Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension: Retarded secretion and proteasomal degradation

FEBS Journal

Volumn 272, Issue 7, 2005, Pages 1704-1717

  Komaru, Keiichi ^a,b   Ishida, Yoko ^a   Amaya, Yoshihiro ^a   Goseki Sone, Masae ^c   Orimo, Hideo ^d   Oda, Kimimitsu ^a,e  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c JAPAN WOMEN'S UNIVERSITY   (Japan)

^d NIPPON MEDICAL SCHOOL   (Japan)

^e NIIGATA UNIVERSITY   (Japan)

Author keywords

Aggregation; Alkaline phosphatase; Degradation; Hypophosphatasia; Proteasome; Ubiquitin

Indexed keywords

ALKALINE PHOSPHATASE; AMINO ACID; COMPLEMENTARY DNA; CYSTEINE; MUTANT PROTEIN; PROTEASOME; SECRETORY PROTEIN; SULFUR 35; TRITON X 114;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HYPOPHOSPHATASIA; IMMUNOPRECIPITATION; ISOTOPE LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; CYSTEINE; FRAMESHIFT MUTATION; POLYETHYLENE GLYCOLS; PROTEASOME ENDOPEPTIDASE COMPLEX; SERINE; UBIQUITIN;

EID: 17144391862     PISSN: 1742464X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.04597.x     Document Type: Article

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