Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406: Structural importance of the crown domain

FEBS Journal

Volumn 275, Issue 11, 2008, Pages 2727-2737

  Numa, Natsuko ^a   Ishida, Yoko ^a   Nasu, Makiko ^a   Sohda, Miwa ^a   Misumi, Yoshio ^b   Noda, Tadashi ^a   Oda, Kimimitsu ^a,c  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

Author keywords

Crown domain; Glycosylphosphatidylinositol; Hypophosphatasia; Raft; Tissue nonspecific alkaline phosphatase

Indexed keywords

ALANINE; ALKALINE PHOSPHATASE; DIMER; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; ISOLEUCINE; LEUCINE; MUTANT PROTEIN; PHENYLALANINE; PROTEINASE K; TISSUE NONSPECIFIC ALKALINE PHOSPHATASE; TRYPSIN; VALINE;

ALKALINE PHOSPHATASE BLOOD LEVEL; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL LINE; CHINESE HAMSTER; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ANALYSIS; ENZYME DEGRADATION; GENE EXPRESSION; GENE SYNTHESIS; GOLGI COMPLEX; HYPOPHOSPHATASIA; MUTATIONAL ANALYSIS; NONHUMAN; PERINATAL MORBIDITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PURIFICATION; SENSITIVITY ANALYSIS; SUCROSE GRADIENT; TRANSIENT EXPRESSION; WILD TYPE;

ALANINE; ALKALINE PHOSPHATASE; ANIMALS; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; HUMANS; HYPOPHOSPHATASIA; KINETICS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; VALINE;

EID: 43549100025     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06414.x     Document Type: Article

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