, A.; Askenase, P. W.; Dy, M.; Leite-de-Moraes, M. C. Alpha-galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice: role of IFN-gamma. Eur. J. Immunol., 2005, 35, 2793-2802.
-
(2005)
Eur. J. Immunol
, vol.35
, pp. 2793-2802
-
-
Hachem, P.1
Lisbonne, M.2
Michel, M.L.3
Diem, S.4
Roongapinun, S.5
Lefort, J.6
Marchal, G.7
Herbelin, A.8
Askenase, P.W.9
Dy, M.10
Leite-de-Moraes, M.C.11
-
58
-
-
0036452588
-
Inhibition of IgE production by the imidazoquinoline resiquimod in nonallergic and allergic donors
-
Frotscher, B.; Anton, K.; Worm, M. Inhibition of IgE production by the imidazoquinoline resiquimod in nonallergic and allergic donors. J. Invest. Dermatol., 2002, 119, 1059-1064.
-
(2002)
J. Invest. Dermatol
, vol.119
, pp. 1059-1064
-
-
Frotscher, B.1
Anton, K.2
Worm, M.3
-
59
-
-
43549113087
-
TLR7/8 ligand, R-848, inhibits IgE synthesis by acting directly on B lymphocytes
-
Shen, E.; Lu, L.; Wu, C. TLR7/8 ligand, R-848, inhibits IgE synthesis by acting directly on B lymphocytes. Scand. J. Immunol., 2008, 67, 560-568.
-
(2008)
Scand. J. Immunol
, vol.67
, pp. 560-568
-
-
Shen, E.1
Lu, L.2
Wu, C.3
-
60
-
-
33746762226
-
Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release
-
Fili, L.; Ferri, S.; Guarna, F.; Sampognaro, S.; Manuelli, C.; Liotta, F.; Cosmi, L.; Matucci, A.; Vultaggio, A.; Annunziato, F.; Maggi, E.; Guarna, A.; Romagnani, S.; Parronchi, P. Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release. J. Allergy Clin. Immunol., 2006, 118, 511-517.
-
(2006)
J. Allergy Clin. Immunol
, vol.118
, pp. 511-517
-
-
Fili, L.1
Ferri, S.2
Guarna, F.3
Sampognaro, S.4
Manuelli, C.5
Liotta, F.6
Cosmi, L.7
Matucci, A.8
Vultaggio, A.9
Annunziato, F.10
Maggi, E.11
Guarna, A.12
Romagnani, S.13
Parronchi, P.14
-
61
-
-
0037323845
-
The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells
-
Brugnolo, F.; Sampognaro, S.; Liotta, F.; Cosmi, L.; Annunziato, F.; Manuelli, C.; Campi, P.; Maggi, E.; Romagnani, S.; Parronchi, P. The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells. J. Allergy Clin. Immunol., 2003, 111, 380-388.
-
(2003)
J. Allergy Clin. Immunol
, vol.111
, pp. 380-388
-
-
Brugnolo, F.1
Sampognaro, S.2
Liotta, F.3
Cosmi, L.4
Annunziato, F.5
Manuelli, C.6
Campi, P.7
Maggi, E.8
Romagnani, S.9
Parronchi, P.10
-
62
-
-
69249212244
-
Animal models of airway inflammation and airway smooth muscle remodelling in asthma
-
Allen, J. E.; Bischof, R. J.; Sucie Chang, H. Y.; Hirota, J. A.; Hirst, S. J.; Inman, M. D.; Mitzner, W.; Sutherland, T. E. Animal models of airway inflammation and airway smooth muscle remodelling in asthma. Pulm. Pharmacol. Ther., 2009, 22, 455-465.
-
(2009)
Pulm. Pharmacol. Ther
, vol.22
, pp. 455-465
-
-
Allen, J.E.1
Bischof, R.J.2
Sucie Chang, H.Y.3
Hirota, J.A.4
Hirst, S.J.5
Inman, M.D.6
Mitzner, W.7
Sutherland, T.E.8
-
63
-
-
0028804109
-
Effect of early vs late intervention with inhaled corticosteroids in asthma
-
Selroos, O.; Pietinalho, A.; Lofroos, A. B.; Riska, H. Effect of early vs late intervention with inhaled corticosteroids in asthma. Chest, 1995, 108, 1228-1234.
-
(1995)
Chest
, vol.108
, pp. 1228-1234
-
-
Selroos, O.1
Pietinalho, A.2
Lofroos, A.B.3
Riska, H.4
-
64
-
-
79551468701
-
Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs
-
Kaufman, E. H.; Fryer, A. D.; Jacoby, D. B. Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs. J. Allergy Clin. Immunol., 2011, 127, 462-469.
-
(2011)
J. Allergy Clin. Immunol
, vol.127
, pp. 462-469
-
-
Kaufman, E.H.1
Fryer, A.D.2
Jacoby, D.B.3
-
65
-
-
45149089562
-
Vaccines for preventing influenza in people with asthma
-
Cates, C. J.; Jefferson, T. O.; Rowe, B. H. Vaccines for preventing influenza in people with asthma. Cochrane Database Syst. Rev., 2008, 2, CD000364.
-
(2008)
Cochrane Database Syst. Rev
, vol.2
-
-
Cates, C.J.1
Jefferson, T.O.2
Rowe, B.H.3
-
66
-
-
47549116006
-
Vaccines: Correlates of vaccine-induced immunity
-
Plotkin, S. A. Vaccines: correlates of vaccine-induced immunity. Clin. Infect. Dis., 2008, 47, 401-409.
-
(2008)
Clin. Infect. Dis
, vol.47
, pp. 401-409
-
-
Plotkin, S.A.1
-
67
-
-
79955505656
-
Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets
-
Kastenmuller, K.; Wille-Reece, U.; Lindsay, R. W.; Trager, L. R.; Darrah, P. A.; Flynn, B. J.; Becker, M. R.; Udey, M. C.; Clausen, B. E.; Igyarto, B. Z.; Kaplan, D. H.; Kastenmuller, W.; Germain, R. N.; Seder, R. A. Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. J. Clin. Invest., 2011, 121, 1782-1796.
-
(2011)
J. Clin. Invest
, vol.121
, pp. 1782-1796
-
-
Kastenmuller, K.1
Wille-Reece, U.2
Lindsay, R.W.3
Trager, L.R.4
Darrah, P.A.5
Flynn, B.J.6
Becker, M.R.7
Udey, M.C.8
Clausen, B.E.9
Igyarto, B.Z.10
Kaplan, D.H.11
Kastenmuller, W.12
Germain, R.N.13
Seder, R.A.14
-
68
-
-
84871356814
-
-
Clinical Trials Registry, Accessed March 17, 2012
-
Clinical Trials Registry: Dendritic Cell Vaccine for Patients With Brain Tumors. http://www.clinicaltrial.gov/ct2/show/NCT01204684?term=NCT01204684&rank=1 [Accessed March 17, 2012].
-
Dendritic Cell Vaccine For Patients With Brain Tumors
-
-
-
69
-
-
0031910959
-
Attenuation of virus-induced airway dysfunction in rats treated with imiquimod
-
Stokes, J. R.; Sorkness, R. L.; Kaplan, M. R.; Castleman, W. L.; Tomai, M. A.; Miller, R. L.; Lemanske, R. F., Jr. Attenuation of virus-induced airway dysfunction in rats treated with imiquimod. Eur. Respir. J., 1998, 11, 324-329.
-
(1998)
Eur. Respir. J
, vol.11
, pp. 324-329
-
-
Stokes, J.R.1
Sorkness, R.L.2
Kaplan, M.R.3
Castleman, W.L.4
Tomai, M.A.5
Miller, R.L.6
Lemanske Jr., R.F.7
-
70
-
-
0028071434
-
Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs
-
Harrison, C. J.; Miller, R. L.; Bernstein, D. I. Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs. Antimicrob. Agents Chemother., 1994, 38, 2059-2064.
-
(1994)
Antimicrob. Agents Chemother
, vol.38
, pp. 2059-2064
-
-
Harrison, C.J.1
Miller, R.L.2
Bernstein, D.I.3
-
71
-
-
2342506498
-
Effect of interferon-alpha and interferoninducers on West Nile virus in mouse and hamster animal models
-
Morrey, J. D.; Day, C. W.; Julander, J. G.; Blatt, L. M.; Smee, D. F.; Sidwell, R. W. Effect of interferon-alpha and interferoninducers on West Nile virus in mouse and hamster animal models. Antivir. Chem. Chemother., 2004, 15, 101-109.
-
(2004)
Antivir. Chem. Chemother
, vol.15
, pp. 101-109
-
-
Morrey, J.D.1
Day, C.W.2
Julander, J.G.3
Blatt, L.M.4
Smee, D.F.5
Sidwell, R.W.6
-
72
-
-
0023885618
-
Efficacy of S26308 against guinea pig cytomegalovirus infection
-
Chen, M.; Griffith, B. P.; Lucia, H. L.; Hsiung, G. D. Efficacy of S26308 against guinea pig cytomegalovirus infection. Antimicrob. Agents Chemother., 1988, 32, 678-683.
-
(1988)
Antimicrob. Agents Chemother
, vol.32
, pp. 678-683
-
-
Chen, M.1
Griffith, B.P.2
Lucia, H.L.3
Hsiung, G.D.4
-
73
-
-
77957845606
-
TLR8 deficiency leads to autoimmunity in mice
-
Demaria, O.; Pagni, P. P.; Traub, S.; de Gassart, A.; Branzk, N.; Murphy, A. J.; Valenzuela, D. M.; Yancopoulos, G. D.; Flavell, R. A.; Alexopoulou, L. TLR8 deficiency leads to autoimmunity in mice. J. Clin. Invest., 2010, 120, 3651-3662.
-
(2010)
J. Clin. Invest
, vol.120
, pp. 3651-3662
-
-
Demaria, O.1
Pagni, P.P.2
Traub, S.3
de Gassart, A.4
Branzk, N.5
Murphy, A.J.6
Valenzuela, D.M.7
Yancopoulos, G.D.8
Flavell, R.A.9
Alexopoulou, L.10
-
74
-
-
33846000646
-
The functional effects of physical interactions among Toll-like receptors 7, 8, and 9
-
Wang, J.; Shao, Y.; Bennett, T. A.; Shankar, R. A.; Wightman, P. D.; Reddy, L. G. The functional effects of physical interactions among Toll-like receptors 7, 8, and 9. J. Biol. Chem., 2006, 281, 37427-37434.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 37427-37434
-
-
Wang, J.1
Shao, Y.2
Bennett, T.A.3
Shankar, R.A.4
Wightman, P.D.5
Reddy, L.G.6
-
75
-
-
79956306542
-
The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691)
-
Fidock, M. D.; Souberbielle, B. E.; Laxton, C.; Rawal, J.; Delpuech-Adams, O.; Corey, T. P.; Colman, P.; Kumar, V.; Cheng, J. B.; Wright, K.; Srinivasan, S.; Rana, K.; Craig, C.; Horscroft, N.; Perros, M.; Westby, M.; Webster, R.; van der Ryst, E. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin. Pharmacol. Ther., 2011, 89, 821-829.
-
(2011)
Clin. Pharmacol. Ther
, vol.89
, pp. 821-829
-
-
Fidock, M.D.1
Souberbielle, B.E.2
Laxton, C.3
Rawal, J.4
Delpuech-Adams, O.5
Corey, T.P.6
Colman, P.7
Kumar, V.8
Cheng, J.B.9
Wright, K.10
Srinivasan, S.11
Rana, K.12
Craig, C.13
Horscroft, N.14
Perros, M.15
Westby, M.16
Webster, R.17
van der Ryst, E.18
|