Cytochrome P4502C11 is a target of diclofenac covalent binding in rats

Chemical Research in Toxicology

Volumn 10, Issue 4, 1997, Pages 420-423

  Shen, Sijiu ^a   Hargus, Sally J ^a,c   Martin, Brian M ^b   Pohl, Lance R ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c 3M COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 ISOENZYME; DICLOFENAC; DRUG ANTIBODY; DRUG METABOLITE; GLUTATHIONE; LYSINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVITY; ENZYME MODIFICATION; ENZYME PURIFICATION; ENZYME STRUCTURE; FEMALE; LIVER MICROSOME; LIVER TOXICITY; MALE; NONHUMAN; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; ENZYME INHIBITORS; FEMALE; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0030992926     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960167z     Document Type: Article

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