B cell abnormalities in systemic lupus erythematosus

Arthritis Research and Therapy

Volumn 5, Issue SUPPL. 4, 2003, Pages

  Grammer, Amrie C ^a   Lipsky, Peter E ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

B cells; Germinal centers; Immunoglobulin secreting cells; Plasma cells; Systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; APOPTOSIS; AUTOIMMUNE DISEASE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL DIFFERENTIATION; CELL MATURATION; CELL MEMBRANE; CELL SECRETION; CELL SURVIVAL; CHRONIC DISEASE; CLEARANCE; CYTOKINE RELEASE; GENE FUNCTION; GENE LOCUS; GENETIC SUSCEPTIBILITY; GERMINAL CENTER; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE PROLIFERATION; MOLECULAR INTERACTION; PATHOGENESIS; PHAGOCYTE; PLASMA CELL; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD40; B-CELL ACTIVATING FACTOR; B-CELL ACTIVATION FACTOR RECEPTOR; B-LYMPHOCYTES; CD40 LIGAND; HUMANS; IMMUNOGLOBULINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MEMBRANE PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 1242307814     PISSN: 14786354     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (59)

1. Grammer AC, Dorner T, Lipsky PE: Abnormalities in B cell activity and the immunoglobulin repertoire in human systemic lupus erythematosus. Mol Pathol Autoimmune Dis 2001, 2: 282-318.
2. Davidson A, Diamond B: Autoimmune diseases. N Engl J Med 2001, 345:340-350.
3. Lipsky PE: Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat Immunol 2001, 2:764-766.
4. Wakeland EK, Liu K, Graham RR, Behrens TW: Delineating the genetic basis of systemic lupus erythematosus. Immunity 2001, 15:397-408.
5. Grammer AC, Lipsky PE: CD40-mediated regulation of immune responses by TRAF-dependent and TRAF-independent signaling mechanisms. Adv Immunol 2000, 76:61-178.
6. Grammer AC, Bergman MC, Miura. Y, Fujita K, Davis LS, Lipsky PE: The CD40 ligand expressed by human B cells costimulates B cell responses. J Immunol 1995, 154:4996-5010.
7. Grammer AC, McFarland RD, Heaney J, Darnell BF, Lipsky PE: Expression, regulation, and function of B cell-expressed CD154 in germinal centers. J Immunol 1999, 163:4150-4159.
8. Grammer AC, Slota R, Fischer R, Gur H, Girschick H, Yarboro C, Illei GG, Lipsky PE. Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions. J Clin Invest 2003, 112:1506-1520.
9. Schiemann B, Gommerman JL, Vora K, Cachero TG, Shulga-Morskaya S, Dobles M, Frew E, Scott ML: An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001, 293:2111-2114.
10. Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C: BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 2001, 293:2108-2111.
11. Avery DT, Kalled SL, Ellyard JI, Ambrose C, Bixler SA, Thien M, Brink R, Mackay F, Hodgkin PD, Tangye SG: BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J Clin Invest 2003, 112:286-297.
12. von Bulow GU, van Deursen JM, Bram RJ: Regulation of the T-independent humoral response by TACI. Immunity 2001, 14: 573-582.
13. Yan M, Wang H, Chan B, Roose-Girma M, Erickson S, Baker T, Tumas D, Grewal IS, Dixit VM: Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol 2001, 2:638-643.
14. Stein JV, Lopez-Fraga M, Elustondo FA, Carvalho-Pinto CE, Rodriguez D, Gomez-Caro R, De Jong J, Martinez-A C, Medema JP, Hahne M: APRIL modulates B and T cell immunity. J Clin Invest 2002, 109:1587-1598.
15. Balazs M, Martin F, Zhou T, Kearney J: Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 2002, 17:341-352.
16. Balazs M, Martin F, Zhou T, Kearney J: Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 2002, 17:341-352.
17. Moser KL, Neas BR, Salmon JE, Yu H, Gray-McGuire C, Asundi N, Bruner GR, Fox J, Kelly J, Henshall S, Bacino D, Dietz M, Hogue R, Koelsch G, Nightingale L, Shaver T, Abdou NI, Albert DA, Carson C, Petri M, Treadwell, EL, James JA, Harley JB: Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci USA 1998, 95:14869-14874.
18. Cheema GS, Roschke V, Hilbert DM, Stohl W: Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum 2001, 44: 1313-1319.
19. Zhang J, Roschke V, Baker KP, Wang Z, Alarcon GS, Fessler BJ, Bastian H, Kimberly RP, Zhou T: Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J Immunol 2001, 166:6-10.
20. Dorner T, Lipsky PE: Immunoglobulin variable-region gene usage in systemic autoimmune diseases. Arthritis Rheum 2001, 44:2715-2727.
21. Grammer AC, McFarland RD, Heaney J, Darnell BF, Lipsky PE: Expression, regulation, and function of B cell-expressed CD154 in germinal centers. J Immunol 1999, 163:4150-4159.
22. Yavuz S, Grammer AC, Yavuz AS, Nanki T, Lipsky PE: Comparative characteristics of mu chain and alpha chain transcripts expressed by individual tonsil plasma cells. Mol Immunol 2001, 38:19-34.
23. Calame KL: Plasma cells: finding new light at the end of B cell development. Nat Immunol 2001, 2:1103-1108.
24. Ginsburg WW, Finkelman FD, Lipsky PE: Circulating and mitogen-induced immunoglobulin-secreting cells in human peripheral blood: evaluation by a modified reverse hemolytic plaque assay. J Immunol 1978, 120:33-39.
25. Jelinek DF, Lipsky PE: The role of B cell proliferation in the generation of immunoglobulin-secreting cells in man. J Immunol 1983, 130:2597-2604.
26. Vernino L, McAnally LM, Ramberg J, Lipsky PE: Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated anti-CD3-activated T cells. J Immunol 1992, 148:404-410.
27. McCarty GA, Rice JR, Bembe ML, Pisetsky DS: Independent expression of autoantibodies in systemic lupus erythematosus. J Rheumatol 1982, 9:691-695.
28. Perez MC, Wilson WA, Scopelitis E: Cyclophosphamide use in a young woman with antiphospholipid antibodies and recurrent cerebrovascular accident South Med J 1989, 82:1421-1424.
29. Thiel A, Rosen O, Massenkeil G, Gromnica E, Ihle G, Burmeister GR, Arnold R, Radbruch A, Hiepe F: Systemic immune activation and generation of new autoAb are features of a SLE flare after remission induced by autologous stem cell transplantation. Arthritis Rheum 2001, 44:S282.
30. G Cassese, Lindenau S, de Boer B, Arce S, Hauser A, Riemekasten G, Berek C, Hiepe F, Krenn V, Radbruch A, Manz RA: Inflamed kidneys of NZB/W mice are a major site for the homeostasis of plasma cells. Eur J Immunol 2001, 31:2726-2732.
31. McCune WJ, Golbus J, Zeldes W, Bohlke P, Dunne R, Fox DA: Clinical and immunologic effects of monthly administration of intravenous cyclophosphamide in severe systemic lupus erythematosus. N Engl J Med 1988, 318:1423-1431.
32. Khare SD, Sarosi I, Xia XZ, McCabe S, Miner K, Solovyev I, Hawkins N, Kelley M, Chang D, Van G, Ross L, Delaney J, Wang L, Lacey D, Boyle WJ, Hsu H: Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc Natl Acad Sci USA. 2000, 97:3370-3375.
33. Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu W, Parrish-Novak J, Foster D, Lofton-Day C, Moore M, Littau A, Grossman A, Haugen H, Foley K, Blumberg H, Harrison K, Kindsvogel W, Clegg CH: TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 2000, 404:995-999.
34. Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider P, Tschopp J, Browning JL: Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999, 190:1697-1710.
35. Do RK, Hatada E, Lee H, Tourigny MR, Hilbert D, Chen-Kiang S: Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. J Exp Med 2000, 192:953-964.
36. Lentz VM, Cancro MP, Nashold FE, Hayes CE: Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse. J Immunol 1996, 157:598-606.
37. von Bulow GU, van Deursen JM, Bram RJ: Regulation of the T-independent humoral response by TACI. Immunity 2001, 14: 573-582.
38. Yan M, Wang H, Chan B, Roose-Girma M, Erickson S, Baker T, Tumas D, Grewal IS, Dixit VM: Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol 2001, 2:638-43.
39. Stein JV, Lopez-Fraga M, Elustondo FA, Carvalho-Pinto CE, Rodriguez D, Gomez-Caro R, De Jong J, Martinez-A C, Medema JP, Hahne M: APRIL modulates B and T cell immunity. J Clin Invest 2002, 109:1587-1598.
40. Ferrari S, Giliani S, Insalaco A, Al-Ghonaium A, Soresina AR, Loubser M, Avanzini MA, Marconi M, Badolato R, Ugazio AG, Levy Y, Catalan N, Durandy A, Tbakhi A, Notarangelo LD, Plebani A: Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci USA 2001, 98:12614-12619.
41. Han S, Hathcock K, Zheng B, Kepler TB, Hodes R, Kelsoe G: Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J Immunol 1995, 155:556-567.
42. Luzina IG, Atamas AP, Storrer CE, daSilva LC, Kelsoe G, Papadimitriou JC, Handwerger BS: Spontaneous formation of germinal centers in autoimmune mice. J Leukoc Biol 2001, 70: 578-584.
43. Boumpas DT, Furie R, Manzi S, Illei GG, Wallace DJ, Balow JE, Vaishnaw A: A short course of BG9588 (Anti-CD40L Antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum 2003, 48:719-727.
44. Huang W, Sinha J, Newman J, Reddy B, Budhai L, Furie R, Vaishnaw A, Davidson A: The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus. Arthritis Rheum 2002, 46:1554-1562.
45. Mohan C, Shi Y, Laman JD, Datta SK: Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J Immunol 1995, 154:1470-1480.
46. Devi BS, van Noordin S, Krausz T, Davies KA: Peripheral blood lymphocytes in SLE - hyperexpression of CD154 on T and B lymphocytes and increased number of double negative T cells. J Autoimmunity 1998, 11:471-475.
47. + T lymphocytes with constitutive CD40 ligand in preautoimmune (NZ13 × NZW)F1 lupus-prone mice: phenotype and possible role in autoreactivity. J Immunol 2000, 165:4095-4104.
48. Poudrier J, Weng X, Kay DG, Pare G, Calvo EL, Hanna Z, Kosco-Vilbois MH, Jolicoeur P: The AIDS disease of CD4C/HIV transgenic mice shows impaired germinal centers and autoantibodies and develops in the absence of IFN-gamma and IL-6. Immunity 2001, 15:173-185.
49. Higuchi T, Aiba Y, Nomura T, Matsuda J, Mochida K, Suzuki M, Kikutani H, Honjo T, Nishioka K, Tsubata T: Cutting edge: ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol 2002, 168:9-12.
50. Weyand CM, Kurtin PJ, Goronzy JJ: Ectopic lymphoid organogenesis: a fast track for autoimmunity. Am J Pathol 2001, 159: 787-793.
51. van Nierop K, de Groot C: Human follicular dendritic cells; function, origin and development. Semin Immunol 2002, 14: 251-257.
52. de Boer BA, Voigt I, Kim HJ, Camacho SA, Lipp M, Forster R, Berek C: Affinity maturation in ectopic germinal centers. Curr Top Microbiol Immunol 2000, 251:191-195.
53. Fu YX, Storb U: Immunology. Autoreactive B cells migrate into T cell territory. Science 2002, 297:2006-2008.
54. Mandik-Nayak L, Bui A, Noorchashm H, Eaton A, Erikson J: Regulation of anti-double- stranded DNA B cells in non-autoimmune mice: localization to the T-B interface of splenic follicle. J Exp Med 1997, 186:1257-1267.
55. Wellmann U, Werner A, Winkler TH: Altered selection processes of B lymphocytes in autoimmune NZB/W mice, despite intact central tolerance against DNA. Eur J Immunol 2001, 31:2800-2810.
56. Jacobson BA, Rothstein TL, Marshak-Rothstein A: Unique site of IgG2a and rheumatoid factor production in MRL/Ipr mice. Immunol Rev 1997, 156:103-110.
57. Feuerstein N, Chen F, Madaio M, Maldonado M, Eisenberg RA: Induction of autoimmunity in a transgenic model of B cell receptor peripheral tolerance: changes in coreceptors and B cell receptor-induced tyrosine-phosphoproteins. J Immunol 1999, 163:5287-5297.
58. Eris JM, Basten A, Brink R, Doherty K, Kehry MR, Hodgkin PD: Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions. Proc Natl Acad Sci USA 1994, 91:4392-4396.
59. Cooke MP, Heath AW, Shokat KM, Zeng Y, Finkelman FD, Linsley PS, Howard M, Goodnow CC: Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med 1994, 179:425-438.