Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling

Journal of Biological Chemistry

Volumn 287, Issue 47, 2012, Pages 39942-39953

  Fujita, Nobuyuki ^a,b   Gogate, Shilpa S ^a   Chiba, Kazuhiro ^c   Toyama, Yoshiaki ^b   Shapiro, Irving M ^a   Risbud, Makarand V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b KEIO UNIVERSITY   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CO-ACTIVATION; CYTOKINES; DEGENERATIVE DISC DISEASE; HYDROXYLASES; HYPOXIA RESPONSE ELEMENTS; HYPOXIA-INDUCIBLE FACTORS; INFLAMMATORY CONDITIONS; INFLAMMATORY CYTOKINES; ISOFORMS; MECHANISTIC STUDIES; NUCLEAR FACTORS; NUCLEUS PULPOSUS; PROLYL HYDROXYLASE; SIGNALING ACTIVITY; TUMOR NECROSIS FACTORS; TYPE II;

CELLS; CHEMICAL ACTIVATION; GENE EXPRESSION; GLYCOPROTEINS;

CYTOLOGY;

AGGRECAN; AGGRECANASE 2; COLLAGEN TYPE 2; COLLAGENASE 3; CYCLOOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LENTIVIRUS VECTOR; OXYGENASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE 3; SYNAPTOTAGMIN I; SYNDECAN 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATABOLISM; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ADAM PROTEINS; ANIMALS; CELLS, CULTURED; COLLAGEN TYPE II; CYCLOOXYGENASE 2; DIOXYGENASES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MATRIX METALLOPROTEINASE 13; RATS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; SYNDECAN-4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84869203441     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.375964     Document Type: Article

References (30)

1. Gruber, H. E., Ashraf, N., Kilburn, J., Williams, C., Norton, H. J., Gordon, B. E., and Hanley, E. N. (2005) Vertebral endplate architecture and vascularization. Application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the ageing sand rat. Spine 30, 2593-2600 (Pubitemid 41780368)
2. Hassler, O. (1969) The human intervertebral disc. A microangiographical study on its vascular supply at various ages. Acta Orthop. Scand. 40, 765-772
3. Rudert, M., and Tillmann, B. (1993) Lymph and blood supply of the human intervertebral disc. Cadaver studies of correlations to discitis. Acta Orthop. Scand. 64, 37-40 (Pubitemid 23092299)
4. Bartels, E. M., Fairbank, J. C., Winlove, C. P., and Urban, J. P. (1998) Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine 23, 1-7; discussion 8
5. Fujita, N., Markova, D., Anderson, D. G., Chiba, K., Toyama, Y., Shapiro, I. M., and Risbud, M. V. (2012) Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia. J. Biol. Chem. 287, 16975-16986
6. Fujita, N., Chiba, K., Shapiro, I. M., and Risbud, M. V. (2012) HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. J. Bone Miner. Res. 27, 401-412
7. Saito, T., Fukai, A., Mabuchi, A., Ikeda, T., Yano, F., Ohba, S., Nishida, N., Akune, T., Yoshimura, N., Nakagawa, T., Nakamura, K., Tokunaga, K., Chung, U. I., and Kawaguchi, H. (2010) Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development. Nat. Med. 16, 678-686
8. Yang, S., Kim, J., Ryu, J. H., Oh, H., Chun, C. H., Kim, B. J., Min, B. H., and Chun, J. S. (2010) Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction. Nat. Med. 16, 687-693
9. Shamji, M. F., Setton, L. A., Jarvis, W., So, S., Chen, J., Jing, L., Bullock, R., Isaacs, R. E., Brown, C., and Richardson, W. J. (2010) Proinflammatory cytokine expression in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum. 62, 1974-1982
10. Weiler, C., Nerlich, A. G., Bachmeier, B. E., and Boos, N. (2005) Expression and distribution of tumor necrosis factor α in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 30, 44-53; discussion 54
11. Le Maitre, C. L., Freemont, A. J., and Hoyland, J. A. (2005) The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res. Ther. 7, R732-R745
12. Séguin, C. A., Pilliar, R. M., Roughley, P. J., and Kandel, R. A. (2005) Tumor necrosis factor-α modulates matrix production and catabolism in nucleus pulposus tissue. Spine 30, 1940-1948 (Pubitemid 41292217)
13. Lee, J. M., Song, J. Y., Baek, M., Jung, H. Y., Kang, H., Han, I. B., Kwon, Y. D., and Shin, D. E. (2011) Interleukin-1β induces angiogenesis and innervation in human intervertebral disc degeneration. J. Orthop. Res. 29, 265-269
14. Wang, J., Markova, D., Anderson, D. G., Zheng, Z., Shapiro, I. M., and Risbud, M. V. (2011) TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thromobospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J. Biol. Chem. 286, 39738-39749
15. Johansen, J. L., Sager, T. N., Lotharius, J., Witten, L., Mørk, A., Egebjerg, J., and Thirstrup, K. (2010) HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells. J. Neurochem. 115, 209-219
16. Yeramian, A., Santacana, M., Sorolla, A., Llobet, D., Encinas, M., Velasco, A., Bahi, N., Eritja, N., Domingo, M., Oliva, E., Dolcet, X., and Matias-Guiu, X. (2011) Nuclear factor-κB2/p100 promotes endometrial carcinoma cell survival under hypoxia in a HIF-1α-independent manner. Lab. Invest. 91, 859-871
17. Fu, J., and Taubman, M. B. (2010) Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-κB-dependent pathway. J. Biol. Chem. 285, 8927-8935
18. Pescador, N., Cuevas, Y., Naranjo, S., Alcaide, M., Villar, D., Landázuri, M. O., and Del Peso, L. (2005) Identification of a functional hypoxiaresponsive element that regulates the expression of the EGL nine homologue 3 (egln3/phd3) gene. Biochem. J. 390, 189-197 (Pubitemid 41192244)
19. Risbud, M. V., Guttapalli, A., Stokes, D. G., Hawkins, D., Danielson, K. G., Schaer, T. P., Albert, T. J., and Shapiro, I. M. (2006) Nucleus pulposus cells express HIF-1 α under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. J. Cell Biochem. 98, 152-159
20. Pfirrmann, C. W., Metzdorf, A., Zanetti, M., Hodler, J., and Boos, N. (2001) Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 26, 1873-1878 (Pubitemid 32844681)
21. Metzen, E., Stiehl, D. P., Doege, K., Marxsen, J. H., Hellwig-Bürgel, T., and Jelkmann, W. (2005) Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene. Identification of a functional hypoxia-responsive element. Biochem. J. 387, 711-717 (Pubitemid 40685705)
22. D'Angelo, G., Duplan, E., Boyer, N., Vigne, P., and Frelin, C. (2003) Hypoxia up-regulates prolyl hydroxylase activity. A feedback mechanism that limits HIF-1 responses during reoxygenation. J. Biol. Chem. 278, 38183-38187 (Pubitemid 37221706)
23. Marxsen, J. H., Stengel, P., Doege, K., Heikkinen, P., Jokilehto, T., Wagner, T., Jelkmann, W., Jaakkola, P., and Metzen, E. (2004) Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4- hydroxylases. Biochem. J. 381, 761-767 (Pubitemid 39120486)
24. Jung, Y. J., Isaacs, J. S., Lee, S., Trepel, J., and Neckers, L. (2003) IL-1β-mediated up-regulation of HIF-1α via an NFκB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 17, 2115-2117
25. van Uden, P., Kenneth, N. S., and Rocha, S. (2008) Regulation of hypoxia-inducible factor-1α by NF-κB. Biochem. J. 412, 477-484
26. Nam, S. Y., Ko, Y. S., Jung, J., Yoon, J., Kim, Y. H., Choi, Y. J., Park, J. W., Chang, M. S., Kim, W. H., and Lee, B. L. (2011) A hypoxia-dependent up-regulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumor growth and angiogenesis. Br. J. Cancer 104, 166-174
27. Wasserman, W. W., and Sandelin, A. (2004) Applied bioinformatics for the identification of regulatory elements. Nat. Rev. Genet. 5, 276-287 (Pubitemid 38435623)
28. Luo, W., Hu, H., Chang, R., Zhong, J., Knabel, M., O'Meally, R., Cole, R. N., Pandey, A., and Semenza, G. L. (2011) Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145, 732-744
29. Xue, J., Li, X., Jiao, S., Wei, Y., Wu, G., and Fang, J. (2010) Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKβ independent of hydroxylase activity. Gastroenterology 138, 606-615
30. Séguin, C. A., Bojarski, M., Pilliar, R. M., Roughley, P. J., and Kandel R. A. (2006) Differential regulation of matrix degrading enzymes in a TNF-α-induced model of nucleus pulposus tissue degeneration. Matrix Biol. 25, 409-418 (Pubitemid 44512122)