Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 2, 2011, Pages 462-469

  Kaufman, Elad H ^a   Fryer, Allison D ^a   Jacoby, David B ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

adenosine; asthma; bronchodilator; guinea pig; imiquimod; IRS661; large conductance, calcium activated potassium channel; nitric oxide; prostaglandins; Toll like receptor 7; virus

Indexed keywords

ACETYLCHOLINE; ADENOSINE RECEPTOR; BRONCHODILATING AGENT; CL 097; GARDIQUIMOD; IMIQUIMOD; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POLYADENYLIC ACID; POLYURIDYLIC ACID; PROSTAGLANDIN; RESIQUIMOD; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; ELECTROSTIMULATION; FEMALE; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SMOOTH MUSCLE; TRACHEA; VAGUS NERVE;

ADENOSINE; ANIMALS; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; DINOPROSTONE; FEMALE; GUINEA PIGS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; NITRIC OXIDE SYNTHASE; POLY A; POLY U; T-LYMPHOCYTES, HELPER-INDUCER; TOLL-LIKE RECEPTOR 7; TRACHEA;

EID: 79551468701     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.10.029     Document Type: Article

References (40)

1. R.L. Atmar, E. Guy, K.K. Guntupalli, J.L. Zimmerman, V.D. Bandi, and B.D. Baxter Respiratory tract viral infections in inner-city asthmatic adults Arch Intern Med 158 1998 2453 2459
2. S.L. Johnston, P.K. Pattemore, G. Sanderson, S. Smith, F. Lampe, and L. Josephs Community study of role of viral infections in exacerbations of asthma in 9-11 year old children BMJ 310 1995 1225 1229
3. T. Kawai, and S. Akira Innate immune recognition of viral infection Nat Immunol 7 2006 131 137
4. S.S. Diebold, T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA Science 303 2004 1529 1531
5. T.H. Chuang, and R.J. Ulevitch Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9 Eur Cytokine Netw 11 2000 372 378
6. I.K. Demedts, K.R. Bracke, T. Maes, G.F. Joos, and G.G. Brusselle Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms Am J Respir Cell Mol Biol 35 2006 387 393
7. A. Uehara, Y. Fujimoto, K. Fukase, and H. Takada Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines Mol Immunol 44 2007 3100 3111
8. M.B. Sukkar, S. Xie, N.M. Khorasani, O.M. Kon, R. Stanbridge, and R. Issa Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle J Allergy Clin Immunol 118 2006 641 648
9. S. Moller-Larsen, M. Nyegaard, A. Haagerup, J. Vestbo, T.A. Kruse, and A.D. Borglum Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders Thorax 63 2008 1064 1069
10. M. Roponen, S.T. Yerkovich, E. Hollams, P.D. Sly, P.G. Holt, and J.W. Upham Toll-like receptor 7 function is reduced in adolescents with asthma Eur Respir J 35 2010 64 71
11. K.C. Verhein, D.B. Jacoby, and A.D. Fryer IL-1 receptors mediate persistent, but not acute, airway hyperreactivity to ozone in guinea pigs Am J Respir Cell Mol Biol 39 2008 730 738
12. T.C. Murray, and D.B. Jacoby Viral infection increases contractile but not secretory responses to substance P in ferret trachea J Appl Physiol 72 1992 608 611
13. F.J. Barrat, T. Meeker, J. Gregorio, J.H. Chan, S. Uematsu, and S. Akira Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus J Exp Med 202 2005 1131 1139
14. A.N. Freed, S.P. Peters, and H.A. Menkes Airflow-induced bronchoconstriction: role of epithelium and eicosanoid mediators J Appl Physiol 62 1987 574 581
15. S.S. Diebold, C. Massacrier, S. Akira, C. Paturel, Y. Morel, and C. Reis e Sousa Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides Eur J Immunol 36 2006 3256 3267
16. K. Hattermann, S. Picard, M. Borgeat, P. Leclerc, M. Pouliot, and P. Borgeat The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis FASEB J 21 2007 1575 1585
17. R.W. Balzary, and T.M. Cocks Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2 J Pharmacol Exp Ther 317 2006 806 812
18. O. Scheel, M. Papavlassopoulos, R. Blunck, A. Gebert, T. Hartung, and U. Zahringer Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages Infect Immun 74 2006 4354 4356
19. A. Hammadi, C. Billard, A.M. Faussat, and J.P. Kolb Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activation Nitric Oxide 19 2008 138 145
20. G. Tumurkhuu, N. Koide, J. Dagvadorj, A.S. Noman, I.I. Khuda, and Y. Naiki B1 cells produce nitric oxide in response to a series of toll-like receptor ligands Cell Immunol 261 2009 122 127
21. S. Nakajima Analysis of K inactivation and TEA action in the supramedullary cells of puffer J Gen Physiol 49 1966 629 640
22. H.G. Knaus, O.B. McManus, S.H. Lee, W.A. Schmalhofer, M. Garcia-Calvo, and L.M. Helms Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels Biochemistry 33 1994 5819 5828
23. M.P. Schon, M. Schon, and K.N. Klotz The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion J Invest Dermatol 126 2006 1338 1347
24. S.L. Johnston, P.K. Pattemore, G. Sanderson, S. Smith, M.J. Campbell, and L.K. Josephs The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis Am J Respir Crit Care Med 154 1996 654 660
25. J. Zhu, K. Lai, R. Brownile, L.A. Babiuk, and G.K. Mutwiri Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod Mol Immunol 45 2008 3238 3243
26. D.E. Spaner, R.L. Miller, J. Mena, L. Grossman, V. Sorrenti, and Y. Shi Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimod Leuk Lymphoma 46 2005 935 939
27. K.K. Gorden, X.X. Qiu, C.C. Binsfeld, J.P. Vasilakos, and S.S. Alkan Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides J Immunol 177 2006 6584 6587
28. M. Jurk, F. Heil, J. Vollmer, C. Schetter, A.M. Krieg, and H. Wagner Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848 Nat Immunol 3 2002 499
29. F. Heil, H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, and S. Akira Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 Science 303 2004 1526 1529
30. T. Lan, E.R. Kandimalla, D. Yu, L. Bhagat, Y. Li, and D. Wang Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8 Proc Natl Acad Sci U S A 104 2007 13750 13755
31. S.W. Lee, H.Z. Wang, W. Zhao, P. Ney, P.R. Brink, and G.J. Christ Prostaglandin E1 activates the large-conductance KCa channel in human corporal smooth muscle cells Int J Impot Res 11 1999 189 199
32. F. Yamaki, M. Kaga, T. Horinouchi, H. Tanaka, K. Koike, and K. Shigenobu MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms Naunyn Schmiedebergs Arch Pharmacol 364 2001 538 550
33. P. Camateros, M. Tamaoka, M. Hassan, R. Marino, J. Moisan, and D. Marion Chronic asthma-induced airway remodeling is prevented by toll-like receptor-7/8 ligand S28463 Am J Respir Crit Care Med 175 2007 1241 1249
34. J. Moisan, P. Camateros, T. Thuraisingam, D. Marion, H. Koohsari, and P. Martin TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway Am J Physiol Lung Cell Mol Physiol 290 2006 L987 L995
35. P. Camateros, C. Kanagaratham, J. Henri, R. Sladek, T.J. Hudson, and D. Radzioch Modulation of the allergic asthma transcriptome following resiquimod treatment Physiol Genomics 38 2009 303 318
36. J.R. Stokes, R.L. Sorkness, M.R. Kaplan, W.L. Castleman, M.A. Tomai, and R.L. Miller Attenuation of virus-induced airway dysfunction in rats treated with imiquimod Eur Respir J 11 1998 324 329
37. C. Xirakia, O. Koltsida, A. Stavropoulos, A. Thanassopoulou, V. Aidinis, and P. Sideras Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma Am J Respir Crit Care Med 181 2010 1207 1216
38. M.A. Tomai, S.J. Gibson, L.M. Imbertson, R.L. Miller, P.E. Myhre, and M.J. Reiter Immunomodulating and antiviral activities of the imidazoquinoline S-28463 Antiviral Res 28 1995 253 264
39. M. Fogel, J.A. Long, P.J. Thompson, and J.W. Upham Dendritic cell maturation and IL-12 synthesis induced by the synthetic immune-response modifier S-28463 J Leukoc Biol 72 2002 932 938
40. S.T. Holgate Pathogenesis of asthma Clin Exp Allergy 38 2008 872 897