Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells

Clinical and Experimental Pharmacology and Physiology

Volumn 39, Issue 1, 2012, Pages 63-68

  Hong, Hong Jye ^a   Hsu, Feng Lin ^b   Tsai, Shih Chang ^a   Lin, Cheng Hsin ^c   Liu, Ju Chi ^a,c   Chen, Jin Jer ^a,d   Cheng, Tzu Hurng ^a   Chan, Paul ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Activating transcription factor 3; Cyclic strain; Endothelin 1; Nitric oxide; Tanshinone IIA; Traditional Chinese medicine

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ACTIVATING TRANSCRIPTION FACTOR; ENDOTHELIN 1; GUANYLATE CYCLASE INHIBITOR; NITRIC OXIDE; SMALL INTERFERING RNA; TANSHINONE IIA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 3; CARDIOVASCULAR DISEASES; CELLS, CULTURED; CELLULAR MICROENVIRONMENT; DITERPENES, ABIETANE; DOWN-REGULATION; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GUANYLATE CYCLASE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84855174216     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2011.05637.x     Document Type: Article

References (28)

1. Cheng TO. Danshen: A popular chinese cardiac herbal drug. J. Am. Coll. Cardiol. 2006; 47: 1498.
2. Cheng TO. Cardiovascular effects of Danshen. Int. J. Cardiol. 2007; 121: 9-22.
3. Hong HJ, Liu JC, Cheng TH, Chan P. Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes. Acta Pharmacol. Sin. 2010; 31: 1569-75.
4. Hong HJ, Liu JC, Chen PY et al. Tanshinone IIA prevents doxorubicin-induced cardiomyocyte apoptosis through Akt-dependent pathway. Int. J. Cardiol. 2010; Epub 24 December 2010; doi:.
5. Kim DD, Sanchez FA, Duran RG et al. Endothelial nitric oxide synthase is a molecular vascular target for the Chinese herb Danshen in hypertension. Am. J. Physiol. Heart Circ. Physiol. 2007; 292: H2131-7.
6. Wan AK, Leung SW, Zhu DY, Man RY. Vascular effects of different lipophilic components of 'Danshen', a traditional Chinese medicine, in the isolated porcine coronary artery. J. Nat. Prod. 2008; 71: 1825-8.
7. Sessa WC. Molecular control of blood flow and angiogenesis: Role of nitric oxide. J. Thromb. Haemost. 2009; 7 (Suppl. 1): 35-7.
8. Cerra MC, Pellegrino D. Cardiovascular cGMP-generating systems in physiological and pathological conditions. Curr. Med. Chem. 2007; 14: 585-99.
9. Thorin E, Webb DJ. Endothelium-derived endothelin-1. Pflügers Arch. 2010; 459: 951-8.
10. Balligand JL, Feron O, Dessy C. eNOS activation by physical forces: From short-term regulation of contraction to chronic remodeling of cardiovascular tissues. Physiol. Rev. 2009; 89: 481-534.
11. Schiffrin EL. Role of endothelin-1 in hypertension and vascular disease. Am. J. Hypertens. 2001; 14 (Suppl.): S83-9.
12. Cheng TH, Shih NL, Chen SY et al. Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells. J. Mol. Cell. Cardiol. 2001; 33: 1805-14.
13. Hashimoto Y, Zhang C, Kawauchi J et al. An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. Nucleic Acids Res. 2002; 30: 2398-406.
14. Gilchrist M, Thorsson V, Li B et al. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 2006; 441: 173-8.
15. Chen HH, Wang DL. Nitric oxide inhibits matrix metalloproteinase-2 expression via the induction of activating transcription factor 3 in endothelial cells. Mol. Pharmacol. 2004; 65: 1130-40.
16. Reiter CE, Kim JA, Quon MJ. Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells. Roles for AMP-activated protein kinase, Akt, and FOXO1. Endocrinology 2010; 151: 103-14.
17. Cheng TH, Chen JJ, Chen CH, Wong KL. Effects of propofol on cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells. Anesthesiology 2009; 110: 74-80.
18. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: Structure, function and inhibition. Biochem. J. 2001; 357: 593-615.
19. Hai T, Wolfgang CD, Marsee DK et al. ATF3 and stress responses. Gene Expr. 1999; 7: 321-35.
20. Dimmeler S, Zeiher AM. Nitric oxide: An endothelial cell survival factor. Cell Death Differ. 1999; 6: 964-8.
21. Kawauchi J, Zhang C, Nobori K et al. Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription. J. Biol. Chem. 2002; 277: 39.
22. Mashima T, Udagawa S, Tsuruo T. Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis. J. Cell. Physiol. 2001; 188: 352-8.
23. Chen BP, Wolfgang CD, Hai T. Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol. Cell. Biol. 1996; 16: 1157-68.
24. Hai T, Hartman MG. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors. Activating transcription factor proteins and homeostasis. Gene 2001; 273: 1-11.
25. Cheng CM, Hong HJ, Liu JC et al. Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts. Mol. Pharmacol. 2004; 63: 1002-11.
26. Hsu JC, Bravo R, Taub R. Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration. Mol. Cell. Biol. 1992; 12: 4654-65.
27. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601-5.
28. Gewaltig MT, Kojda G. Vasoprotection by nitric oxide: Mechanisms and therapeutic potential. Cardiovasc. Res. 2002; 55: 250-60.