A dimerization defect caused by a glycine substitution at position 420 by serine in tissue-nonspecific alkaline phosphatase associated with perinatal hypophosphatasia

FEBS Journal

Volumn 279, Issue 23, 2012, Pages 4327-4337

  Makita, Saori ^a   Al Shawafi, Hiba A ^a   Sultana, Sara ^a   Sohda, Miwa ^a   Nomura, Shuichi ^a   Oda, Kimimitsu ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

calcification; dimerization; hypophosphatasia; inborn error of metabolism; tissue nonspecific alkaline phosphatase

Indexed keywords

ALANINE; ALKALINE PHOSPHATASE; GLYCINE; GLYCOSYLPHOSPHATIDYLINOSITOL; SERINE; TISSUE NONSPECIFIC ALKALINE PHOSPHATASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CELL STRAIN COS1; CELL SURFACE; DIMERIZATION; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME STRUCTURE; GENE EXPRESSION; GENE INTERACTION; GENE LOCATION; GENETIC TRANSFECTION; HYPOPHOSPHATASIA; IMMUNOFLUORESCENCE; LIPID BILAYER; MISSENSE MUTATION; PERINATAL HYPOPHOSPHATASIA; PERINATAL MORBIDITY; PRIORITY JOURNAL; PROTEIN SUBUNIT; TNSALP GENE; WESTERN BLOTTING; WILD TYPE;

ALKALINE PHOSPHATASE; ANIMALS; BLOTTING, WESTERN; CENTRIFUGATION, DENSITY GRADIENT; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; DIMERIZATION; GLYCINE; HUMANS; HYPOPHOSPHATASIA; MUTATION; SERINE;

EID: 84870067169     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12022     Document Type: Article

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