Tissue-nonspecific alkaline phosphatase with an Asp289→Val mutation fails to reach the cell surface and undergoes proteasome-mediated degradation

Journal of Biochemistry

Volumn 134, Issue 1, 2003, Pages 63-70

  Ishida, Yoko ^a   Komaru, Keiichi ^a,b   Ito, Masahiro ^a   Amaya, Yoshihiro ^a   Kohno, Shoji ^a   Oda, Kimimitsu ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Alkaline phosphatase; Calcium; Hypophosphatasia; Proteasome; Ubiquitination

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTIC ACID; CALCIUM ION; GLUTAMINE; GLYCINE; PROTEASOME; TISSUE NONSPECIFIC ALKALINE PHOSPHATASE; UBIQUITIN; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CALCIUM BINDING; CELL SURFACE; CONTROLLED STUDY; DISULFIDE BOND; ENZYME ACTIVITY; GENETIC TRANSFECTION; HYPOPHOSPHATASIA; NONHUMAN; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FOLDING; TRANSLATION REGULATION;

ALKALINE PHOSPHATASE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTEINE ENDOPEPTIDASES; DOGS; FLUORESCENT ANTIBODY TECHNIQUE; MICROSOMES; MULTIENZYME COMPLEXES; MUTATION, MISSENSE; PANCREAS; PRECIPITIN TESTS; PROTEIN BIOSYNTHESIS; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; TRANSFECTION; UBIQUITIN; VALINE;

ANIMALIA;

EID: 0041318958     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvg114     Document Type: Article

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