Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 298, Issue 2, 2010, Pages

  Vanzela, E C ^a   Ribeiro, R A ^a   De Oliveira, C A Machado ^a   Rodrigues, F B ^a   Bonfleur, M L ^a   Carneiro, E M ^a   Souza, K L A ^a   Boschero, A C ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Ca2+; Insulin resistance; Metabolic syndrome; Metabolism; Pancreatic cells

Indexed keywords

CALCIUM; GLUCOSE; INSULIN; MESSENGER RNA; POTASSIUM CHLORIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TOLBUTAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GLUCOSE OXIDATION; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET; PREGNANCY; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SHAM FEEDING;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CALCIUM; CALCIUM CHANNELS; DIET; DNA; FEMALE; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; LIPIDS; OBESITY; ORGAN SIZE; OXIDATION-REDUCTION; POTASSIUM CHLORIDE; PREGNANCY; PREGNANCY, ANIMAL; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TOLBUTAMIDE;

EID: 75449119458     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00256.2009     Document Type: Article

References (37)

1. Amaral ME, Cunha DA, Anhe GF, Ueno M, Carneiro EM, Velloso LA, Bordin S, Boschero AC. Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy. J Endocrinol 183: 469-476, 2004.
2. 2+-ATPase 2 expression by prolactin and glucocorticoids is involved in the adaptation of insulin secretory response during the peripartum period. J Endocrinol 195: 17-27, 2007.
3. Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care 30 Suppl 2: S112-S119, 2007.
4. Bonadonna RC, Groop L, Kraemer N, Ferrannini E, Del Prato S, DeFronzo RA. Obesity and insulin resistance in humans: a dose-response study. Metabolism 39: 452-459, 1990.
5. Bordin S, Amaral ME, Anhe GF, Delghingaro-Augusto V, Cunha DA, Nicoletti-Carvalho JE, Boschero AC. Prolactin-modulated gene expression profiles in pancreatic islets from adult female rats. Mol Cell Endocrinol 220: 41-50, 2004.
6. Brelje TC, Scharp DW, Lacy PE, Ogren L, Talamantes F, Robertson M, Friesen HG, Sorenson RL. Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy. Endocrinology 132: 879-887, 1993.
7. Caterson ID, Gill TP. Obesity: epidemiology and possible prevention. Best Pract Res Clin Endocrinol Metab 16: 595-610, 2002.
8. Cunha DA, Amaral ME, Carvalho CP, Collares-Buzato CB, Carneiro EM, Boschero AC. Increased expression of SNARE proteins and synaptotagmin IV in islets from pregnant rats and in vitro prolactin-treated neonatal islets. Biol Res 39: 555-566, 2006.
9. De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, Saad MJ, Velloso LA. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146: 4192-4199, 2005.
10. Devlieger R, Casteels K, Van Assche FA. Reduced adaptation of the pancreatic B cells during pregnancy is the major causal factor for gestational diabetes: Current knowledge and metabolic effects on the offspring. Acta Obstet Gynecol Scand 1-5, 2008.
11. Di Cianni G, Seghieri G, Lencioni C, Cuccuru I, Anichini R, De Bellis A, Ghio A, Tesi F, Volpe L, Del Prato S. Normal glucose tolerance and gestational diabetes mellitus: what is in between? Diabetes Care 30: 1783-1788, 2007.
12. Douglas WW, Rubin RP. The role of calcium in the secretory response of the adrenal medulla to acetylcholine. J Physiol 159: 40-57, 1961.
13. Flegal KM, Graubard BI, Williamson DF, Gail MH. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA 298: 2028-2037, 2007.
14. Hedeskov CJ, Capito K, Thams P. Cytosolic ratios of free [NADPH]/ [NADP+] and [NADH]/[NAD+] in mouse pancreatic islets, and nutrientinduced insulin secretion. Biochem J 241: 161-167, 1987.
15. Holness MJ, Smith ND, Greenwood GK, Sugden MC. PPARα activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy. Am J Physiol Endocrinol Metab 292: E1087-E1094, 2007.
16. Kissebah AH. Insulin resistance in visceral obesity. Int J Obes 15 Suppl 2: 109-115, 1991.
17. 2+-ATPase (SERCA)-2b and -3. Diabetes 53: 1517-1525, 2004.
18. Leturque A, Ferre P, Satabin P, Kervran A, Girard J. In vivo insulin resistance during pregnancy in the rat. Diabetologia 19: 521-528, 1980.
19. Malaisse WJ, Malaisse-Lagae F, Picard C, Flament-Durand J. Effects of pregnancy and chorionic growth hormone upon insulin secretion. Endocrinology 84: 41-44, 1969.
20. Malaisse WJ, Sener A, Herchuelz A, Hutton JC. Insulin release: the fuel hypothesis. Metabolism 28: 373-386, 1979.
21. 2+ handling in islets of GK and nSTZ rat models of type 2 diabetes. J Endocrinol 169: 169-176, 2001.
22. Martyn JA, Kaneki M, Yasuhara S. Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms. Anesthesiology 109: 137-148, 2008.
23. Parsons JA, Brelje TC, Sorenson RL. Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 130: 1459-1466, 1992.
24. Polonsky KS, Given BD, Van Cauter E. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest 81: 442-448, 1988.
25. Prada PO, Zecchin HG, Gasparetti AL, Torsoni MA, Ueno M, Hirata AE, Corezola do Amaral ME, Hoer NF, Boschero AC, Saad MJ. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology 146: 1576-1587, 2005.
26. Reinbothe TM, Ivarsson R, Li DQ, Niazi O, Jing X, Zhang E, Stenson L, Bryborn U, Renstrom E. Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion. Mol Endocrinol 23: 893-900, 2009.
27. Rothwell NJ, Stock MJ. Regulation of energy balance in two models of reversible obesity in the rat. J Comp Physiol Psychol 93: 1024-1034, 1979.
28. Sclafani A, Springer D. Dietary obesity in adult rats: similarities to hypothalamic and human obesity syndromes. Physiol Behav 17: 461-471, 1976.
29. Segu VB, Li G, Metz SA. Use of a soluble tetrazolium compound to assay metabolic activation of intact β cells. Metabolism 47: 824-830, 1998.
30. Sorenson RL, Brelje TC. Adaptation of islets of Langerhans to pregnancy: β-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 29: 301-307, 1997.
31. Takahashi RF, Curi R, Carpinelli AR. Insulin secretion to glucose stimulus in pancreatic islets isolated from rats fed unbalanced diets. Physiol Behav 50: 787-791, 1991.
32. Tengholm A, Gylfe E. Oscillatory control of insulin secretion. Mol Cell Endocrinol 297: 58-72, 2009.
33. Weinhaus AJ, Stout LE, Bhagroo NV, Brelje TC, Sorenson RL. Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy. J Endocrinol 193: 367-381, 2007.
34. Weinhaus AJ, Stout LE, Sorenson RL. Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: mechanisms for long-term up-regulation of islets. Endocrinology 137: 1640 -1649, 1996.
35. West DB, York B. Dietary fat, genetic predisposition, and obesity: lessons from animal models. Am J Clin Nutr 67: 505S-512S, 1998.
36. Woods SC, D'Alessio DA, Tso P, Rushing PA, Clegg DJ, Benoit SC, Gotoh K, Liu M, Seeley RJ. Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiol Behav 83: 573-578, 2004.
37. Ying W. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal 10: 179 -206, 2008.