Dose response of bone-targeted enzyme replacement for murine hypophosphatasia

Bone

Volumn 49, Issue 2, 2011, Pages 250-256

  Yadav, Manisha C ^a   Lemire, Isabelle ^b   Leonard, Pierre ^b   Boileau, Guy ^c   Blond, Laurent ^c   Beliveau, Martin ^d   Cory, Esther ^e   Sah, Robert L ^e   Whyte, Michael P ^f   Crine, Philippe ^b   Millán, José Luis ^a  

^a BURNHAM INSTITUTE   (United States)

^b Enobia Pharma   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d Pharsight   (Canada)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f WASHINGTON UNIVERSITY   (United States)

Author keywords

Alkaline phosphatase; Calcification; ENB 0040; Osteomalacia; Rickets

Indexed keywords

ASFOTASE ALFA; ENB 040; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BODY WEIGHT; BONE DEFECT; BONE MINERALIZATION; BONE RADIOGRAPHY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; ENZYME REPLACEMENT; FEMUR; FOOT; HISTOPATHOLOGY; HYPOPHOSPHATASIA; JAW; LEG; LONG BONE; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; PHENOTYPE; SURVIVAL RATE; THORAX; TIBIA;

ALKALINE PHOSPHATASE; ANIMALS; ENZYME REPLACEMENT THERAPY; HYPOPHOSPHATASIA; MICE; MICE, KNOCKOUT; OSTEOMALACIA; RECOMBINANT PROTEINS;

EID: 79958766377     PISSN: 87563282     EISSN: 87563282     Source Type: Journal    
DOI: 10.1016/j.bone.2011.03.770     Document Type: Article

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