Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells

European Journal of Biochemistry

Volumn 267, Issue 12, 2000, Pages 3604-3612

  Hoischen, Susanne H ^a   Vollmer, Petra ^a   März, Pia ^a   Özbek, Suat ^a   Götze, Katharina S ^b   Peschel, Christian ^b   Jostock, Thomas ^a   Geib, Till ^a   Müllberg, Jürgen ^a   Mechtersheimer, Sabine ^a   Fischer, Martina ^a   Grötzinger, Joachim ^c   Galle, Peter R ^a   Rose John, Stefan ^a,d  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

Cytokine; Interleukin 6 receptor; Kaposi's sarcoma; Viral interleukin 6

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; COLONY FORMATION; DISEASE ASSOCIATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; CELL DIFFERENTIATION; CELL DIVISION; CYTOKINE RECEPTOR GP130; GAP-43 PROTEIN; HEMATOPOIETIC STEM CELLS; HERPESVIRUS 8, HUMAN; HUMANS; INTERLEUKIN-6; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NEURONS; PC12 CELLS; RATS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; VIRAL PROTEINS;

EID: 0001640974     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01389.x     Document Type: Article

References (56)

1. 1. Nador, R.G., Cesarman, E., Chadburn, A., Dawson, D.B., Ansari, M.Q., Sald, J. & Knowles, D.M. (1996) Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 88, 645-656.
2. 2. Cesarman, E., Chang, Y., Moore, P.S., Said, J.W. & Knowles, D.M. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. New Engl. J. Med. 332, 1186-1191.
3. 3. Soulier, J., Grollet, L., Oksenhendler, E., Cacoub, P., Cazals Hatem, D., Babinet, P., d'Agay, M.F., Clauvel, J.P., Raphael, M., Degos, L. et al. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86, 1276-1280.
4. 4. Staskus, K.A., Zhong, W., Gebhard, K., Herndier, B., Wang, H., Renne, R., Beneke, J., Pudney, J., Anderson, D.J., Ganem, D. & Haase, A.T. (1997) Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J. Virol. 71, 715-719.
5. 5. Rettig, M.B., Ma, H.J., Vescio, R.A., Pold, M., Schiller, G., Belson, D., Savage, A., Nishikubo, C., Wu, C., Fraser, J., Said, J.W. & Berenson, J.R. (1997) Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 276, 1851-1854.
6. 6. Staskus, K.A., Sun, R., Miller, G., Racz, P., Jaslowski, A., Metroka, C., Brett-Smith, H. & Haase, A.T. (1999) Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. J. Virol. 73, 4181-4187.
7. 7. Chauhan, D., Bharti, A., Raje, N., Gustafson, E., Pinkus, G.S., Pinkus, J.L., Teoh, G., Hideshima, T., Treon, S.P., Fingeroth, J.D. & Anderson, K.C. (1999) Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells. Blood 93, 1482-1486.
8. 8. Berenson, J.R. & Vescio, R.A. (1999) HHV-8 is present in multiple myeloma patients. Blood 93, 3157-3159.
9. 9. Tarte, K., Chang, Y. & Klein, B. (1999) Kaposi's sarcoma-associated herpesvirus and multiple myeloma: lack of criteria for causality. Blood 93, 3159-3163.
10. 10. Moore, P.S., Boshoff, C., Weiss, R.A. & Chang, Y. (1996) Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274, 1739-1744.
11. 11. Neipel, F., Albrecht, J.C., Ensser, A., Huang, Y.Q., Li, J.J., Friedman Kien, A.E. & Fleckenstein, B. (1997) Human herpesvirus 8 encodes a homolog of interleukin-6. J. Virol. 71, 839-842.
12. 12. Aoki, Y., Jaffe, E.S., Chang, Y., Jones, K., Teruya-Feldstein, J., Moore, P.S. & Tosato, G. (1999) Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood 93, 4034-4043.
13. 13. Yoshizaki, K., Matsuda, T., Nishimoto, N., Kuritani, T., Taeho, L., Aozasa, K., Nakahata, T., Kawai, H., Tagoh, H. & Komori, T. (1989) Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74, 1360-1367.
14. 14. Klein, B., Zhang, X.G., Lu, Z.Y. & Bataille, R. (1995) Interleukin-6 in human multiple myeloma. Blood 85, 863-872.
15. 15. Parravinci, C., Corbellino, M., Paulli, M., Magrini, U., Lazzarino, M., Moore, P.S. & Chang, Y. (1997) Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman's disease. Am. J. Pathol 151, 1517-1522.
16. 16. Burger, R., Neipel, F., Fleckenstein, B., Savino, R., Ciliberto, G., Kalden, J.R. & Gramatzki, M. (1998) Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. Blood 91, 1858-1863.
17. 17. Asou, H., Said, J.W., Yang, R., Munker, R., Park, D.J., Kamada, N. & Koeffler, H.P. (1998) Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells. Blood 91, 2475-2481.
18. 18. Jones, K.D., Aoki, Y., Chang, Y., Moore, P.S., Yarchoan, R. & Tosato, G. (1999) Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells. Blood 94, 2871-2879.
19. 19. Darnell, J.E., Kerr, I.M. & Stark, G.R. (1994) JAK-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421.
20. 20. Taga, T. & Kishimoto, T. (1997) gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15, 797-819.
21. 21. Molden, J., Chang, Y., You, Y., Moore, P.S. & Goldsmith, M.A. (1997) A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J. Biol. Chem. 272, 19625-19631.
22. 22. Wan, X., Wang, H. & Nicholase, J. (1999) Human herpesvirus 8 interleukin-6 (IL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6. J. Virol. 73, 8268-8278.
23. 23. Novick, D., Engelmann, H., Wallach, D. & Rubinstein, M. (1989) Soluble cytokine receptors are present in normal human urine. J. Exp. Med. 170, 1409-1414.
24. 24. Honda, M., Yamamoto, S., Cheng, M., Yasukawa, K., Suzuki, H., Saito, T., Osugi, Y., Tokunaga, T. & Kishimoto, T. (1992) Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J. Immunol. 148, 2175-2180.
25. 25. Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T. & Kishimoto, T. (1989) Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58, 573-581.
26. 26. Mackiewicz, A., Schooltink, H., Heinrich, P.C. & Rose-John, S. (1992) Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins. J. Immunol. 149, 2021-2027.
27. 27. Rose-John, S. & Heinrich, P.C. (1994) Soluble receptors for cytokines and growth factors: generation and biological function. Biochem. J. 300, 281-290.
28. 28. Peters, M., Müller, A. & Rose-John, S. (1998) Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis. Blood 92, 3495-3504.
29. 29. Peters, M., Jacobs, S., Ehlers, M., Vollmer, P., Müllberg, J., Wolf, E., Brem, G., Meyer zum Büschenfelde, K.H. & Rose-John, S. (1996) The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J. Exp. Med. 183, 1399-1406.
30. 30. Peters, M., Schirmacher, P., Goldschmitt, J., Odenthal, M., Peschel, C., Dienes, H.P., Fattori, E., Ciliberto, G., Meyer zum Büschenfelde, K.H. & Rose-John, S. (1997) Extramedullary expansion of hematopoietic progenitor cells in IL-6/sIL-6R double transgenic mice. J. Exp. Med. 185, 755-766.
31. 31. Romano, M., Sironi, M., Toniatti, C., Polentarutti, N., Fruscella, P., Ghezzi, P., Faggioni, R., Luini, W., van Hinsbergh, V., Sozzani, S., Bussolino, F., Poli, V., Ciliberto, G. & Mantovani, A. (1997) Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6, 315-325.
32. 32. Udagawa, N., Takahashi, N., Katagiri, T., Tamura, T., Wada, S., Findlay, D.M., Martin, T.J., Hirota, H., Taga, T., Kishimoto, T. & Suda, T. (1995) Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J. Exp. Med. 182, 1461-1468.
33. 33. Klouche, M., Bhakdi, S., Hemmes, M. & Rose-John, S. (1999) Novel Path of activation of primary human smooth muscle cells: upregulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J. Immunol. 163, 4583-4589.
34. 34. März, P., Cheng, J.-C., Gadient, R.A., Patterson, P., Stoyan, T., Otten, U. & Rose-John, S. (1998) Sympathetic neurons can produce and respond to interleukin-6. Proc. Natl Acad. Sci. USA 95, 3251-3256.
35. 35. März, P., Otten, U. & Rose-John, S. (1999) Neuronal activities of IL-6 type cytokines often depend on soluble cytokine receptors. Eur. J. Neurosci. 11, 2995-3004.
36. 36. van Dam, M., Müllberg, J., Schooltink, H., Stoyan, T., Brakenhoff, J.P., Graeve, L., Heinrich, P.C. & Rose-John, S. (1993) Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding. J. Biol. Chem. 268, 15285-15290.
37. 37. Fischer, M., Goldschmitt, J., Peschel, C., Kallen, K.J., Brakenhoff, J.P.J., Wollmer, A., Grötzinger, J. & Rose-John, S. (1997) A designer cytokine with high activity on human hematopoietic progenitor cells. Nat. Biotech. 15, 142-145.
38. 38. Chen, G.C. & Yang, J.T. (1977) Two-point calibration of circular dichrometer with d-10-camphorsulfonic acid. Anal. Lett. 10, 1195-1207.
39. 39. Gearing, D.P., Ziegler, S.F., Comeau, M.R., Friend, D., Thoma, B., Cosman, D., Park, L. & Mosley, B. (1994) Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. Proc. Natl Acad. Sci. USA 91, 1119-1123.
40. 40. Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T. & Kishimoto, T. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63, 1149-1157.
41. 41. Vollmer, P., Oppmann, B., Voltz, N., Fischer, M. & Rose-John, S. (1999) A role for the immunoglobulin-like domain of the human IL-6 receptor: intracellular protein transport and shedding. Eur J. Biochem. 263, 438-446.
42. 42. Somers, W., Stahl, M. & Seehra, J.S. (1997) 1.9 Å crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling. EMBO J. 16, 989-997.
43. 43. Xu, G.Y., Yu, H.A., Hong, J., Stahl, M., McDonagh, T., Kay, L.E. & Cumming, D.A. (1997) Solution structure of recombinant human interleukin-6. J. Mol Biol. 268, 468-481.
44. 44. März, P., Herget, T., Lang, E., Otten, U. & Rose-John, S. (1997) Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation. Eur. J. Neurosci. 9, 2765-2773.
45. 45. Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Kawanishi, Y., Seed, B., Taniguchi, T., Hirano, T. & Kishimoto, T. (1988) Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science 241, 825-828.
46. 46. März, P., Gadient, R.A. & Otten, U. (1996) Expression of interleukin-6 receptor (IL-6R) and gp130 mRNA in PC 12 cells and sympathetic neurons: modulation by tumor necrosis factor alpha (TNF-alpha). Brain Res. 706, 71-79.
47. 47. März, P., Heese, K., Hock, C., Golombowski, S., Muller-Spahn, F., Rose-John, S. & Otten, U. (1997) Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients. Neurosci. Lett 239, 29-32.
48. 48. März, P., Heese, K., Dimitriades-Schmutz, B., Rose-John, S. & Otten, U. (1999) Role of interleukin-6 and soluble IL-6 receptor in region specific induction of astrocytic differentiation and neurotrophin expression. Glia 26, 191-200.
49. 49. Sui, X., Tsuji, K., Tanaka, R., Tajima, S., Muraoka, K., Ebihara, Y., Ikebuchi, K., Yasukawa, K., Taga, T., Kishimoto, T. & Nakahata, T. (1995) gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells. Proc. Natl Acad. Sci. USA 92, 2859-2863.
50. -Cd38 cells stimulated by multiple growth factors in vitro. Blood 94, 1926-1932.
51. 51. Kollet, O., Aviram, R., Chebath, J., ben-Hur, H., Nagler, A., Shultz, L., Revel, M. & Lapidot, T. (1999) The soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro maintenance and proliferation of human CD34 (+) CD38 (-/low) cells capable of repopulating severe combined immunodeficiency mice. Blood 94, 923-931.
52. 52. Tajima, S., Tsuji, K., Ebihara, Y., Sui, X., Tanaka, R., Muraoka, K., Yoshida, M., Yamada, K., Yasukawa, K., Taga, T., Kishimoto, T. & Nakahata, T. (1996) Analysis of interleukin-6 receptor and gp130 expressions and proliferative capability of human CD34+ cells. J. Exp. Med. 184, 1357-1364.
53. 53. Suematsu, S., Matsusaka, T., Matsuda, T., Hirano, T. & Kishimoto, T. (1993) Interleukin-6 in myeloma/plasmacytoma. Int. Rev. Exp Pathol A 34, 91-98.
54. 54. Suematsu, S., Matsuda, T., Aozasa, K., Akira, S., Nakano, N., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T. & Kishimoto, T. (1989) IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc. Natl Acad. Sci. USA 86, 7547-7551.
55. 55. Suematsu, S., Matsusaka, T., Matsuda, T., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T. & Kishimoto, T. (1992) Generation of plasmacytomas with the chromosomal translocation t (12; 15) in interleukin 6 transgenic mice. Proc. Natl Acad. Sci. USA 89, 232-235.
56. 56. Schirmacher, P., Peters, M., Ciliberto, G., Fattori, E., Lotz, J., Meyer zum Büschenfelde, K.H. & Rose-John, S. (1998) Hepatocellular hyperplasia, plasmacytoma formation, and extracellular hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice. Am. J. Pathol. 153, 639-648.