Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites

Chemical Research in Toxicology

Volumn 24, Issue 8, 2011, Pages 1263-1274

  Boerma, J S ^a   Vermeulen, N P E ^a   Commandeur, J N M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; CYTOCHROME P450 BM3; DRUG METABOLITE; GLUTATHIONE TRANSFERASE P1; IMINE; N ACETYL 4 BENZOQUINONE IMINE; PARACETAMOL; QUINONE DERIVATIVE; TROGLITAZONE; UNCLASSIFIED DRUG;

ARTICLE; LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

ACETAMINOPHEN; BACTERIAL PROTEINS; CHROMANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOZAPINE; CYSTEINE; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE TRANSFERASE; HUMANS; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; PEPTIDES; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; TANDEM MASS SPECTROMETRY; THIAZOLIDINEDIONES; TRYPSIN;

EID: 80051761925     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx2001515     Document Type: Article

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