메뉴 건너뛰기




Volumn 24, Issue 6, 2012, Pages 651-657

The pathogenesis of systemic lupus erythematosus-an update

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BELIMUMAB; GLUCOCORTICOID; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PLACEBO; RITUXIMAB; STEROID; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

EID: 84869881059     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2012.10.004     Document Type: Review
Times cited : (251)

References (81)
  • 1
    • 0035525528 scopus 로고    scopus 로고
    • From T to B and back again: positive feedback in systemic autoimmune disease
    • Shlomchik M.J., Craft J.E., Mamula M.J. From T to B and back again: positive feedback in systemic autoimmune disease. Nat Rev Immunol 2001, 1:147-153.
    • (2001) Nat Rev Immunol , vol.1 , pp. 147-153
    • Shlomchik, M.J.1    Craft, J.E.2    Mamula, M.J.3
  • 3
    • 78649830454 scopus 로고    scopus 로고
    • Genetic susceptibility to systemic lupus erythematosus in the genomic era
    • Deng Y., Tsao B.P. Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat Rev Rheumatol 2010, 6:683-692.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 683-692
    • Deng, Y.1    Tsao, B.P.2
  • 6
    • 79952465573 scopus 로고    scopus 로고
    • Dissecting the immune cell mayhem that drives lupus pathogenesis
    • Craft J.E. Dissecting the immune cell mayhem that drives lupus pathogenesis. Sci Transl Med 2011, 3:73ps79.
    • (2011) Sci Transl Med , vol.3
    • Craft, J.E.1
  • 7
    • 78650108453 scopus 로고    scopus 로고
    • Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage
    • Teichmann L.L., Ols M.L., Kashgarian M., Reizis B., Kaplan D.H., Shlomchik M.J. Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity 2010, 33:967-978.
    • (2010) Immunity , vol.33 , pp. 967-978
    • Teichmann, L.L.1    Ols, M.L.2    Kashgarian, M.3    Reizis, B.4    Kaplan, D.H.5    Shlomchik, M.J.6
  • 8
    • 0037144519 scopus 로고    scopus 로고
    • Evolution of autoantibody responses via somatic hypermutation outside of germinal centers
    • William J., Euler C., Christensen S., Shlomchik M.J. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 2002, 297:2066-2070.
    • (2002) Science , vol.297 , pp. 2066-2070
    • William, J.1    Euler, C.2    Christensen, S.3    Shlomchik, M.J.4
  • 11
    • 48749085121 scopus 로고    scopus 로고
    • T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells
    • Herlands R.A., Christensen S.R., Sweet R.A., Hershberg U., Shlomchik M.J. T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity 2008, 29:249-260.
    • (2008) Immunity , vol.29 , pp. 249-260
    • Herlands, R.A.1    Christensen, S.R.2    Sweet, R.A.3    Hershberg, U.4    Shlomchik, M.J.5
  • 12
    • 79951784900 scopus 로고    scopus 로고
    • Plasma cells in systemic lupus erythematosus: the long and short of it all
    • Liu Z., Zou Y., Davidson A. Plasma cells in systemic lupus erythematosus: the long and short of it all. Eur J Immunol 2011, 41:588-591.
    • (2011) Eur J Immunol , vol.41 , pp. 588-591
    • Liu, Z.1    Zou, Y.2    Davidson, A.3
  • 13
    • 79951804160 scopus 로고    scopus 로고
    • Interferon-alpha induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZBxNZW)F1 mice but not in BALB/c mice
    • Mathian A., Gallegos M., Pascual V., Banchereau J., Koutouzov S. Interferon-alpha induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZBxNZW)F1 mice but not in BALB/c mice. Eur J Immunol 2011, 41:863-872.
    • (2011) Eur J Immunol , vol.41 , pp. 863-872
    • Mathian, A.1    Gallegos, M.2    Pascual, V.3    Banchereau, J.4    Koutouzov, S.5
  • 14
    • 37849035658 scopus 로고    scopus 로고
    • Sites and stages of autoreactive B cell activation and regulation
    • Shlomchik M.J. Sites and stages of autoreactive B cell activation and regulation. Immunity 2008, 28:18-28.
    • (2008) Immunity , vol.28 , pp. 18-28
    • Shlomchik, M.J.1
  • 15
    • 33745133006 scopus 로고    scopus 로고
    • Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells
    • Qi H., Egen J.G., Huang A.Y., Germain R.N. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 2006, 312:1672-1676.
    • (2006) Science , vol.312 , pp. 1672-1676
    • Qi, H.1    Egen, J.G.2    Huang, A.Y.3    Germain, R.N.4
  • 16
    • 84868337977 scopus 로고    scopus 로고
    • Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses
    • Chappell C.P., Draves K.E., Giltiay N.V., Clark E.A. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 2012, 209:1825-1840.
    • (2012) J Exp Med , vol.209 , pp. 1825-1840
    • Chappell, C.P.1    Draves, K.E.2    Giltiay, N.V.3    Clark, E.A.4
  • 17
    • 0035900481 scopus 로고    scopus 로고
    • Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus
    • Blanco P., Palucka A.K., Gill M., Pascual V., Banchereau J. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 2001, 294:1540-1543.
    • (2001) Science , vol.294 , pp. 1540-1543
    • Blanco, P.1    Palucka, A.K.2    Gill, M.3    Pascual, V.4    Banchereau, J.5
  • 18
    • 0036927108 scopus 로고    scopus 로고
    • The natural interferon-alpha producing cells in systemic lupus erythematosus
    • Ronnblom L., Alm G.V. The natural interferon-alpha producing cells in systemic lupus erythematosus. Hum Immunol 2002, 63:1181-1193.
    • (2002) Hum Immunol , vol.63 , pp. 1181-1193
    • Ronnblom, L.1    Alm, G.V.2
  • 20
    • 84863115400 scopus 로고    scopus 로고
    • IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus
    • Niewold T.B., Kelly J.A., Kariuki S.N., Franek B.S., Kumar A.A., Kaufman K.M., Thomas K., Walker D., Kamp S., Frost J.M., et al. IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis 2012, 71:463-468.
    • (2012) Ann Rheum Dis , vol.71 , pp. 463-468
    • Niewold, T.B.1    Kelly, J.A.2    Kariuki, S.N.3    Franek, B.S.4    Kumar, A.A.5    Kaufman, K.M.6    Thomas, K.7    Walker, D.8    Kamp, S.9    Frost, J.M.10
  • 21
    • 83455169554 scopus 로고    scopus 로고
    • Interferon alpha as a primary pathogenic factor in human lupus
    • Niewold T.B. Interferon alpha as a primary pathogenic factor in human lupus. J Interferon Cytokine Res 2011, 31:887-892.
    • (2011) J Interferon Cytokine Res , vol.31 , pp. 887-892
    • Niewold, T.B.1
  • 22
    • 84856463818 scopus 로고    scopus 로고
    • Treatment of systemic lupus erythematosus: new advances in targeted therapy
    • Lo M.S., Tsokos G.C. Treatment of systemic lupus erythematosus: new advances in targeted therapy. Ann N Y Acad Sci 2012, 1247:138-152.
    • (2012) Ann N Y Acad Sci , vol.1247 , pp. 138-152
    • Lo, M.S.1    Tsokos, G.C.2
  • 23
    • 80053562466 scopus 로고    scopus 로고
    • Safety profile and clinical activity of sifalimumab, a fully human anti-interferon alpha monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study
    • Merrill J.T., Wallace D.J., Petri M., Kirou K.A., Yao Y., White W.I., Robbie G., Levin R., Berney S.M., Chindalore V., et al. Safety profile and clinical activity of sifalimumab, a fully human anti-interferon alpha monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis 2011, 70:1905-1913.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1905-1913
    • Merrill, J.T.1    Wallace, D.J.2    Petri, M.3    Kirou, K.A.4    Yao, Y.5    White, W.I.6    Robbie, G.7    Levin, R.8    Berney, S.M.9    Chindalore, V.10
  • 24
    • 84868144947 scopus 로고    scopus 로고
    • doi:10.1002/art.34632 Safety and pharmacodynamic results of rontalizumab in a phase i, placebo controlled, double blind, dose escalation study in systemic lupus erythematosus. Arthritis Rheum 2012 Jul 25. [Epub ahead of print].
    • McBride JM, Jiang J, Abbas AR, Morimoto A, Li J, Maciuca R, Townsend M, Wallace DJ, Kennedy WP, Drappa J: Safety and pharmacodynamic results of rontalizumab in a phase i, placebo controlled, double blind, dose escalation study in systemic lupus erythematosus. Arthritis Rheum 2012 Jul 25. [Epub ahead of print]. doi:10.1002/art.34632.
    • McBride, J.M.1    Jiang, J.2    Abbas, A.R.3    Morimoto, A.4    Li, J.5    Maciuca, R.6    Townsend, M.7    Wallace, D.J.8    Kennedy, W.P.9    Drappa, J.10
  • 25
    • 79955863984 scopus 로고    scopus 로고
    • Active immunisation of human interferon alpha transgenic mice with a human interferon alpha Kinoid induces antibodies that neutralise interferon alpha in sera from patients with systemic lupus erythematosus
    • Mathian A., Amoura Z., Adam E., Colaone F., Hoekman M.F., Dhellin O., Vandepapeliere P., Haroche J., Piette J.C., Lebon P., et al. Active immunisation of human interferon alpha transgenic mice with a human interferon alpha Kinoid induces antibodies that neutralise interferon alpha in sera from patients with systemic lupus erythematosus. Ann Rheum Dis 2011, 70:1138-1143.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1138-1143
    • Mathian, A.1    Amoura, Z.2    Adam, E.3    Colaone, F.4    Hoekman, M.F.5    Dhellin, O.6    Vandepapeliere, P.7    Haroche, J.8    Piette, J.C.9    Lebon, P.10
  • 26
    • 82955233986 scopus 로고    scopus 로고
    • Neutrophils in the pathogenesis and manifestations of SLE
    • Kaplan M.J. Neutrophils in the pathogenesis and manifestations of SLE. Nat Rev Rheumatol 2011, 7:691-699.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 691-699
    • Kaplan, M.J.1
  • 31
    • 47249092785 scopus 로고    scopus 로고
    • Development of TLR inhibitors for the treatment of autoimmune diseases
    • Barrat F.J., Coffman R.L. Development of TLR inhibitors for the treatment of autoimmune diseases. Immunol Rev 2008, 223:271-283.
    • (2008) Immunol Rev , vol.223 , pp. 271-283
    • Barrat, F.J.1    Coffman, R.L.2
  • 32
    • 0041324898 scopus 로고    scopus 로고
    • The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression
    • De Bosscher K., Vanden Berghe W., Haegeman G. The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev 2003, 24:488-522.
    • (2003) Endocr Rev , vol.24 , pp. 488-522
    • De Bosscher, K.1    Vanden Berghe, W.2    Haegeman, G.3
  • 34
    • 0032769336 scopus 로고    scopus 로고
    • The central and multiple roles of B cells in lupus pathogenesis
    • Chan O.T., Madaio M.P., Shlomchik M.J. The central and multiple roles of B cells in lupus pathogenesis. Immunol Rev 1999, 169:107-121.
    • (1999) Immunol Rev , vol.169 , pp. 107-121
    • Chan, O.T.1    Madaio, M.P.2    Shlomchik, M.J.3
  • 36
    • 84864885318 scopus 로고    scopus 로고
    • Updates on B-cell immunotherapies for systemic lupus erythematosus and Sjogren's syndrome
    • Coca A., Sanz I. Updates on B-cell immunotherapies for systemic lupus erythematosus and Sjogren's syndrome. Curr Opin Rheumatol 2012, 24:451-456.
    • (2012) Curr Opin Rheumatol , vol.24 , pp. 451-456
    • Coca, A.1    Sanz, I.2
  • 38
  • 40
    • 58149214308 scopus 로고    scopus 로고
    • Altered B Cell receptor signaling in human systemic lupus erythematosus
    • Jenks S.A., Sanz I: Altered B cell receptor signaling in human systemic lupus erythematosus. Autoimmun Rev 2009, 8:209-213.
    • (2009) Autoimmun Rev , vol.8 , pp. 209-213
    • Jenks, S.A.1    Sanz, I.2
  • 41
    • 21844438276 scopus 로고    scopus 로고
    • A Toll for lupus
    • Anders H.J. A Toll for lupus. Lupus 2005, 14:417-422.
    • (2005) Lupus , vol.14 , pp. 417-422
    • Anders, H.J.1
  • 42
    • 79960918034 scopus 로고    scopus 로고
    • BAFF and selection of autoreactive B cells
    • Liu Z., Davidson A. BAFF and selection of autoreactive B cells. Trends Immunol 2011, 32:388-394.
    • (2011) Trends Immunol , vol.32 , pp. 388-394
    • Liu, Z.1    Davidson, A.2
  • 43
    • 80053286823 scopus 로고    scopus 로고
    • Abnormalities of T cell signaling in systemic lupus erythematosus
    • Moulton V.R., Tsokos G.C. Abnormalities of T cell signaling in systemic lupus erythematosus. Arthritis Res Ther 2011, 13:207.
    • (2011) Arthritis Res Ther , vol.13 , pp. 207
    • Moulton, V.R.1    Tsokos, G.C.2
  • 45
    • 0023462643 scopus 로고
    • Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse
    • Shlomchik M.J., Aucoin A.H., Pisetsky D.S., Weigert M.G. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci USA 1987, 84:9150-9154.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9150-9154
    • Shlomchik, M.J.1    Aucoin, A.H.2    Pisetsky, D.S.3    Weigert, M.G.4
  • 47
    • 0345824714 scopus 로고    scopus 로고
    • Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
    • Grammer A.C., Slota R., Fischer R., Gur H., Girschick H., Yarboro C., Illei G.G., Lipsky P.E. Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions. J Clin Invest 2003, 112:1506-1520.
    • (2003) J Clin Invest , vol.112 , pp. 1506-1520
    • Grammer, A.C.1    Slota, R.2    Fischer, R.3    Gur, H.4    Girschick, H.5    Yarboro, C.6    Illei, G.G.7    Lipsky, P.E.8
  • 50
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011, 29:621-663.
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 54
    • 18944398750 scopus 로고    scopus 로고
    • Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center
    • William J., Euler C., Shlomchik M.J. Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center. J Immunol 2005, 174:6879-6887.
    • (2005) J Immunol , vol.174 , pp. 6879-6887
    • William, J.1    Euler, C.2    Shlomchik, M.J.3
  • 55
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • Simpson N., Gatenby P.A., Wilson A., Malik S., Fulcher D.A., Tangye S.G., Manku H., Vyse T.J., Roncador G., Huttley G.A., et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 2010, 62:234-244.
    • (2010) Arthritis Rheum , vol.62 , pp. 234-244
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3    Malik, S.4    Fulcher, D.A.5    Tangye, S.G.6    Manku, H.7    Vyse, T.J.8    Roncador, G.9    Huttley, G.A.10
  • 57
    • 79251521021 scopus 로고    scopus 로고
    • Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • Morita R., Schmitt N., Bentebibel S.E., Ranganathan R., Bourdery L., Zurawski G., Foucat E., Dullaers M., Oh S., Sabzghabaei N., et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011, 34:108-121.
    • (2011) Immunity , vol.34 , pp. 108-121
    • Morita, R.1    Schmitt, N.2    Bentebibel, S.E.3    Ranganathan, R.4    Bourdery, L.5    Zurawski, G.6    Foucat, E.7    Dullaers, M.8    Oh, S.9    Sabzghabaei, N.10
  • 58
    • 1242307814 scopus 로고    scopus 로고
    • B cell abnormalities in systemic lupus erythematosus
    • Grammer A.C., Lipsky P.E. B cell abnormalities in systemic lupus erythematosus. Arthritis Res Ther 2003, 5(Suppl 4):S22-S27.
    • (2003) Arthritis Res Ther , vol.5 , Issue.SUPPL 4
    • Grammer, A.C.1    Lipsky, P.E.2
  • 61
    • 72949104221 scopus 로고    scopus 로고
    • Dysregulation of germinal centres in autoimmune disease
    • Vinuesa C.G., Sanz I., Cook M.C. Dysregulation of germinal centres in autoimmune disease. Nat Rev Immunol 2009, 9:845-857.
    • (2009) Nat Rev Immunol , vol.9 , pp. 845-857
    • Vinuesa, C.G.1    Sanz, I.2    Cook, M.C.3
  • 62
    • 0037868032 scopus 로고    scopus 로고
    • Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition
    • Schiffer L., Sinha J., Wang X., Huang W., von Gersdorff G., Schiffer M., Madaio M.P., Davidson A. Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition. J Immunol 2003, 171:489-497.
    • (2003) J Immunol , vol.171 , pp. 489-497
    • Schiffer, L.1    Sinha, J.2    Wang, X.3    Huang, W.4    von Gersdorff, G.5    Schiffer, M.6    Madaio, M.P.7    Davidson, A.8
  • 63
    • 2542505506 scopus 로고    scopus 로고
    • The role of complement in the development of systemic lupus erythematosus
    • Manderson A.P., Botto M., Walport M.J. The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol 2004, 22:431-456.
    • (2004) Annu Rev Immunol , vol.22 , pp. 431-456
    • Manderson, A.P.1    Botto, M.2    Walport, M.J.3
  • 64
    • 33750837175 scopus 로고    scopus 로고
    • FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis
    • Bergtold A., Gavhane A., D'Agati V., Madaio M., Clynes R. FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis. J Immunol 2006, 177:7287-7295.
    • (2006) J Immunol , vol.177 , pp. 7287-7295
    • Bergtold, A.1    Gavhane, A.2    D'Agati, V.3    Madaio, M.4    Clynes, R.5
  • 67
    • 3242805826 scopus 로고    scopus 로고
    • Type I IFN protects against murine lupus
    • Hron J.D., Peng S.L. Type I IFN protects against murine lupus. J Immunol 2004, 173:2134-2142.
    • (2004) J Immunol , vol.173 , pp. 2134-2142
    • Hron, J.D.1    Peng, S.L.2
  • 69
    • 77953212872 scopus 로고    scopus 로고
    • Basophils and the T helper 2 environment can promote the development of lupus nephritis
    • Charles N., Hardwick D., Daugas E., Illei G.G., Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med 2010, 16:701-707.
    • (2010) Nat Med , vol.16 , pp. 701-707
    • Charles, N.1    Hardwick, D.2    Daugas, E.3    Illei, G.G.4    Rivera, J.5
  • 70
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • Chan O.T., Hannum L.G., Haberman A.M., Madaio M.P., Shlomchik M.J. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 1999, 189:1639-1648.
    • (1999) J Exp Med , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3    Madaio, M.P.4    Shlomchik, M.J.5
  • 73
    • 80053527529 scopus 로고    scopus 로고
    • An acquired defect in IgG-dependent phagocytosis explains the impairment in antibody-mediated cellular depletion in lupus
    • Ahuja A., Teichmann L.L., Wang H., Dunn R., Kehry M.R., Shlomchik M.J. An acquired defect in IgG-dependent phagocytosis explains the impairment in antibody-mediated cellular depletion in lupus. J Immunol 2011, 187:3888-3894.
    • (2011) J Immunol , vol.187 , pp. 3888-3894
    • Ahuja, A.1    Teichmann, L.L.2    Wang, H.3    Dunn, R.4    Kehry, M.R.5    Shlomchik, M.J.6
  • 75
    • 74849131972 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial
    • Merrill J.T., Neuwelt C.M., Wallace D.J., Shanahan J.C., Latinis K.M., Oates J.C., Utset T.O., Gordon C., Isenberg D.A., Hsieh H.J., et al. Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum 2010, 62:222-233.
    • (2010) Arthritis Rheum , vol.62 , pp. 222-233
    • Merrill, J.T.1    Neuwelt, C.M.2    Wallace, D.J.3    Shanahan, J.C.4    Latinis, K.M.5    Oates, J.C.6    Utset, T.O.7    Gordon, C.8    Isenberg, D.A.9    Hsieh, H.J.10
  • 78
    • 70350520105 scopus 로고    scopus 로고
    • B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels
    • Collins C.E., Gavin A.L., Migone T.S., Hilbert D.M., Nemazee D., Stohl W. B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels. Arthritis Res Ther 2006, 8:R6.
    • (2006) Arthritis Res Ther , vol.8
    • Collins, C.E.1    Gavin, A.L.2    Migone, T.S.3    Hilbert, D.M.4    Nemazee, D.5    Stohl, W.6
  • 79
    • 74849122596 scopus 로고    scopus 로고
    • Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study
    • Jacobi A.M., Huang W., Wang T., Freimuth W., Sanz I., Furie R., Mackay M., Aranow C., Diamond B., Davidson A. Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study. Arthritis Rheum 2010, 62:201-210.
    • (2010) Arthritis Rheum , vol.62 , pp. 201-210
    • Jacobi, A.M.1    Huang, W.2    Wang, T.3    Freimuth, W.4    Sanz, I.5    Furie, R.6    Mackay, M.7    Aranow, C.8    Diamond, B.9    Davidson, A.10
  • 80
    • 79952070370 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
    • Navarra S.V., Guzman R.M., Gallacher A.E., Hall S., Levy R.A., Jimenez R.E., Li E.K., Thomas M., Kim H.Y., Leon M.G., et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 2011, 377:721-731.
    • (2011) Lancet , vol.377 , pp. 721-731
    • Navarra, S.V.1    Guzman, R.M.2    Gallacher, A.E.3    Hall, S.4    Levy, R.A.5    Jimenez, R.E.6    Li, E.K.7    Thomas, M.8    Kim, H.Y.9    Leon, M.G.10
  • 81
    • 82455198794 scopus 로고    scopus 로고
    • A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus
    • Furie R., Petri M., Zamani O., Cervera R., Wallace D.J., Tegzova D., Sanchez-Guerrero J., Schwarting A., Merrill J.T., Chatham W.W., et al. A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus. Arthritis Rheum 2011, 63:3918-3930.
    • (2011) Arthritis Rheum , vol.63 , pp. 3918-3930
    • Furie, R.1    Petri, M.2    Zamani, O.3    Cervera, R.4    Wallace, D.J.5    Tegzova, D.6    Sanchez-Guerrero, J.7    Schwarting, A.8    Merrill, J.T.9    Chatham, W.W.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.