Aberrant interchain disulfide bridge of tissue-nonspecific alkaline phosphatase with an Arg433→Cys substitution associated with severe hypophosphatasia

FEBS Journal

Volumn 273, Issue 24, 2006, Pages 5612-5624

  Nasu, Makiko ^a   Ito, Masahiro ^a   Ishida, Yoko ^a   Numa, Natsuko ^a   Komaru, Keiichi ^b   Nomura, Shuichi ^a   Oda, Kimimitsu ^a,c  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

Author keywords

Alkaline phosphatase; Bone; Disulfide bridge; Hypophosphatasia; Loss of function

Indexed keywords

ALKALINE PHOSPHATASE; ARGININE; CYSTEINE; DITHIOTHREITOL; HISTIDINE; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BONE MINERALIZATION; CELL STRAIN COS1; CELL SURFACE; CHO CELL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS LINKING; CULTURE MEDIUM; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; HETEROLOGOUS EXPRESSION; HYPOPHOSPHATASIA; INTRACELLULAR TRANSPORT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SUCROSE DENSITY GRADIENT CENTRIFUGATION; TOOTH DEVELOPMENT; WILD TYPE;

ALKALINE PHOSPHATASE; AMINO ACID SUBSTITUTION; ANIMALS; CATALYSIS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; DISULFIDES; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HUMANS; HYPOPHOSPHATASIA; MEMBRANE PROTEINS; MUTATION; TISSUE DISTRIBUTION;

EID: 33845500975     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05550.x     Document Type: Article

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