Bone morphogenetic protein 2 (BMP-2) induces sequential changes of Id gene expression in the breast cancer cell line MCF-7

Journal of Cancer Research and Clinical Oncology

Volumn 126, Issue 5, 2000, Pages 271-279

  Clement, Joachim H ^a   Marr, Nannette ^b,d   Meissner, Anke ^a   Schwalbe, Manuela ^a   Sebald, Walter ^c   Kliche, Kay Oliver ^a   Höffken, Klaus ^a   Wölfl, Stefan ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

Bone morphogenetic protein 2; Breast cancer; Expression array; Id proteins; Tumor biology

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COMPLEMENTARY DNA;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE; CELL STRAIN MCF 7; CONTROLLED STUDY; GENE EXPRESSION SYSTEM; HUMAN; HUMAN TISSUE; MAMMARY GLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0034100406     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050342     Document Type: Article

References (42)

1. Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H (1990) The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61: 49-59
2. Burow ME, Weldon CB, Tang Y, Navar GL, Krajewski S, Reed JC, Hammond TG, Clejan S, Beckman BS (1998) Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. Cancer Res 58: 4940-4946
3. Clement JH, Fettes P, Knöchel S, Lef J, Knöchel W (1995) Bone morphogenetic protein 2 in the early development of Xenopus laevis. Mech Dev 52: 357-370
4. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326: 1-16
5. Desprez PY, Kara E, Bissell MJ, Campisi J (1995) Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. Mol Cell Biol 15: 3398-3404
6. Desprez PY, Lin CQ, Thomasset N, Sympson CJ, Bissell MJ, Campisi J (1998) A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1. Mol Cell Biol 18: 4577-4588
7. Dickson RB, Lippman ME (1995) Growth factors in breast cancer. Endocr Rev 16: 559-589
8. Estevez M, Attisano L, Wrana JL, Albert PS, Massague J, Riddle DL (1993) The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature 365: 644-649
9. Fishell G (1999) BMPs: time to murder and create? Nat Neurosci 2: 301-303
10. Graham A, Francis-West P, Brickell P, Lumsden A (1994) The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372: 684-686
11. 1 progression and are repressed in senescent human fibroblasts. J Biol Chem 269: 2139-2145
12. Hogan BLM (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10: 1580-1594
13. Hollnagel A, Oehlmann V, Heymer J, Rüther U, Nordheim A (1999) Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 274: 19838-19845
14. Iavarone A, Garg P, Lasorella A, Hsu J, Israel MA (1994) The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev 8: 1270-1284
15. Jones CM, Lyons KM, Lapan PM, Wright CVE, Hogan BLM (1992) DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development 115: 639-647
16. Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T (1994) Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 127: 1755-1766
17. Kaufmann E, Paul H, Friedle H, Metz A, Scheucher M, Clement JH, Knöchel W (1996) Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1′ in Xenopus laevis embryos. EMBO J 15: 6739-6749
18. Lasorella A, Iavarone A, Israel MA (1996) Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol Cell Biol 16: 2570-2578
19. Le Jossic C, Ilyin GP, Loyer P, Glaise D, Cariou S, Guguen-Guillouzo C (1994) Expression of helix-loop-helix factor Id-1 is dependent on the hepatocyte proliferation and differentiation status in rat liver and in primary culture. Cancer Res 54: 6065-6068
20. Li H, Yuan J (1999) Deciphering the pathways of life and death. Curr Opin Cell Biol 11: 261-266
21. Liu F, Ventura F, Doody J, Massagué J (1995) Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol 15: 3479-3486
22. Loveys DA, Streiff MB, Kato GJ (1996) E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res 24: 2813-2820
23. Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ (1994) rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. J Biol Chem 269: 10720-10728
24. Norton JD, Atherton GT (1998) Coupling of cell growth control and apoptosis functions of Id proteins. Mol Cell Biol 18: 2371-2381
25. Norton JD, Deed RW, Craggs G, Sablitzky F (1998) Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol 8: 58-65
26. Ogata T, Wozney JM, Benezra R, Noda M (1993) Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells. Proc Natl Acad Sci USA 90: 9219-9222
27. Ohashi K, Mizuno K, Kuma K, Miyata T, Nakamura T (1994) Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain. Oncogene 9: 699-705
28. Perides G, Safran RM, Downing LA, Charness ME (1994) Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. Selective effects of the bone morphogenetic proteins. J Biol Chem 269: 765-770
29. Phippard DJ, Weber-Hall SJ, Sharpe PT, Naylor MS, Jayatalake H, Maas R, Woo I, Roberts-Clark D, Francis-West PH, Liu YH, Maxson R, Hill RE, Dale TC (1996) Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development 122: 2729-2737
30. Piscione TD, Yager TD, Gupta IR, Grinfeld B, Pei Y, Attisano L, Wrana JL, Rosenblum ND (1997) BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis. Am J Physiol 273: F961-975
31. Rosenzweig BL, Imamura T, Okadome T, Cox GN, Yamashita H, ten Dijke P, Heldin CH, Miyazono K (1995) Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci USA 92: 7632-7636
32. Ruppert R, Hoffmann E, Sebald W (1996) Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity. Eur J Biochem 237: 295-302
33. Sun XH, Copeland NG, Jenkins NA, Baltimore D (1991) Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol 11: 5603-5611
34. Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL, Buchwald M (1998) The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development 125: 1877-1887
35. Tang D, Kidd VJ (1998) Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis. J Biol Chem 273: 28549-28552
36. Urist MR (1965) Bone: formation by autoinduction. Science 150: 893-899
37. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW, Mak TW (1998) Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 12: 806-819
38. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (1988) Novel regulators of bone formation: molecular clones and activities. Science 242: 1528-1534
39. Yamamoto N, Akiyama S, Katagiri T, Namiki M, Kurokawa T, Suda T (1997) Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts. Biochem Biophys Res Commun 238: 574-580
40. Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD (1999) Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCP ETS-domain transcription factors. EMBO J 18: 968-976
41. Zhang Y, Musci T, Derynck R (1997) The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Curr Biol 7: 270-276
42. Zhu W, Dahmen J, Bulfone A, Rigolet M, Hernandez MC, Kuo WL, Puelles L, Rubenstein JL, Israel MA (1995) Id gene expression during development and molecular cloning of the human Id-1 gene. Brain Res Mol Brain Res 30: 312-326