메뉴 건너뛰기




Volumn 7, Issue 6, 2012, Pages 677-685

Recent developments in bone anabolic therapy for osteoporosis

Author keywords

anabolic agents; BMP signaling; osteoporosis; RNAi; Wnt signaling

Indexed keywords

ANABOLIC AGENT; ANTAGOMIR; APTAMER; BETA CATENIN; BISPHOSPHONIC ACID DERIVATIVE; BONE DENSITY CONSERVATION AGENT; BONE MORPHOGENETIC PROTEIN; DICKKOPF 1 PROTEIN; FRIZZLED PROTEIN; HUMAN GROWTH HORMONE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MICRORNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE[1-34]; PLACEBO; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT PARATHYROID HORMONE; ROMOSOZUMAB; SCLEROSTIN; SMAD4 PROTEIN; SMALL INTERFERING RNA; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNINDEXED DRUG; WNT PROTEIN;

EID: 84869775154     PISSN: 17446651     EISSN: 17448417     Source Type: Journal    
DOI: 10.1586/eem.12.63     Document Type: Article
Times cited : (6)

References (106)
  • 1
    • 33745490531 scopus 로고    scopus 로고
    • Periosteal remodeling at the femoral neck in nonhuman primates
    • Bliziotes M, Sibonga JD, Turner RT, Orwoll E. Periosteal remodeling at the femoral neck in nonhuman primates. J. Bone Miner. Res. 21(7), 1060-1067 (2006).
    • (2006) J. Bone Miner. Res. , vol.21 , Issue.7 , pp. 1060-1067
    • Bliziotes, M.1    Sibonga, J.D.2    Turner, R.T.3    Orwoll, E.4
  • 2
    • 0142122926 scopus 로고    scopus 로고
    • Toward an expanded understanding of the role of the periosteum in skeletal health
    • Orwoll ES. Toward an expanded understanding of the role of the periosteum in skeletal health. J. Bone Miner. Res. 18(6), 949-954 (2003).
    • (2003) J. Bone Miner. Res. , vol.18 , Issue.6 , pp. 949-954
    • Orwoll, E.S.1
  • 4
    • 79959481579 scopus 로고    scopus 로고
    • Role of bisphosphonates in the management of postmenopausal osteoporosis: An update on recent safety anxieties
    • Hollick RJ, Reid DM. Role of bisphosphonates in the management of postmenopausal osteoporosis: an update on recent safety anxieties. Menopause Int. 17(2), 66-72 (2011).
    • (2011) Menopause Int , vol.17 , Issue.2 , pp. 66-72
    • Hollick, R.J.1    Reid, D.M.2
  • 5
    • 79955722153 scopus 로고    scopus 로고
    • Bisphosphonate use and atypical fractures of the femoral shaft
    • Schilcher J, Michaëlsson K, Aspenberg P. Bisphosphonate use and atypical fractures of the femoral shaft. N. Engl. J. Med. 364(18), 1728-1737 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , Issue.18 , pp. 1728-1737
    • Schilcher, J.1    Michaëlsson, K.2    Aspenberg, P.3
  • 7
    • 21344454577 scopus 로고    scopus 로고
    • Parathyroid hormone and teriparatide for the treatment of osteoporosis: A review of the evidence and suggested guidelines for its use
    • Hodsman AB, Bauer DC, Dempster DW et al. Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use. Endocr. Rev. 26(5), 688-703 (2005).
    • (2005) Endocr. Rev. , vol.26 , Issue.5 , pp. 688-703
    • Hodsman, A.B.1    Bauer, D.C.2    Dempster, D.W.3
  • 8
    • 34248577022 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
    • Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40(6), 1434-1446 (2007).
    • (2007) Bone , vol.40 , Issue.6 , pp. 1434-1446
    • Jilka, R.L.1
  • 9
    • 36048935393 scopus 로고    scopus 로고
    • IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone
    • Wang Y, Nishida S, Boudignon BM et al. IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J. Bone Miner. Res. 22(9), 1329-1337 (2007).
    • (2007) J. Bone Miner. Res. , vol.22 , Issue.9 , pp. 1329-1337
    • Wang, Y.1    Nishida, S.2    Boudignon, B.M.3
  • 10
    • 0036708145 scopus 로고    scopus 로고
    • Insulin-like growth factor i is required for the anabolic actions of parathyroid hormone on mouse bone
    • Bikle DD, Sakata T, Leary C et al. Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. J. Bone Miner. Res. 17(9), 1570-1578 (2002).
    • (2002) J. Bone Miner. Res. , vol.17 , Issue.9 , pp. 1570-1578
    • Bikle, D.D.1    Sakata, T.2    Leary, C.3
  • 12
    • 0141684971 scopus 로고    scopus 로고
    • The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    • PaTH Study Investigators
    • Black DM, Greenspan SL, Ensrud KE et al.; PaTH Study Investigators. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N. Engl. J. Med. 349(13), 1207-1215 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , Issue.13 , pp. 1207-1215
    • Black, D.M.1    Greenspan, S.L.2    Ensrud, K.E.3
  • 13
    • 0035837553 scopus 로고    scopus 로고
    • Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
    • Neer RM, Arnaud CD, Zanchetta JR et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344(19), 1434-1441 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , Issue.19 , pp. 1434-1441
    • Neer, R.M.1    Arnaud, C.D.2    Zanchetta, J.R.3
  • 14
    • 84867239128 scopus 로고    scopus 로고
    • Six months of parathyroid hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: The PTH and Ibandronate Combination Study (PICS) Randomized trial
    • Schafer AL, Sellmeyer DE, Palermo L et al. Six months of parathyroid hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and Ibandronate Combination Study (PICS) Randomized trial. J. Clin. Endocrinol. Metab. 97(10), 3522-3529 (2012).
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , Issue.10 , pp. 3522-3529
    • Schafer, A.L.1    Sellmeyer, D.E.2    Palermo, L.3
  • 15
    • 80755127898 scopus 로고    scopus 로고
    • Effects of intermittent parathyroid hormone treatment on osteoprogenitor cells in postmenopausal women
    • Drake MT, Srinivasan B, Mödder UI et al. Effects of intermittent parathyroid hormone treatment on osteoprogenitor cells in postmenopausal women. Bone 49(3), 349-355 (2011).
    • (2011) Bone , vol.49 , Issue.3 , pp. 349-355
    • Drake, M.T.1    Srinivasan, B.2    Mödder, U.I.3
  • 16
    • 0036001310 scopus 로고    scopus 로고
    • Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety
    • Vahle JL, Sato M, Long GG et al. Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety. Toxicol. Pathol. 30(3), 312-321 (2002).
    • (2002) Toxicol. Pathol. , vol.30 , Issue.3 , pp. 312-321
    • Vahle, J.L.1    Sato, M.2    Long, G.G.3
  • 17
    • 77951644239 scopus 로고    scopus 로고
    • Effects of teriparatide, alendronate, or both in women with postmenopausal osteoporosis
    • Finkelstein JS, Wyland JJ, Lee H, Neer RM. Effects of teriparatide, alendronate, or both in women with postmenopausal osteoporosis. J. Clin. Endocrinol. Metab. 95(4), 1838-1845 (2010).
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , Issue.4 , pp. 1838-1845
    • Finkelstein, J.S.1    Wyland, J.J.2    Lee, H.3    Neer, R.M.4
  • 18
    • 84862651682 scopus 로고    scopus 로고
    • The use of combination therapy in the treatment of postmenopausal osteoporosis
    • Compston J. The use of combination therapy in the treatment of postmenopausal osteoporosis. Endocrine 41(1), 11-18 (2012).
    • (2012) Endocrine , vol.41 , Issue.1 , pp. 11-18
    • Compston, J.1
  • 19
    • 0033916327 scopus 로고    scopus 로고
    • Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: A comparison of human parathyroid hormone 1-34, parathyroid hormone-related protein 1-36, and SDZ-parathyroid hormone 893
    • Stewart AF, Cain RL, Burr DB, Jacob D, Turner CH, Hock JM. Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: a comparison of human parathyroid hormone 1-34, parathyroid hormone-related protein 1-36, and SDZ-parathyroid hormone 893. J. Bone Miner. Res. 15(8), 1517-1525 (2000).
    • (2000) J. Bone Miner. Res. , vol.15 , Issue.8 , pp. 1517-1525
    • Stewart, A.F.1    Cain, R.L.2    Burr, D.B.3    Jacob, D.4    Turner, C.H.5    Hock, J.M.6
  • 20
    • 73149096996 scopus 로고    scopus 로고
    • Agonists and allosteric modulators of the calcium-sensing receptor and their therapeutic applications
    • Saidak Z, Brazier M, Kamel S, Mentaverri R. Agonists and allosteric modulators of the calcium-sensing receptor and their therapeutic applications. Mol. Pharmacol. 76(6), 1131-1144 (2009).
    • (2009) Mol. Pharmacol. , vol.76 , Issue.6 , pp. 1131-1144
    • Saidak, Z.1    Brazier, M.2    Kamel, S.3    Mentaverri, R.4
  • 21
    • 79961216005 scopus 로고    scopus 로고
    • The effects of ronacaleret, a calcium-sensing receptor antagonist, on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mineral density
    • Fitzpatrick LA, Dabrowski CE, Cicconetti G et al. The effects of ronacaleret, a calcium-sensing receptor antagonist, on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mineral density. J. Clin. Endocrinol. Metab. 96(8), 2441-2449 (2011).
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , Issue.8 , pp. 2441-2449
    • Fitzpatrick, L.A.1    Dabrowski, C.E.2    Cicconetti, G.3
  • 22
    • 0037136577 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • 944; author reply 943
    • Little RD, Recker RR, Johnson ML. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 347(12), 943-944; author reply 943 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , Issue.12 , pp. 943-1012
    • Little, R.D.1    Recker, R.R.2    Johnson, M.L.3
  • 23
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Osteoporosis-Pseudoglioma Syndrome Collaborative Group
    • Gong Y, Slee RB, Fukai N et al.; Osteoporosis-Pseudoglioma Syndrome Collaborative Group. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107(4), 513-523 (2001).
    • (2001) Cell , vol.107 , Issue.4 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3
  • 24
    • 0030978351 scopus 로고    scopus 로고
    • β-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. β-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16(13), 3797-3804 (1997).
    • (1997) EMBO J , vol.16 , Issue.13 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 25
    • 25844509347 scopus 로고    scopus 로고
    • Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression
    • Gaur T, Lengner CJ, Hovhannisyan H et al. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J. Biol. Chem. 280(39), 33132-33140 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.39 , pp. 33132-33140
    • Gaur, T.1    Lengner, C.J.2    Hovhannisyan, H.3
  • 26
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    • Semënov M, Tamai K, He X. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J. Biol. Chem. 280(29), 26770-26775 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.29 , pp. 26770-26775
    • Semënov, M.1    Tamai, K.2    He, X.3
  • 27
    • 33845927993 scopus 로고    scopus 로고
    • Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation
    • van Bezooijen RL, Svensson JP, Eefting D et al. Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation. J. Bone Miner. Res. 22(1), 19-28 (2007).
    • (2007) J. Bone Miner. Res. , vol.22 , Issue.1 , pp. 19-28
    • Van Bezooijen, R.L.1    Svensson, J.P.2    Eefting, D.3
  • 28
    • 33846449190 scopus 로고    scopus 로고
    • Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
    • Ellies DL, Viviano B, McCarthy J et al. Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J. Bone Miner. Res. 21(11), 1738-1749 (2006).
    • (2006) J. Bone Miner. Res. , vol.21 , Issue.11 , pp. 1738-1749
    • Ellies, D.L.1    Viviano, B.2    McCarthy, J.3
  • 29
    • 22244474640 scopus 로고    scopus 로고
    • Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
    • Loots GG, Kneissel M, Keller H et al. Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res. 15(7), 928-935 (2005).
    • (2005) Genome Res. , vol.15 , Issue.7 , pp. 928-935
    • Loots, G.G.1    Kneissel, M.2    Keller, H.3
  • 30
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    • Li X, Ominsky MS, Warmington KS et al. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J. Bone Miner. Res. 24(4), 578-588 (2009).
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.4 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3
  • 31
    • 78650958526 scopus 로고    scopus 로고
    • Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    • Padhi D, Jang G, Stouch B, Fang L, Posvar E. Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J. Bone Miner. Res. 26(1), 19-26 (2011).
    • (2011) J. Bone Miner. Res. , vol.26 , Issue.1 , pp. 19-26
    • Padhi, D.1    Jang, G.2    Stouch, B.3    Fang, L.4    Posvar, E.5
  • 32
    • 77956863339 scopus 로고    scopus 로고
    • Sclerostin: A gem from the genome leads to bone-building antibodies
    • Paszty C, Turner CH, Robinson MK. Sclerostin: a gem from the genome leads to bone-building antibodies. J. Bone Miner. Res. 25(9), 1897-1904 (2010).
    • (2010) J. Bone Miner. Res. , vol.25 , Issue.9 , pp. 1897-1904
    • Paszty, C.1    Turner, C.H.2    Robinson, M.K.3
  • 33
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden LM, Mao J, Belsky J et al. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346(20), 1513-1521 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , Issue.20 , pp. 1513-1521
    • Boyden, L.M.1    Mao, J.2    Belsky, J.3
  • 34
    • 33748156090 scopus 로고    scopus 로고
    • Dkk1- mediated inhibition of Wnt signaling in bone results in osteopenia
    • Li J, Sarosi I, Cattley RC et al. Dkk1- mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 39(4), 754-766 (2006).
    • (2006) Bone , vol.39 , Issue.4 , pp. 754-766
    • Li, J.1    Sarosi, I.2    Cattley, R.C.3
  • 35
    • 33646856033 scopus 로고    scopus 로고
    • Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass
    • Morvan F, Boulukos K, Clément-Lacroix P et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J. Bone Miner. Res. 21(6), 934-945 (2006).
    • (2006) J. Bone Miner. Res. , vol.21 , Issue.6 , pp. 934-945
    • Morvan, F.1    Boulukos, K.2    Clément-Lacroix, P.3
  • 36
    • 33846949349 scopus 로고    scopus 로고
    • Dickkopf-1 is a master regulator of joint remodeling
    • Diarra D, Stolina M, Polzer K et al. Dickkopf-1 is a master regulator of joint remodeling. Nat. Med. 13(2), 156-163 (2007).
    • (2007) Nat. Med. , vol.13 , Issue.2 , pp. 156-163
    • Diarra, D.1    Stolina, M.2    Polzer, K.3
  • 37
    • 61849137831 scopus 로고    scopus 로고
    • Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma
    • Heath DJ, Chantry AD, Buckle CH et al. Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma. J. Bone Miner. Res. 24(3), 425-436 (2009).
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.3 , pp. 425-436
    • Heath, D.J.1    Chantry, A.D.2    Buckle, C.H.3
  • 38
    • 79960509237 scopus 로고    scopus 로고
    • A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody
    • Glantschnig H, Scott K, Hampton R et al. A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody. J. Pharmacol. Exp. Ther. 338(2), 568-578 (2011).
    • (2011) J. Pharmacol. Exp. Ther. , vol.338 , Issue.2 , pp. 568-578
    • Glantschnig, H.1    Scott, K.2    Hampton, R.3
  • 39
    • 78649723963 scopus 로고    scopus 로고
    • Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
    • Heiland GR, Zwerina K, Baum W et al. Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression. Ann. Rheum. Dis. 69(12), 2152-2159 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , Issue.12 , pp. 2152-2159
    • Heiland, G.R.1    Zwerina, K.2    Baum, W.3
  • 40
    • 67650431302 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 114(2), 371-379 (2009).
    • (2009) Blood , vol.114 , Issue.2 , pp. 371-379
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3
  • 41
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi Y, Massagué J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113(6), 685-700 (2003).
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 42
    • 21344455768 scopus 로고    scopus 로고
    • BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
    • Miyazono K, Maeda S, Imamura T. BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev. 16(3), 251-263 (2005).
    • (2005) Cytokine Growth Factor Rev , vol.16 , Issue.3 , pp. 251-263
    • Miyazono, K.1    Maeda, S.2    Imamura, T.3
  • 43
    • 0032014216 scopus 로고    scopus 로고
    • Human Smad3 and Smad4 are sequencespecific transcription activators
    • Zawel L, Dai JL, Buckhaults P et al. Human Smad3 and Smad4 are sequencespecific transcription activators. Mol. Cell 1(4), 611-617 (1998).
    • (1998) Mol. Cell , vol.1 , Issue.4 , pp. 611-617
    • Zawel, L.1    Dai, J.L.2    Buckhaults, P.3
  • 44
    • 0034641617 scopus 로고    scopus 로고
    • A RUNX2/PEBP2α A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia
    • Zhang YW, Yasui N, Ito K et al. A RUNX2/PEBP2α A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc. Natl Acad. Sci. USA 97(19), 10549-10554 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , Issue.19 , pp. 10549-10554
    • Zhang, Y.W.1    Yasui, N.2    Ito, K.3
  • 46
    • 80855130966 scopus 로고    scopus 로고
    • Altered plasma membrane dynamics of bone morphogenetic protein receptor type Ia in a low bone mass mouse model
    • Bragdon B, D'Angelo A, Gurski L et al. Altered plasma membrane dynamics of bone morphogenetic protein receptor type Ia in a low bone mass mouse model. Bone 50(1), 189-199 (2012).
    • (2012) Bone , vol.50 , Issue.1 , pp. 189-199
    • Bragdon, B.1    D'Angelo, A.2    Gurski, L.3
  • 48
    • 35748953461 scopus 로고    scopus 로고
    • Conditional deletion of gremlin causes a transient increase in bone formation and bone mass
    • Gazzerro E, Smerdel-Ramoya A, Zanotti S et al. Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. J. Biol. Chem. 282(43), 31549-31557 (2007).
    • (2007) J. Biol. Chem. , vol.282 , Issue.43 , pp. 31549-31557
    • Gazzerro, E.1    Smerdel-Ramoya, A.2    Zanotti, S.3
  • 49
    • 0037733130 scopus 로고    scopus 로고
    • Skeletal overexpression of noggin results in osteopenia and reduced bone formation
    • Devlin RD, Du Z, Pereira RC et al. Skeletal overexpression of noggin results in osteopenia and reduced bone formation. Endocrinology 144(5), 1972-1978 (2003).
    • (2003) Endocrinology , vol.144 , Issue.5 , pp. 1972-1978
    • Du Devlin, R.D.Z.1    Pereira, R.C.2
  • 50
    • 58149109128 scopus 로고    scopus 로고
    • The adjunctive effect of a binding peptide on bone morphogenetic protein enhanced bone healing in a rodent model of spinal fusion
    • Alanay A, Chen C, Lee S et al. The adjunctive effect of a binding peptide on bone morphogenetic protein enhanced bone healing in a rodent model of spinal fusion. Spine 33(16), 1709-1713 (2008).
    • (2008) Spine , vol.33 , Issue.16 , pp. 1709-1713
    • Alanay, A.1    Chen, C.2    Lee, S.3
  • 51
    • 0001783646 scopus 로고    scopus 로고
    • Principles of Bone Biology (2nd Edition). Bilezikian JP, Rasisz LG, Rodan GA et al. (Eds). Academic Press, NY, USA
    • Rosen V, Wozney JM. Bone morphogenetic protein. In: Principles of Bone Biology (2nd Edition). Bilezikian JP, Rasisz LG, Rodan GA et al. (Eds). Academic Press, NY, USA, 661-671 (2002).
    • (2002) Bone Morphogenetic Protein , pp. 661-671
    • Rosen, V.1    Wozney, J.M.2
  • 52
    • 0034864799 scopus 로고    scopus 로고
    • Proteasome inhibitors: From research tools to drug candidates
    • Kisselev AF, Goldberg AL. Proteasome inhibitors: from research tools to drug candidates. Chem. Biol. 8(8), 739-758 (2001).
    • (2001) Chem. Biol. , vol.8 , Issue.8 , pp. 739-758
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 53
    • 0038819051 scopus 로고    scopus 로고
    • Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro
    • Garrett IR, Chen D, Gutierrez G et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J. Clin. Invest. 111(11), 1771-1782 (2003).
    • (2003) J. Clin. Invest. , vol.111 , Issue.11 , pp. 1771-1782
    • Garrett, I.R.1    Chen, D.2    Gutierrez, G.3
  • 54
    • 35548989214 scopus 로고    scopus 로고
    • Differential ubiquitination of Smad1 mediated by CHIP: Implications in the regulation of the bone morphogenetic protein signaling pathway
    • Li RF, Shang Y, Liu D, Ren ZS, Chang Z, Sui SF. Differential ubiquitination of Smad1 mediated by CHIP: implications in the regulation of the bone morphogenetic protein signaling pathway. J. Mol. Biol. 374(3), 777-790 (2007).
    • (2007) J. Mol. Biol. , vol.374 , Issue.3 , pp. 777-790
    • Li, R.F.1    Shang, Y.2    Liu, D.3    Ren, Z.S.4    Chang, Z.5    Sui, S.F.6
  • 55
    • 0034967925 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway and proteasome inhibitors
    • Myung J, Kim KB, Crews CM. The ubiquitin-proteasome pathway and proteasome inhibitors. Med. Res. Rev. 21(4), 245-273 (2001).
    • (2001) Med. Res. Rev. , vol.21 , Issue.4 , pp. 245-273
    • Myung, J.1    Kim, K.B.2    Crews, C.M.3
  • 56
    • 48649104139 scopus 로고    scopus 로고
    • Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1
    • Lu K, Yin X, Weng T et al. Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat. Cell Biol. 10(8), 994-1002 (2008).
    • (2008) Nat. Cell Biol. , vol.10 , Issue.8 , pp. 994-1002
    • Lu, K.1    Yin, X.2    Weng, T.3
  • 57
    • 84871033315 scopus 로고    scopus 로고
    • Highly expressed CKIP-1 and lowly expressed Smad1/5 in aged callus specimen
    • Shenzhen China 28-31 October
    • Guo B, Zhang B, Wu H et al. Highly expressed CKIP-1 and lowly expressed Smad1/5 in aged callus specimen. Presented at: 2nd Asia-Pacific Osteoporosis and Bone Meeting. Shenzhen, China, 28-31 October 2011.
    • (2011) 2nd Asia-Pacific Osteoporosis and Bone Meeting
    • Guo, B.1    Zhang, B.2    Wu, H.3
  • 58
    • 0346024110 scopus 로고    scopus 로고
    • TGF-β signaling in human skeletal and patterning disorders
    • Serra R, Chang C. TGF-β signaling in human skeletal and patterning disorders. Birth Defects Res. C Embryo Today 69(4), 333-351 (2003).
    • (2003) Birth Defects Res. C Embryo Today , vol.69 , Issue.4 , pp. 333-351
    • Serra, R.1    Chang, C.2
  • 59
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-β-Smad signalling
    • ten Dijke P, Hill CS. New insights into TGF-β-Smad signalling. Trends Biochem. Sci. 29(5), 265-273 (2004).
    • (2004) Trends Biochem. Sci. , vol.29 , Issue.5 , pp. 265-273
    • Ten Dijke, P.1    Hill, C.S.2
  • 60
    • 30744450220 scopus 로고    scopus 로고
    • Camurati-Engelmann disease: Review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment
    • Janssens K, Vanhoenacker F, Bonduelle M et al. Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment. J. Med. Genet. 43(1), 1-11 (2006).
    • (2006) J. Med. Genet. , vol.43 , Issue.1 , pp. 1-11
    • Janssens, K.1    Vanhoenacker, F.2    Bonduelle, M.3
  • 61
    • 0031053149 scopus 로고    scopus 로고
    • Growth factors and bone formation in osteoporosis: Roles for IGF-I and TGF-β
    • Marie P. Growth factors and bone formation in osteoporosis: roles for IGF-I and TGF-β. Rev. Rhum. Engl. Ed. 64(1), 44-53 (1997).
    • (1997) Rev. Rhum. Engl. Ed. , vol.64 , Issue.1 , pp. 44-53
    • Marie, P.1
  • 62
    • 0037370988 scopus 로고    scopus 로고
    • Growth hormone increases bone mineral content in postmenopausal osteoporosis: A randomized placebo-controlled trial
    • Landin-Wilhelmsen K, Nilsson A, Bosaeus I, Bengtsson BA. Growth hormone increases bone mineral content in postmenopausal osteoporosis: a randomized placebo-controlled trial. J. Bone Miner. Res. 18(3), 393-405 (2003).
    • (2003) J. Bone Miner. Res. , vol.18 , Issue.3 , pp. 393-405
    • Landin-Wilhelmsen, K.1    Nilsson, A.2    Bosaeus, I.3    Bengtsson, B.A.4
  • 63
    • 3342915553 scopus 로고    scopus 로고
    • SiRNAs and miRNAs: A meeting report on RNA silencing
    • He Z, Sontheimer EJ. 'siRNAs and miRNAs': a meeting report on RNA silencing. RNA 10(8), 1165-1173 (2004).
    • (2004) RNA , vol.10 , Issue.8 , pp. 1165-1173
    • He, Z.1    Sontheimer, E.J.2
  • 64
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391(6669), 806-811 (1998).
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 65
    • 0142011652 scopus 로고    scopus 로고
    • Oligonucleotide-based knockdown technologies: Antisense versus RNA interference
    • Achenbach TV, Brunner B, Heermeier K. Oligonucleotide-based knockdown technologies: antisense versus RNA interference. Chembiochem 4(10), 928-935 (2003).
    • (2003) Chembiochem , vol.4 , Issue.10 , pp. 928-935
    • Achenbach, T.V.1    Brunner, B.2    Heermeier, K.3
  • 66
    • 3142615372 scopus 로고    scopus 로고
    • The RNAi revolution
    • Novina CD, Sharp PA. The RNAi revolution. Nature 430(6996), 161-164 (2004).
    • (2004) Nature , vol.430 , Issue.6996 , pp. 161-164
    • Novina, C.D.1    Sharp, P.A.2
  • 67
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond SM, Bernstein E, Beach D, Hannon GJ. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404(6775), 293-296 (2000).
    • (2000) Nature , vol.404 , Issue.6775 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 68
    • 77952680862 scopus 로고    scopus 로고
    • Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: A proof-of-concept study
    • Geisbert TW, Lee AC, Robbins M et al. Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study. Lancet 375(9729), 1896-1905 (2010).
    • (2010) Lancet , vol.375 , Issue.9729 , pp. 1896-1905
    • Geisbert, T.W.1    Lee, A.C.2    Robbins, M.3
  • 69
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson BL, McCray PB Jr. Current prospects for RNA interference-based therapies. Nat. Rev. Genet. 12(5), 329-340 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , Issue.5 , pp. 329-340
    • Davidson, B.L.1    McCray Jr., P.B.2
  • 70
    • 58149215702 scopus 로고    scopus 로고
    • Chitosan/siRNA nanoparticle-mediated TNF-α knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
    • Howard KA, Paludan SR, Behlke MA, Besenbacher F, Deleuran B, Kjems J. Chitosan/siRNA nanoparticle-mediated TNF-α knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol. Ther. 17(1), 162-168 (2009).
    • (2009) Mol. Ther. , vol.17 , Issue.1 , pp. 162-168
    • Howard, K.A.1    Paludan, S.R.2    Behlke, M.A.3    Besenbacher, F.4    Deleuran, B.5    Kjems, J.6
  • 71
    • 77957670799 scopus 로고    scopus 로고
    • Knockdown of Fcg receptor III in an arthritic temporomandibular joint reduces the nociceptive response in rats
    • Kramer PR, Puri J, Bellinger LL. Knockdown of Fcg receptor III in an arthritic temporomandibular joint reduces the nociceptive response in rats. Arthritis Rheum. 62(10), 3109-3118 (2010).
    • (2010) Arthritis Rheum , vol.62 , Issue.10 , pp. 3109-3118
    • Kramer, P.R.1    Puri, J.2    Bellinger, L.L.3
  • 72
    • 77953621091 scopus 로고    scopus 로고
    • SiRNA knockdown of RANK signaling to control osteoclast-mediated bone resorption
    • Wang Y, Grainger DW. siRNA knockdown of RANK signaling to control osteoclast-mediated bone resorption. Pharm. Res. 27(7), 1273-1284 (2010).
    • (2010) Pharm. Res. , vol.27 , Issue.7 , pp. 1273-1284
    • Wang, Y.1    Grainger, D.W.2
  • 73
    • 84865306003 scopus 로고    scopus 로고
    • RNA therapeutics targeting osteoclast-mediated excessive bone resorption
    • Wang Y, Grainger DW. RNA therapeutics targeting osteoclast-mediated excessive bone resorption. Adv. Drug Deliv. Rev. 64(12), 1341-1357 (2012).
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , Issue.12 , pp. 1341-1357
    • Wang, Y.1    Grainger, D.W.2
  • 74
    • 34547453984 scopus 로고    scopus 로고
    • Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis
    • Buckbinder L, Crawford DT, Qi H et al. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc. Natl Acad. Sci. USA 104(25), 10619-10624 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.25 , pp. 10619-10624
    • Buckbinder, L.1    Crawford, D.T.2    Qi, H.3
  • 75
    • 84868290353 scopus 로고    scopus 로고
    • Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases
    • Ke HZ, Richards WG, Li X, Ominsky MS. Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases. Endocr. Rev. 33(5), 747-783 (2012).
    • (2012) Endocr. Rev. , vol.33 , Issue.5 , pp. 747-783
    • Ke, H.Z.1    Richards, W.G.2    Li, X.3    Ominsky, M.S.4
  • 76
    • 0037434552 scopus 로고    scopus 로고
    • Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
    • Baert F, Noman M, Vermeire S et al. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N. Engl. J. Med. 348(7), 601-608 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , Issue.7 , pp. 601-608
    • Baert, F.1    Noman, M.2    Vermeire, S.3
  • 77
    • 0242551656 scopus 로고    scopus 로고
    • Activation of the Wnt pathway in non small cell lung cancer: Evidence of dishevelled overexpression
    • Uematsu K, He B, You L, Xu Z, McCormick F, Jablons DM. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene 22(46), 7218-7221 (2003).
    • (2003) Oncogene , vol.22 , Issue.46 , pp. 7218-7221
    • Uematsu, K.1    He, B.2    You, L.3    Xu, Z.4    McCormick, F.5    Jablons, D.M.6
  • 78
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2), 281-297 (2004).
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 79
    • 60149088848 scopus 로고    scopus 로고
    • Origins and Mechanisms of miRNAs and siRNAs
    • Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell 136(4), 642-655 (2009).
    • (2009) Cell , vol.136 , Issue.4 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 80
    • 34249946434 scopus 로고    scopus 로고
    • The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells
    • Laneve P, Di Marcotullio L, Gioia U et al. The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. Proc. Natl Acad. Sci. USA 104(19), 7957-7962 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.19 , pp. 7957-7962
    • Laneve, P.1    Di Marcotullio, L.2    Gioia, U.3
  • 81
    • 70450225266 scopus 로고    scopus 로고
    • MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation
    • Song G, Zhang Y, Wang L. MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J. Biol. Chem. 284(46), 31921-31927 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.46 , pp. 31921-31927
    • Song, G.1    Zhang, Y.2    Wang, L.3
  • 82
    • 49749107841 scopus 로고    scopus 로고
    • Aberrant expression of oncogenic and tumorsuppressive microRNAs in cervical cancer is required for cancer cell growth
    • Wang X, Tang S, Le SY et al. Aberrant expression of oncogenic and tumorsuppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 3(7), e2557 (2008).
    • (2008) PLoS One , vol.3 , Issue.7
    • Wang, X.1    Tang, S.2    Le, S.Y.3
  • 83
    • 0041691111 scopus 로고    scopus 로고
    • MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
    • Zeng Y, Yi R, Cullen BR. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl Acad. Sci. USA 100(17), 9779-9784 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.17 , pp. 9779-9784
    • Zeng, Y.1    Yi, R.2    Cullen, B.R.3
  • 84
    • 28444449496 scopus 로고    scopus 로고
    • The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development
    • Hornstein E, Mansfield JH, Yekta S et al. The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature 438(7068), 671-674 (2005).
    • (2005) Nature , vol.438 , Issue.7068 , pp. 671-674
    • Hornstein, E.1    Mansfield, J.H.2    Yekta, S.3
  • 85
    • 79952847453 scopus 로고    scopus 로고
    • Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis
    • Nie X, Wang Q, Jiao K. Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis. Mech. Dev. 128(3-4), 200-207 (2011).
    • (2011) Mech. Dev. , vol.128 , Issue.3-4 , pp. 200-207
    • Nie, X.1    Wang, Q.2    Jiao, K.3
  • 86
    • 52949114558 scopus 로고    scopus 로고
    • A microRNA signature for a BMP2-induced osteoblast lineage commitment program
    • Li Z, Hassan MQ, Volinia S et al. A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc. Natl Acad. Sci. USA 105(37), 13906-13911 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.37 , pp. 13906-13911
    • Li, Z.1    Hassan, M.Q.2    Volinia, S.3
  • 87
    • 80051484363 scopus 로고    scopus 로고
    • MicroRNA expression during osteogenic differentiation of human multipotent mesenchymal stromal cells from bone marrow
    • Gao J, Yang T, Han J et al. MicroRNA expression during osteogenic differentiation of human multipotent mesenchymal stromal cells from bone marrow. J. Cell. Biochem. 112(7), 1844-1856 (2011).
    • (2011) J. Cell. Biochem. , vol.112 , Issue.7 , pp. 1844-1856
    • Gao, J.1    Yang, T.2    Han, J.3
  • 88
    • 57449119515 scopus 로고    scopus 로고
    • Human multipotent stromal cells from bone marrow and microRNA: Regulation of differentiation and leukemia inhibitory factor expression
    • Oskowitz AZ, Lu J, Penfornis P et al. Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression. Proc. Natl Acad. Sci. USA 105(47), 18372-18377 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.47 , pp. 18372-18377
    • Oskowitz, A.Z.1    Lu, J.2    Penfornis, P.3
  • 89
    • 77149136767 scopus 로고    scopus 로고
    • MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation
    • Huang J, Zhao L, Xing L, Chen D. MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells 28(2), 357-364 (2010).
    • (2010) Stem Cells , vol.28 , Issue.2 , pp. 357-364
    • Huang, J.1    Zhao, L.2    Xing, L.3    Chen, D.4
  • 90
    • 38549101581 scopus 로고    scopus 로고
    • Osteogenic differentiation of human adipose tissuederived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor
    • Luzi E, Marini F, Sala SC, Tognarini I, Galli G, Brandi ML. Osteogenic differentiation of human adipose tissuederived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor. J. Bone Miner. Res. 23(2), 287-295 (2008).
    • (2008) J. Bone Miner. Res. , vol.23 , Issue.2 , pp. 287-295
    • Luzi, E.1    Marini, F.2    Sala, S.C.3    Tognarini, I.4    Galli, G.5    Brandi, M.L.6
  • 91
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krützfeldt J, Rajewsky N, Braich R et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 438(7068), 685-689 (2005).
    • (2005) Nature , vol.438 , Issue.7068 , pp. 685-689
    • Krützfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 92
    • 33646715590 scopus 로고    scopus 로고
    • Improved targeting of miRNA with antisense oligonucleotides
    • Davis S, Lollo B, Freier S, Esau C. Improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res. 34(8), 2294-2304 (2006).
    • (2006) Nucleic Acids Res , vol.34 , Issue.8 , pp. 2294-2304
    • Davis, S.1    Lollo, B.2    Freier, S.3    Esau, C.4
  • 93
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells
    • Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat. Methods 4(9), 721-726 (2007).
    • (2007) Nat. Methods , vol.4 , Issue.9 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 94
    • 84863091299 scopus 로고    scopus 로고
    • MiRNA-140 is a negative feedback regulator of MMP-13 in IL-1b-stimulated human articular chondrocyte C28/I2 cells
    • Liang ZJ, Zhuang H, Wang GX et al. MiRNA-140 is a negative feedback regulator of MMP-13 in IL-1b-stimulated human articular chondrocyte C28/I2 cells. Inflamm. Res. 61(5), 503-509 (2012).
    • (2012) Inflamm. Res. , vol.61 , Issue.5 , pp. 503-509
    • Liang, Z.J.1    Zhuang, H.2    Wang, G.X.3
  • 95
    • 72849121740 scopus 로고    scopus 로고
    • A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans
    • Li H, Xie H, Liu W et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J. Clin. Invest. 119(12), 3666-3677 (2009).
    • (2009) J. Clin. Invest. , vol.119 , Issue.12 , pp. 3666-3677
    • Li, H.1    Xie, H.2    Liu, W.3
  • 96
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto D, Rossi JJ. The promises and pitfalls of RNA-interference- based therapeutics. Nature 457(7228), 426-433 (2009).
    • (2009) Nature , vol.457 , Issue.7228 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 97
    • 59849103061 scopus 로고    scopus 로고
    • Drug delivery of siRNA therapeutics: Potentials and limits of nanosystems
    • Reischl D, Zimmer A. Drug delivery of siRNA therapeutics: potentials and limits of nanosystems. Nanomedicine 5(1), 8-20 (2009).
    • (2009) Nanomedicine , vol.5 , Issue.1 , pp. 8-20
    • Reischl, D.1    Zimmer, A.2
  • 98
    • 68949208465 scopus 로고    scopus 로고
    • Nanocarriers' entry into the cell: Relevance to drug delivery
    • Hillaireau H, Couvreur P. Nanocarriers' entry into the cell: relevance to drug delivery. Cell. Mol. Life Sci. 66(17), 2873-2896 (2009).
    • (2009) Cell. Mol. Life Sci. , vol.66 , Issue.17 , pp. 2873-2896
    • Hillaireau, H.1    Couvreur, P.2
  • 99
    • 84863907494 scopus 로고    scopus 로고
    • Before and after Endosomal escape: Roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency
    • Kwon YJ. Before and after Endosomal escape: roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency. Acc. Chem. Res. 45(7), 1077-1088 (2012).
    • (2012) Acc. Chem. Res. , vol.45 , Issue.7 , pp. 1077-1088
    • Kwon, Y.J.1
  • 100
    • 84862777472 scopus 로고    scopus 로고
    • A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy
    • Zhang G, Guo B, Wu H et al. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat. Med. 18(2), 307-314 (2012).
    • (2012) Nat. Med. , vol.18 , Issue.2 , pp. 307-314
    • Zhang, G.1    Guo, B.2    Wu, H.3
  • 101
    • 53849106456 scopus 로고    scopus 로고
    • Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption
    • Sims NA, Gooi JH. Bone remodeling: multiple cellular interactions required for coupling of bone formation and resorption. Semin. Cell Dev. Biol. 19(5), 444-451 (2008).
    • (2008) Semin. Cell Dev. Biol. , vol.19 , Issue.5 , pp. 444-451
    • Sims, N.A.1    Gooi, J.H.2
  • 102
    • 33747031960 scopus 로고    scopus 로고
    • Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
    • McNamara JO 2nd, Andrechek ER, Wang Y et al. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat. Biotechnol. 24(8), 1005-1015 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , Issue.8 , pp. 1005-1015
    • McNamara II, J.O.1    Andrechek, E.R.2    Wang, Y.3
  • 103
    • 79951648921 scopus 로고    scopus 로고
    • Aptamer-conjugated nanomaterials for bioanalysis and biotechnology applications
    • Chen T, Shukoor MI, Chen Y et al. Aptamer-conjugated nanomaterials for bioanalysis and biotechnology applications. Nanoscale 3(2), 546-556 (2011).
    • (2011) Nanoscale , vol.3 , Issue.2 , pp. 546-556
    • Chen, T.1    Shukoor, M.I.2    Chen, Y.3
  • 104
    • 33748779821 scopus 로고    scopus 로고
    • Pegaptanib (Macugen): Treating neovascular age-related macular degeneration and current role in clinical practice
    • Vavvas D, D'Amico DJ. Pegaptanib (Macugen): treating neovascular age-related macular degeneration and current role in clinical practice. Ophthalmol. Clin. North Am. 19(3), 353-360 (2006).
    • (2006) Ophthalmol. Clin. North Am. , vol.19 , Issue.3 , pp. 353-360
    • Vavvas, D.1    D'Amico, D.J.2
  • 105
  • 106
    • 79952159933 scopus 로고    scopus 로고
    • Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signalling
    • Shum KT, Chan C, Leung CM, Tanner JA. Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signalling. Biochem. J. 434(3), 493-501 (2011).
    • (2011) Biochem. J. , vol.434 , Issue.3 , pp. 493-501
    • Shum, K.T.1    Chan, C.2    Leung, C.M.3    Tanner, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.