Molecular, cellular, and structural mechanisms of cocaine addiction: A key role for MicroRNAs

Neuropsychopharmacology

Volumn 38, Issue 1, 2013, Pages 198-211

  Jonkman, Sietse ^a   Kenny, Paul J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

BDNF; cocaine; CREB; MeCP2; microRNAs; miR 132; miR 212

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; COCAINE; METHYL CPG BINDING PROTEIN 2; MICRORNA; PHOSPHOPROTEIN DARPP 32;

COCAINE DEPENDENCE; CORPUS STRIATUM; DRUG SEEKING BEHAVIOR; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC REGULATION; HUMAN; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REINFORCEMENT; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; COCAINE; COCAINE-RELATED DISORDERS; HUMANS; MICRORNAS; NEURONAL PLASTICITY; REWARD; SELF ADMINISTRATION;

EID: 84869079253     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2012.120     Document Type: Review

References (136)

1. Abuhatzira L, Makedonski K, Kaufman Y, Razin A, Shemer R (2007). MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production. Epigenetics 2: 214-222.
2. Acar M, Becskei A, van Oudenaarden A (2005). Enhancement of cellular memory by reducing stochastic transitions. Nature 435: 228-232.
3. Ahmed SH (2005). Imbalance between drug and non-drug reward availability: a major risk factor for addiction. Eur J Pharmacol 526: 9-20.
4. Ahmed SH, Kenny PJ, Koob GF, Markou A (2002). Neurobiological evidence for hedonic allostasis associated with escalating cocaine use. Nat Neurosci 5: 625-626.
5. Ahmed SH, Koob GF (1998). Transition from moderate to excessive drug intake: change in hedonic set point. Science 282: 298-300.
6. Ahmed SH, Koob GF (2005). Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function. Psychopharmacology (Berl) 180: 473-490.
7. Ahmed SH, Walker JR, Koob GF (2000). Persistent increase in the motivation to take heroin in rats with a history of drug escalation. Neuropsychopharmacology 22: 413-421.
8. Altar CA, Cai N, Bliven T, Juhasz M, Conner JM, Acheson AL et al (1997). Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 389: 856-860.
9. Altarejos JY, Goebel N, Conkright MD, Inoue H, Xie J, Arias CM et al (2008). The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med 14: 1112-1117.
10. American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders: DSM-IV (4th ed.). American Psychiatric Association: Washington, DC.
11. Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY (1999). Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpGbinding protein 2. Nat Genet 23: 185-188.
12. Ang E, Chen J, Zagouras P, Magna H, Holland J, Schaeffer E et al (2001). Induction of nuclear factor-kB in nucleus accumbens by chronic cocaine administration. J Neurochem 79: 221-224.
13. Anthony JC, Warner LA, Kessler RC (1994). Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the national comorbidity survey. Exp Clin Psychopharmacol 2: 244-268.
14. Barak Caine S, Heinrichs SC, Coffin VL, Koob GF (1995). Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain Res 692: 47-56.
15. Bartel DP (2009). MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
16. Bateup HS, Svenningsson P, Kuroiwa M, Gong S, Nishi A, Heintz N et al (2008). Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs. Nat Neurosci 11: 932-939.
17. Bertran-Gonzalez J, Bosch C, Maroteaux M, Matamales M, Hervé D, Valjent E et al (2008). Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. J Neurosci 28: 5671-5685.
18. Bibb JA, Chen J, Taylor JR, Svenningsson P, Nishi A, Snyder GL et al (2001). Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature 410: 376-380.
19. Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA et al (1999). Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature 402: 669-671.
20. Bozarth MA, Wise RA (1985). Toxicity associated with long-term intravenous heroin and cocaine self-administration in the rat. JAMA 254: 81-83.
21. Carlezon Jr WA, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N et al (1998). Regulation of cocaine reward by CREB. Science 282: 2272-2275.
22. Cartwright WS (2000). Cocaine medications, cocaine consumption and societal costs. Pharmacoeconomics 18: 405-413.
23. Cassel S, Carouge D, Gensburger C, Anglard P, Burgun C, Dietrich JB et al (2006). Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Mol Pharmacol 70: 487-492.
24. Caulkins JP, Pacula RL, Paddock SM, Chiesa J (2002). School-based drug prevention: what kind of drug use does it prevent. MR-1427-CAE. RAND, Santa monica.
25. Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J et al (2008). MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320: 1224-1229.
26. Chandrasekar V, Dreyer J-L (2009). MicroRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity. Mol Cell Neurosci 42: 350-362.
27. Chandrasekar V, Dreyer J-L (2011). Regulation of MiR-124, Let-7d, and MiR-181a in the accumbens affects the expression, extinction, and reinstatement of cocaine-induced conditioned place preference. Neuropsychopharmacology 36: 1149-1164.
28. Chang Q, Khare G, Dani V, Nelson S, Jaenisch R (2006). The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49: 341-348.
29. Colby CR, Whisler K, Steffen C, Nestler EJ, Self DW (2003). Striatal cell typespecific overexpression of DFosB enhances incentive for cocaine. J Neurosci 23: 2488-2493.
30. Cole RL, Konradi C, Douglass J, Hyman SE (1995). Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14: 813-823.
31. Covington III HE, Maze I, Sun H, Bomze Howard M, DeMaio Kristine D, Wu Emma Y et al (2011). A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron 71: 656-670.
32. Criswell HE, Ridings A (1983). Intravenous self-administration of morphine by naive mice. Pharmacol Biochem Behav 18: 467-470.
33. Decorte T (2001). Drug users' perceptions of 'controlled' and 'uncontrolled' use. Int J Drug Pol 12: 297-320.
34. Deng Y-P, Lei W-L, Reiner A (2006). Differential perikaryal localization in rats of D1 and D2 dopamine receptors on striatal projection neuron types identified by retrograde labeling. J Chem Neuroanat 32: 101-116.
35. Deroche-Gamonet V, Belin D, Piazza PV (2004). Evidence for addiction-like behavior in the rat. Science 305: 1014-1017.
36. Di Chiara G, Imperato A (1988). Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci 85: 5274-5278.
37. Dinieri JA, Nemeth CL, Parsegian A, Carle T, Gurevich VV, Gurevich E et al (2009). Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. J Neurosci 29: 1855-1859.
38. Donny EC, Caggiula AR, Knopf S, Brown C (1995). Nicotine self-administration in rats. Psychopharmacology (Berl) 122: 390-394.
39. Eipper-Mains JE, Kiraly DD, Palakodeti D, Mains RE, Eipper BA, Graveley BR (2011). MicroRNA-Seq reveals cocaine-regulated expression of striatal micro-RNAs. RNA 17: 1529-1543.
40. Everitt BJ, Robbins TW (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8: 1481-1489.
41. Fernandez E, Schiappa R, Girault JA, Le Novere N (2006). DARPP-32 is a robust integrator of dopamine and glutamate signals. PLoS Comput Biol 2: e176.
42. Ferri CP, Gossop M, Laranjeira RR (2001). High dose cocaine use in Sao Paulo: a comparison of treatment and community samples. Subst Use Misuse 36: 237-255.
43. Fienberg AA, Hiroi N, Mermelstein PG, Song W-J, Snyder GL, Nishi A et al (1998). DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science 281: 838-842.
44. Freeman AY, Soghomonian JJ, Pierce RC (2003). Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. Neuroscience 117: 147-156.
45. Fuchs RA, Evans KA, Parker MC, See RE (2004). Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology 176: 459-465.
46. Gawin FH, Ellinwood Jr EH (1989). Cocaine dependence. Annu Rev Med 40: 149-161.
47. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996). Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379: 606-612.
48. Gonon F (1997) Prolonged and extrasynaptic excitatory action of dopamine mediated by D1 receptors in the rat striatum in vivo. J Neurosci 17: 5972-5978.
49. Gonzalez GA, Montminy MR (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59: 675-680.
50. Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M, Self DW (2007). Dynamic BDNF activity in nucleus accumbens with cocaine use increases selfadministration and relapse. Nat Neurosci 10: 1029-1037.
51. Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK et al (2009). Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry 65: 696-701.
52. Griffiths RR, Balster RL (1979). Opioids: similarity between evaluations of subjective effects and animal self-administration results. Clin Pharmacol Ther 25(Part 1): 611-617.
53. Griffiths RR, Brady JV, Bigelow GE (1981). Predicting the dependence liability of stimulant drugs. NIDA Res Monogr 37: 182-196.
54. Grimm JW, Lu L, Hayashi T, Hope BT, Su TP, Shaham Y (2003). Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J Neurosci 23: 742-747.
55. Hasbi A, Fan T, Alijaniaram M, Nguyen T, Perreault ML, O'Dowd BF et al (2009). Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth. Proc Natl Acad Sci 106: 21377-21382.
56. Hayaki J, Anderson BJ, Stein MD (2008). Drug use expectancies among nonabstinent community cocaine users. Drug Alcohol Dependence 94: 109-115.
57. Herve D (2011). Identification of a specific assembly of the G protein Golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatum. Front Neuroanat 5: 1-9.
58. Hiroi N, Fienberg AA, Haile CN, Alburges M, Hanson GR, Greengard P et al (1999). Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice. Eur J Neurosci 11: 1114-1118.
59. Hollander JA, Im H-I, Amelio AL, Kocerha J, Bali P, Lu Q et al (2010). Striatal microRNA controls cocaine intake through CREB signalling. Nature 466: 197-202.
60. Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, Nakabeppu Y et al (1994). Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13: 1235-1244.
61. Horger BA, Iyasere CA, Berhow MT, Messer CJ, Nestler EJ, Taylor JR (1999). Enhancement of locomotor activity and conditioned reward to cocaine by brainderived neurotrophic factor. J Neurosci 19: 4110-4122.
62. Ikemoto S (2003) Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. J Neurosci 23: 9305-9311.
63. Im H-I, Hollander JA, Bali P, Kenny PJ (2010) MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Nat Neurosci 13: 1120-1127.
64. Im HI, Kenny PJ (2012). MicroRNAs in neuronal function and dysfunction. Trends Neurosci 35: 325-334.
65. Inoue D, Kido S, Matsumoto T (2004). Transcriptional induction of FosB/DFosB gene by mechanical stress in osteoblasts. J Biol Chem 279: 49795-49803.
66. Institute for Health Policy (2001). Substance Abuse: The Nation's Number One Health Problem. Brandies University: Waltham, MA.
67. Ito R, Robbins TW, Everitt BJ (2004). Differential control over cocaine-seeking behavior by nucleus accumbens core and shell. Nat Neurosci 7: 389-397.
68. John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS (2004). Human microRNA targets. PLoS Biol 2: e363.
69. Jonkman S, Pelloux Y, Everitt BJ (2012a). Differential roles of the dorsolateral and midlateral striatum in punished cocaine seeking. J Neurosci 32: 4645-4650.
70. Jonkman S, Pelloux Y, Everitt BJ (2012b). Drug intake is sufficient, but conditioning is not necessary for the emergence of compulsive cocaine seeking after extended self-administration. Neuropsychopharmacology 37: 1612-1619.
71. Kano T, Suzuki Y, Shibuya M, Kiuchi K, Hagiwara M (1995). Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice. NeuroReport 6: 2197-2200.
72. Kelz MB, Chen J, Carlezon WA, Whisler K, Gilden L, Beckmann AM et al (1999). Expression of the transcription factor [Delta]FosB in the brain controls sensitivity to cocaine. Nature 401: 272-276.
73. Kenny PJ (2007). Brain reward systems and compulsive drug use. Trends Pharmacol Sci 28: 135-141.
74. Kitamura O, Wee S, Specio SE, Koob GF, Pulvirenti L (2006). Escalation of methamphetamine self-administration in rats: a dose-effect function. Psychopharmacology (Berl) 186: 48-53.
75. Klein ME, Lioy DT, Ma L, Impey S, Mandel G, Goodman RH (2007). Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci 10: 1513-1514.
76. Kondo M, Gray LJ, Pelka GJ, Christodoulou J, Tam PP, Hannan AJ (2008). Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndromeFMecp2 gene dosage effects and BDNF expression. Eur J Neurosci 27: 3342-3350.
77. Kovacs KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O et al (2007). TORC1 is a calcium-and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity. Proc Natl Acad Sci USA 104: 4700-4705.
78. Kramer JC, Fischman VS, Littlefield DC (1967). Amphetamine abuse. Pattern and effects of high doses taken intravenously. JAMA 201: 305-309.
79. Kreek MJ, LaForge KS, Butelman E (2002). Pharmacotherapy of addictions. Nat Rev Drug Discov 1: 710-726.
80. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A et al (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129: 1401-1414.
81. Larimore JL, Chapleau CA, Kudo S, Theibert A, Percy AK, Pozzo-Miller L (2009). Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations. Neurobiol Dis 34: 199-211.
82. Larson EB, Graham DL, Arzaga RR, Buzin N, Webb J, Green TA et al (2011). Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. J Neurosci 31: 16447-16457.
83. Lee K-W, Kim Y, Kim AM, Helmin K, Nairn AC, Greengard P (2006). Cocaineinduced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. Proc Natl Acad Sci USA 103: 3399-3404.
84. Levine AA, Guan Z, Barco A, Xu S, Kandel ER, Schwartz JH (2005). CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Proc Natl Acad Sci USA 102: 19186-19191.
85. Li S, Zhang C, Takemori H, Zhou Y, Xiong ZQ (2009). TORC1 regulates activitydependent CREB-target gene transcription and dendritic growth of developing cortical neurons. J Neurosci 29: 2334-2343.
86. Lingel A, Simon B, Izaurralde E, Sattler M (2003). Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature 426: 465-469.
87. Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S et al (2008). A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273.
88. Lobo MK, Covington III HE, Chaudhury D, Friedman AK, Sun H, Damez-Werno D et al (2010). Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330: 385-390.
89. Lonze BE, Ginty DD (2002). Function and regulation of CREB family transcription factors in the nervous system. Neuron 35: 605-623.
90. Lu L, Dempsey J, Liu SY, Bossert JM, Shaham Y (2004). A single infusion of brainderived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal. J Neurosci 24: 1604-1611.
91. Lu L, Hope BT, Dempsey J, Liu SY, Bossert JM, Shaham Y (2005). Central amygdala ERK signaling pathway is critical to incubation of cocaine craving. Nat Neurosci 8: 212-219.
92. Luscher C, Malenka RC (2011). Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron 69: 650-663.
93. Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ et al (2010). Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327: 213-216.
94. McClung CA, Nestler EJ (2003) Regulation of gene expression and cocaine reward by CREB and [Delta]FosB. Nat Neurosci 6: 1208-1215.
95. Mumola CJ, Karberg JC (2006) US Drug use and dependence, state and federal prisoners, 2004. US Department of Justice, Office of Justice Programs, Washington, DC.
96. Mutschler NH, Miczek KA (1998). Withdrawal from IV cocaine 'binges' in rats: ultrasonic distress calls and startle. Psychopharmacology 135: 161-168.
97. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN et al (1998). Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393: 386-389.
98. Nestler EJ, Barrot M, Self DW (2001). DeltaFosB: a sustained molecular switch for addiction. Proc Natl Acad Sci USA 98: 11042-11046.
99. Nishi A, Snyder GL, Greengard P (1997). Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J Neurosci 17: 8147-8155.
100. O'Brien CP (1997). A range of research-based pharmacotherapies for addiction. Science 278: 66-70.
101. Pickens R, Thompson T (1968). Cocaine-reinforced behavior in rats: effects of reinforcement magnitude and fixed-ratio size. J Pharmacol Exp Therap 161: 122-129.
102. Pontieri FE, Tanda G, Di Chiara G (1995). Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the 'shell' as compared with the 'core' of the rat nucleus accumbens. Proc Natl Acad Sci 92: 12304-12308.
103. Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A et al (2008). Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59: 621-633.
104. Renthal W, Kumar A, Xiao G, Wilkinson M, Covington III HE, Maze I et al (2009). Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron 62: 335-348.
105. Ridenour TA, Lanza ST, Donny EC, Clark DB (2006). Different lengths of times for progressions in adolescent substance involvement. Addict Behav 31: 962-983.
106. Risner ME, Jones BE (1975). Self-administration of CNS stimulants by dog. Psychopharmacologia 43: 207-213.
107. Russo SJ, Wilkinson MB, Mazei-Robison MS, Dietz DM, Maze I, Krishnan V et al (2009). Nuclear factor kB signaling regulates neuronal morphology and cocaine reward. J Neurosci 29: 3529-3537.
108. Schaefer A, Im H-I, Ven MT, Fowler CD, Min A, Intrator A et al (2010). Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. J Exp Med 207: 1843-1851.
109. Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M et al (2006). A brain-specific microRNA regulates dendritic spine development. Nature 439: 283-289.
110. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S et al (2004). The CREB coactivator TORC2 functions as a calcium-and cAMP-sensitive coincidence detector. Cell 119: 61-74.
111. Self DW, Genova LM, Hope BT, Barnhart WJ, Spencer JJ, Nestler EJ (1998). Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J Neurosci 18: 1848-1859.
112. Shaywitz AJ, Greenberg ME (1999). CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68: 821-861.
113. Siegel RK (1984). Changing patterns of cocaine use: longitudinal observations, consequences, and treatment. NIDA Res Monogr 50: 92-110.
114. Stipanovich A, Valjent E, Matamales M, Nishi A, Ahn J-H, Maroteaux M et al (2008). A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 453: 879-884.
115. Substance Abuse and Mental Health Services Administration (SAaMHSA) (2010). The NSDUH Report: National Findings. SAaMHSA: Rockville, MD.
116. Suto N, Ecke L, Wise R (2009). Control of within-binge cocaine-seeking by dopamine and glutamate in the core of nucleus accumbens. Psychopharmacology 205: 431-439.
117. Suto N, Wise RA (2011). Satiating effects of cocaine are controlled by dopamine actions in the nucleus accumbens core. J Neurosci 31: 17917-17922.
118. Tornatzky W, Miczek KA (2000). Cocaine self-administration 'binges': transition from behavioral and autonomic regulation toward homeostatic dysregulation in rats. Psychopharmacology 148: 289-298.
119. Tsang J, Zhu J, van Oudenaarden A (2007). MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol Cell 26: 753-767.
120. Valjent E, Corvol J-C, Pagès C, Besson M-J, Maldonado R, Caboche J (2000). Involvement of the extracellular signal-regulated kinase cascade for cocainerewarding properties. J Neurosci 20: 8701-8709.
121. Valjent E, Pascoli V, Svenningsson P, Paul S, Enslen H, Corvol J-C et al (2005). Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc Natl Acad Sci USA 102: 491-496.
122. Van Esch H, Bauters M, Ignatius J, Jansen M, Raynaud M, Hollanders K et al (2005). Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males. Am J Hum Genet 77: 442-453.
123. Vanderschuren LJMJ, Di Ciano P, Everitt BJ (2005). Involvement of the dorsal striatum in cue-controlled cocaine seeking. J Neurosci 25: 8665-8670.
124. Veeneman MMJ, Broekhoven MH, Damsteegt R, Vanderschuren LJMJ (2012). Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine. Neuropsychopharmacology 37: 487-498.
125. Vo N, Klein ME, Varlamova O, Keller DM, Yamamoto T, Goodman RH et al (2005). A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci USA 102: 16426-16431.
126. Wayman GA, Davare M, Ando H, Fortin D, Varlamova O, Cheng HY et al (2008). An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci USA 105: 9093-9098.
127. Wee S, Specio SE, Koob GF (2007). Effects of dose and session duration on cocaine self-administration in rats. J Pharmacol Exp Therap 320: 1134-1143.
128. Weeks J (1962). Experimental morphine addiction: methods for automated intravenous injections in unrestrained rats. Science 138: 143-144.
129. Wikler A (1952). A psychodynamic study of a patient during experimental selfregulated re-addiction to morphine. Psychiatr Q 26: 270-293.
130. Wilson MC, Schuster CR (1972). The effects of chlorpromazine on psychomotor stimulant self-administration in the rhesus monkey. Psychopharmacologia 26: 115-126.
131. Yin HY, Knowlton BJ, Balleine BW (2004). Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning. Eur J Neurosci 19: 181-189.
132. Yokel RA, Pickens R (1974) Drug level of d-and /-amphetamine during intravenous self-administration. Psychopharmacology 34: 255-264.
133. Zachariou V, Benoit-Marand M, Allen PB, Ingrassia P, Fienberg AA, Gonon F et al (2002) Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1. Biol Psychiatry 51: 612-620.
134. Zachariou V, Sgambato-Faure V, Sasaki T, Svenningsson P, Berton O, Fienberg AA et al (2005). Phosphorylation of DARPP-32 at threonine-34 is required for cocaine action. Neuropsychopharmacology 31: 555-562.
135. Zapata A, Minney VL, Shippenberg TS (2010). Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats. J Neurosci 30: 15457-15463.
136. Zhou Y, Wu H, Li S, Chen Q, Cheng XW, Zheng J et al (2006). Requirement of TORC1 for late-phase long-term potentiation in the hippocampus. PLoS One 1: e16.