Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia

Journal of Dental Research

Volumn 90, Issue 4, 2011, Pages 470-476

  McKee, M D ^a   Nakano, Y ^a   Masica, D L ^b   Gray, J J ^b   Lemire, I ^c   Heft, R ^c   Whyte, M P ^d   Crine, P ^c   Millan J L ^e  

^a MCGILL UNIVERSITY   (Canada)

^b Johns Hopkins University   (United States)

^c Enobia Pharma   (Canada)

^d WASHINGTON UNIVERSITY   (United States)

^e BURNHAM INSTITUTE   (United States)

Author keywords

cementum; dentin; osteopontin; tissue non specific alkaline phosphatase; tooth loss

Indexed keywords

ALKALINE PHOSPHATASE; ALKALINE PHOSPHATASE 2, MOUSE; ALPL PROTEIN, HUMAN; HYDROXYAPATITE; OSTEOPONTIN; SPP1 PROTEIN, MOUSE;

ANIMAL; BONE MINERALIZATION; CEMENTUM; CHEMISTRY; CONFERENCE PAPER; CRYSTALLOGRAPHY; DENTIN; DISEASE MODEL; DRUG EFFECT; ENZYME REPLACEMENT; GENETICS; HUMAN; HYPOPHOSPHATASIA; IMMUNOHISTOCHEMISTRY; JAW; MICRO-COMPUTED TOMOGRAPHY; MOUSE; MOUSE MUTANT; NEWBORN; PATHOLOGY; PERIODONTAL LIGAMENT; TOOTH DEVELOPMENT; TOOTH MALFORMATION; TOOTH ROOT; TOOTH SOCKET; TRANSMISSION ELECTRON MICROSCOPY;

ALKALINE PHOSPHATASE; ALVEOLAR PROCESS; ANIMALS; ANIMALS, NEWBORN; CALCIFICATION, PHYSIOLOGIC; CEMENTOGENESIS; CRYSTALLOGRAPHY; DENTAL CEMENTUM; DENTIN; DISEASE MODELS, ANIMAL; DURAPATITE; ENZYME REPLACEMENT THERAPY; HUMANS; HYPOPHOSPHATASIA; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; ODONTOGENESIS; OSTEOPONTIN; PERIODONTAL LIGAMENT; TOOTH ABNORMALITIES; TOOTH CALCIFICATION; TOOTH ROOT; TOOTH SOCKET; X-RAY MICROTOMOGRAPHY;

EID: 79954604148     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034510393517     Document Type: Conference Paper

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